Vancomycin-Resistant<i>Enterococcus faecium</i>in Tunisia: Emergence of Novel Clones

Dziri, Raoudha; Kara, Feriel El; Barguellil, Farouk; Ouzari, Hadda-Imen; Asli, Mohamed Selim El; Klibi, Naouel

doi:10.1089/mdr.2018.0158

Cited by 9 publications

(14 citation statements)

References 34 publications

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“…ST16, ST17, ST203, and ST65 types were reported as associated with CC17 in linezolid resistant E faecium strains in a study conducted in Greece 35 . Two new sequence types assigned to ST1463 and ST1464 were reported from Tunisia 36 . In this study, strains with linezolid resistance were found to be associated with ST203, ST78, and ST17 types, but as can be seen from the results, there is no homogeneous group to be associated with linezolid resistance.…”

Section: Discussioncontrasting

confidence: 49%

“…and ST1464 were reported from Tunisia. 36 In this study, strains with linezolid resistance were found to be associated with ST203, ST78, and ST17 types, but as can be seen from the results, there is no homogeneous group to be associated with linezolid resistance. The investigation of the worldwide prevalence of the types detected in our study showed that ST78 was reported in Italy, Austria, Germany, Korea, Hungary, Holland, China, Japan, Lithuania, and Portugal;…”

Section: Discussionmentioning

confidence: 54%

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Clonal distribution of vancomycin‐resistant Enterococcus faecium in Turkey and the new singleton ST733

Erdem

Kayacan

Öncül

et al. 2020

Clinical Laboratory Analysis

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Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 54%

Clonal distribution of vancomycin‐resistant Enterococcus faecium in Turkey and the new singleton ST733

Erdem

Kayacan

Öncül

et al. 2020

Clinical Laboratory Analysis

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“…Antibacterial‐resistant Enterococcus was found in feces of pets and camels, wild birds, irrigation water from farm environments, food vegetables, hospital environments, animal meat, and patients in Tunisia . Resistance to VAN, macrolides, aminoglycosides, β‐lactams, and TET was detected in the environment, animals and humans, with the majority of the isolates being E. faecium , followed by E. faecalis .…”

Section: Resultsmentioning

confidence: 99%

Molecular epidemiology and mechanisms of antibiotic resistance inEnterococcusspp.,Staphylococcusspp., andStreptococcusspp. in Africa: a systematic review from a One Health perspective

Sekyere

Mensah

2019

Annals of the New York Academy of Sciences

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A systematic review of antibiotic‐resistant Gram‐positive bacteria in Africa from a One Health perspective is lacking. Here, we report result from a search for English‐language articles on the resistance mechanisms and clonality of Gram‐positive bacteria in Africa between 2007 and 2019 reported in PubMed, Web of Science, ScienceDirect, and African Journals OnLine; 172 studies from 22 different African countries were identified. Resistance genes, such as mecA, erm(B), erm(C), tet(M), tet(K), tet(L), vanB, vanA, vanC, and tet(O), were found to be common. Staphylococcus spp., Enterococcus spp., and Streptococcus spp. were the main species reported by the studies, with clones such as Staphylococcus aureus ST5 (n = 218 isolates), ST8 (n = 127 isolates), ST80 (n = 133 isolates), and ST88 (n = 117 isolates), and mobile genetic elements such as IS16 (n = 28 isolates), IS256 (n = 96), Tn916 (n = 107 isolates), and SCCmec (n = 4437 isolates) identified. SCCmec IV (n = 747 isolates) was predominant, followed by SCCmec III (n = 305 isolates), SCCmec II (n = 163 isolates), SCCmec V (n = 135 isolates), and SCCmec I (n = 79 isolates). Resistance to penicillin (n = 5926 isolates), tetracycline (n = 5300 isolates), erythromycin (n = 5151 isolates), rifampicin (n = 3823 isolates), gentamycin (n = 3494 isolates), sulfamethoxazole/trimethoprim (n = 3089 isolates), and ciprofloxacin (n = 2746 isolates) was common in most reports from 22 countries. Clonal dissemination of resistance across countries and between humans, animals, and the environment was observed. Resistance rates ranged from 1.4% to 100% for 15 of the studies; 10 were One Health–related studies. Strict infection control measures, antimicrobial stewardship, and periodic One Health epidemiological surveillance studies are needed to monitor and contain the threat of increasing antibiotic resistance in Africa.

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“…The four VREfm strains from several regions (Algiers, Tipaza, Constantine and Oran) belonged to ST80, suggesting the spread of this subgroup in Algerian hospitals. The ST80, previousely reported in some European countries (including Germany and Danemark) [34,35] and in Tunisia [27,28] was also reported in 2012 among vancomycin-susceptible E. faecium strains from Annaba hospital [24] and recently in 2018 among three VREfm isolated in Batna hospital [20].…”

Section: Multilocus Sequence Typingmentioning

confidence: 98%

“…In addition to their natural resistance to cephalosporins and low concentrations of aminoglycosides, the ability of enterococci to acquire resistance to other antibiotics is recognized, which is often supported by the same mobile genetic element harboring multiple resistance genes [2,4,13]. The multidrug-resistance of VREfm strains is prevalent as reported in several parts of the world [2-4, 7-10, 13] and recently in North Africa (including Tunisia and Egypt) [26][27][28][29].…”

Section: Antimicrobial Susceptibility and Genotyping Of Vancomycin-rementioning

confidence: 99%

Vancomycin-resistant Enterococcus faecium in Algeria: phenotypic and genotypic characterization of clinical isolates

Benamrouche

Guettou

Henniche³

et al. 2021

J Infect Dev Ctries

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Introduction: vancomycin-resistant Enterococcus faecium (VREfm) is a major public health problem worldwide. The aim of our study was to determine the microbiological, epidemiological and molecular characteristics of VREfm isolated in north-central, eastern and western Algeria. Methodology: a collection of 48 VREfm isolated from September 2010 to April 2017 in several Algerian hospitals were studied. Minimum inhibitory concentrations (MICs) were determined by E-test method according to CLSI guidelines. the detection of van genotype of all strains was performed by PCR. Clonal relationship of five VREfm targeted by region were characterized using multilocus sequence typing (MLST). Results: All isolates have multidrug-resistance (MDR) and were resistant to at least five classes of antibiotics; however, all were susceptible to tigecycline and daptomycin with MIC50 at 0.094 µg/mL and 2 µg/mL respectively. All strains belonged to vanA genotype and have high level of resistance to vancomycin and teicoplanin. MLST revealed two sequence types (STs): ST80 (from the four regions of Algeria) and ST789, both belonging to the former hospital-adapted clonal complex CC17. Conclusions: the alarming dissemination of MDR E. faecium vanA and the ST80 in several regions of Algeria suggest a clonal spread of VREfm strains, which urgently require implementation of adequate infection control measures.

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Vancomycin-ResistantEnterococcus faeciumin Tunisia: Emergence of Novel Clones

Cited by 9 publications

References 34 publications

Clonal distribution of vancomycin‐resistant Enterococcus faecium in Turkey and the new singleton ST733

Clonal distribution of vancomycin‐resistant Enterococcus faecium in Turkey and the new singleton ST733

Molecular epidemiology and mechanisms of antibiotic resistance inEnterococcusspp.,Staphylococcusspp., andStreptococcusspp. in Africa: a systematic review from a One Health perspective

Vancomycin-resistant Enterococcus faecium in Algeria: phenotypic and genotypic characterization of clinical isolates

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