Vancomycin-loaded chitosan aerogel particles for chronic wound applications

López‐Iglesias, Clara; Barros, Joana; Ardao, Inés; Monteiro, Fernando J.; Álvarez-Lorenzo, Carmen; Gómez-Amoza, J.L.; García‐González, Carlos A.

doi:10.1016/j.carbpol.2018.10.012

Cited by 147 publications

(117 citation statements)

References 49 publications

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“…Porosity and bulk density values were consistent with previous reports on chitosan aerogels gelified using a similar precipitation method, but the specific surface area was slightly lower [36,37], The aerogels obtained from chitosan gels processed by jet cutting with a nozzle diameter of 500 μm and a cutting disc velocity of 4000 rpm were lightweight (bulk = 0.060 ± 0.002 g/cm 3 ) and highly porous (ε = 95.6% ± 0.2%), and presented excellent textural properties (aBET = 188.0 ± 9.4 m 2 /g). Porosity and bulk density values were consistent with previous reports on chitosan aerogels gelified using a similar precipitation method, but the specific surface area was slightly lower [36,37], The aerogels obtained from chitosan gels processed by jet cutting with a nozzle diameter of 500 µm and a cutting disc velocity of 4000 rpm were lightweight (ρ bulk = 0.060 ± 0.002 g/cm 3 ) and highly porous (ε = 95.6% ± 0.2%), and presented excellent textural properties (a BET = 188.0 ± 9.4 m 2 /g). Porosity and bulk density values were consistent with previous reports on chitosan aerogels gelified using a similar precipitation method, but the specific surface area was slightly lower [36,37], probably due to a higher degree of shrinkage of the gel during gelation in ethanol medium [38].…”

Section: Jet Cutting Of Chitosan Gels and Morphology And Textural Prosupporting

confidence: 90%

“…Porosity and bulk density values were consistent with previous reports on chitosan aerogels gelified using a similar precipitation method, but the specific surface area was slightly lower [36,37], The aerogels obtained from chitosan gels processed by jet cutting with a nozzle diameter of 500 µm and a cutting disc velocity of 4000 rpm were lightweight (ρ bulk = 0.060 ± 0.002 g/cm 3 ) and highly porous (ε = 95.6% ± 0.2%), and presented excellent textural properties (a BET = 188.0 ± 9.4 m 2 /g). Porosity and bulk density values were consistent with previous reports on chitosan aerogels gelified using a similar precipitation method, but the specific surface area was slightly lower [36,37], probably due to a higher degree of shrinkage of the gel during gelation in ethanol medium [38]. Chitosan aerogels with higher specific surface areas have also been described, but involved the use of chemical crosslinkers that could leave toxic residues in the gels, raising regulatory concerns [39].…”

Section: Jet Cutting Of Chitosan Gels and Morphology And Textural Prosupporting

confidence: 90%

“…The obtained drug loss can be explained by drainage of the water containing the drug from the chitosan solution when dropped in the ethanol of the gelation bath. In any case, the loading was still high if compared to other drug-loaded aerogel formulations prepared in aqueous medium (≈ 12%) [36].…”

Section: Drug Loading and Releasementioning

confidence: 74%

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Jet Cutting Technique for the Production of Chitosan Aerogel Microparticles Loaded with Vancomycin

et al. 2020

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Biopolymer-based aerogels can be obtained by supercritical drying of wet gels and endowed with outstanding properties for biomedical applications. Namely, polysaccharide-based aerogels in the form of microparticles are of special interest for wound treatment and can also be loaded with bioactive agents to improve the healing process. However, the production of the precursor gel may be limited by the viscosity of the polysaccharide initial solution. The jet cutting technique is regarded as a suitable processing technique to overcome this problem. In this work, the technological combination of jet cutting and supercritical drying of gels was assessed to produce chitosan aerogel microparticles loaded with vancomycin HCl (antimicrobial agent) for wound healing purposes. The resulting aerogel formulation was evaluated in terms of morphology, textural properties, drug loading, and release profile. Aerogels were also tested for wound application in terms of exudate sorption capacity, antimicrobial activity, hemocompatibility, and cytocompatibility. Overall, the microparticles had excellent textural properties, absorbed high amounts of exudate, and controlled the release of vancomycin HCl, providing sustained antimicrobial activity.

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Section: Jet Cutting Of Chitosan Gels and Morphology And Textural Prosupporting

confidence: 90%

“…Porosity and bulk density values were consistent with previous reports on chitosan aerogels gelified using a similar precipitation method, but the specific surface area was slightly lower [36,37], The aerogels obtained from chitosan gels processed by jet cutting with a nozzle diameter of 500 µm and a cutting disc velocity of 4000 rpm were lightweight (ρ bulk = 0.060 ± 0.002 g/cm 3 ) and highly porous (ε = 95.6% ± 0.2%), and presented excellent textural properties (a BET = 188.0 ± 9.4 m 2 /g). Porosity and bulk density values were consistent with previous reports on chitosan aerogels gelified using a similar precipitation method, but the specific surface area was slightly lower [36,37], probably due to a higher degree of shrinkage of the gel during gelation in ethanol medium [38]. Chitosan aerogels with higher specific surface areas have also been described, but involved the use of chemical crosslinkers that could leave toxic residues in the gels, raising regulatory concerns [39].…”

Section: Jet Cutting Of Chitosan Gels and Morphology And Textural Prosupporting

confidence: 90%

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Jet Cutting Technique for the Production of Chitosan Aerogel Microparticles Loaded with Vancomycin

et al. 2020

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“…To address this problem, we considered chitosan (CS) which is a biobased material derived from sustainable resources. CS is obtained by deacetylation of chitin and its physicochemical properties are determined by the degree of deacetylation and molecular weight . It was identified as a good start material for fabricating aerogels with unique advantages, such as good flexibility, nontoxicity, cost‐effectiveness and biodegradability.…”

Section: Compressive Properties and Shape Memory Performance Of The Cmentioning

confidence: 99%

Fabrication of Shape‐Memory Aerogel Based on Chitosan/Poly(ethylene glycol) Diacrylate Semi‐Interpenetrating Networks via a Facile and Eco‐Friendly Strategy

Xiao

et al. 2019

Macro Materials & Eng

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exhibit strong advantages in providing diverse mechanical properties, such as varying from stiff to high elasticity to enable adaption to a wide range of demands.While the application of aerogels in smart materials has attracted increasing attention, ensuring full functionality in a porous structure is still highly challenging. As one of the booming smart materials, shape-memory polymers (SMPs) have been intensively investigated, and numerous multiresponsive, [20][21][22][23][24][25] multifunctional shape memory polymeric bulk materials [26][27][28][29] or hydrogels [30][31][32][33][34][35] have been developed. However, to the best of our knowledge, there have been very few reports about shape memory aerogels. [36,37] Rowan and coworkers [38] developed a thermal responsive shape memory aerogel from a thiol-ene network with a glass temperature above room temperature, and showed that it displays very good shape memory performance. However, this shape memory aerogel is produced from an organogel. Generally, fabricating aerogels from hydrogels is a more economical and eco-friendly strategy.Herein, we seek to develop a shape memory polymeric aerogel (SMPA) from the corresponding hydrogel via an eco-friendly strategy by choosing water soluble and highly matchable constituent materials. It is well-known that crystalline poly(ethylene glycol) (PEG) with a melting temperature (T m ) above room temperature is a favorable component for the development of thermally induced SMPs, and its water solubility makes it a good candidate for SMPA. However, the aerogel formed from a single highly crystalline PEG component will show a poor mechanical performance. To address this problem, we considered chitosan (CS) which is a biobased material derived from sustainable resources. CS is obtained by deacetylation of chitin and its physicochemical properties are determined by the degree of deacetylation and molecular weight. [39] It was identified as a good start material for fabricating aerogels with unique advantages, such as good flexibility, nontoxicity, cost-effectiveness and biodegradability. Thus, CS was chosen as the other precursor material to enhance the aerogel skeleton. In this work, we prepared a shape memory aerogel based on chitosan/poly(ethylene glycol) diacrylate (CS/PEGDA) semi-interpenetrating networks (semi-IPNs) via a facile one-pot photocrosslinking approach. The feed ratio of CS and diacrylic PEG (PEGDA) precursors with different molecular weights were tuned to Shape-Memory Aerogels While the field of shape memory polymers (SMPs) has developed rapidly, it is still highly challenging to obtain SMPs in the form of aerogels (SMPAs) due to the unique technique used for the fabrication of the aerogels and their high porosity. Herein, a thermally induced SMPA based on chitosan/poly(ethylene glycol) diacrylate (CS/PEGDA) semi-interpenetrating networks is reported that are produced using an eco-friendly strategy. The main network is responsible for the shape memory effect (SME) and can be easily tuned by varying the feed rat...

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“…Vancomycin, for instance, is an actinobacteria-derived glycopeptide antibiotic that inhibits the proper cell wall synthesis in Grampositive bacteria and is used to treat several infections, including skin infections. It was discovered in the 1950's but was soon discarded in favor of other antibiotics deemed more efficient, particularly against bacteria from enterococci and staphylococci strains [9,10]. However, recent studies have rekindled the interest on this antibiotic by studying new ways to administer the antibiotic that will reduce bacteria resistance [10,11].…”

Section: Introductionmentioning

confidence: 99%

New method to produce poly(vinyl alcohol)/cellulose acetate films with improved antibacterial action

Felgueiras

Teixeira

Tavares

et al. 2020

Materials Today: Proceedings

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New alternatives to the conventional wound dressings are being engineered. Here, we propose the processing of two biodegradable polymers, poly(vinyl alcohol) (PVA) and cellulose acetate (CA), in the form of films via a new method that combines principles of solvent casting and phase-inversion. Highly flexible and mechanically resistant films were obtained. PVA/CA films were then treated with the antibiotic vancomycin via two methods, blending and physisorption (via dopamine). Immobilization of vancomycin was proven efficient in promoting the films' antibacterial action against Staphylococcus epidermidis bacteria. Data demonstrates the potentialities of PVA/CA films for prospective wound healing applications.

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Vancomycin-loaded chitosan aerogel particles for chronic wound applications

Cited by 147 publications

References 49 publications

Jet Cutting Technique for the Production of Chitosan Aerogel Microparticles Loaded with Vancomycin

Jet Cutting Technique for the Production of Chitosan Aerogel Microparticles Loaded with Vancomycin

Fabrication of Shape‐Memory Aerogel Based on Chitosan/Poly(ethylene glycol) Diacrylate Semi‐Interpenetrating Networks via a Facile and Eco‐Friendly Strategy

New method to produce poly(vinyl alcohol)/cellulose acetate films with improved antibacterial action

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