New method to produce poly(vinyl alcohol)/cellulose acetate films with improved antibacterial action

Felgueiras, Helena P.; Teixeira, Marta A.; Tavares, Tânia D.; Amorim, M. T. Pessoa de

doi:10.1016/j.matpr.2019.12.100

Cited by 15 publications

(13 citation statements)

References 18 publications

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“…Therefore, vancomycin was reported as weak against the Gram-negative bacteria but strong against the Gram-positive bacteria. As such, the absence of the outer membrane and periplasm in the Gram-positive bacteria allows a higher permeability of vancomycin through its cellular wall, which possess a hydrophilic porous structure [43][44][45].…”

Section: Agar-well Diffusionmentioning

confidence: 99%

“…The same explanation can be applied to the Gram-negative bacteria. The large size of this glycopeptide precludes it from being capable of penetrating the outer membrane of Gram-negative bacteria and inducing morphology changes and autolysin-triggered cell rupture, as happens in Gram-positive bacteria [43][44][45]. We postulate that because of the superior concentration of vancomycin (1000 µg/mL) required to kill these bacteria and its fast action, these molecules accumulate along the surface of the bacterium, isolating it from the media and respective nutrients, and providing enough steric hindrance to prevent peptidoglycan synthesis.…”

Section: Cell-wall Disruption: Mechanisms Of Actionmentioning

confidence: 99%

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Activity of Specialized Biomolecules against Gram-Positive and Gram-Negative Bacteria

et al. 2020

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The increased resistance of bacteria against conventional pharmaceutical solutions, the antibiotics, has raised serious health concerns. This has stimulated interest in the development of bio-based therapeutics with limited resistance, namely, essential oils (EOs) or antimicrobial peptides (AMPs). This study envisaged the evaluation of the antimicrobial efficacy of selected biomolecules, namely LL37, pexiganan, tea tree oil (TTO), cinnamon leaf oil (CLO) and niaouli oil (NO), against four bacteria commonly associated to nosocomial infections: Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa. The antibiotic vancomycin and silver nanoparticles (AgNPs) were used as control compounds for comparison purposes. The biomolecules were initially screened for their antibacterial efficacy using the agar-diffusion test, followed by the determination of minimal inhibitory concentrations (MICs), kill-time kinetics and the evaluation of the cell morphology upon 24 h exposure. All agents were effective against the selected bacteria. Interestingly, the AgNPs required a higher concentration (4000–1250 μg/mL) to induce the same effects as the AMPs (500–7.8 μg/mL) or EOs (365.2–19.7 μg/mL). Pexiganan and CLO were the most effective biomolecules, requiring lower concentrations to kill both Gram-positive and Gram-negative bacteria (62.5–7.8 μg/mL and 39.3–19.7 μg/mL, respectively), within a short period of time (averaging 2 h 15 min for all bacteria). Most biomolecules apparently disrupted the bacteria membrane stability due to the observed cell morphology deformation and by effecting on the intracellular space. AMPs were observed to induce morphological deformations and cellular content release, while EOs were seen to split and completely envelope bacteria. Data unraveled more of the potential of these new biomolecules as replacements for the conventional antibiotics and allowed us to take a step forward in the understanding of their mechanisms of action against infection-related bacteria.

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Section: Agar-well Diffusionmentioning

confidence: 99%

Section: Cell-wall Disruption: Mechanisms Of Actionmentioning

confidence: 99%

Activity of Specialized Biomolecules against Gram-Positive and Gram-Negative Bacteria

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“…The addition of 20 wt. % CA in the PVA matrix improved the porosity of the films, and the antibacterial activity of the composite was observed with the incorporation of vancomycin, which can be applied in wound healing applications [ 86 ].…”

Section: Cellulose-based Polymers In 3d Printing Technologymentioning

confidence: 99%

Extending Cellulose-Based Polymers Application in Additive Manufacturing Technology: A Review of Recent Approaches

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The materials for additive manufacturing (AM) technology have grown substantially over the last few years to fulfill industrial needs. Despite that, the use of bio-based composites for improved mechanical properties and biodegradation is still not fully explored. This limits the universal expansion of AM-fabricated products due to the incompatibility of the products made from petroleum-derived resources. The development of naturally-derived polymers for AM materials is promising with the increasing number of studies in recent years owing to their biodegradation and biocompatibility. Cellulose is the most abundant biopolymer that possesses many favorable properties to be incorporated into AM materials, which have been continuously focused on in recent years. This critical review discusses the development of AM technologies and materials, cellulose-based polymers, cellulose-based three-dimensional (3D) printing filaments, liquid deposition modeling of cellulose, and four-dimensional (4D) printing of cellulose-based materials. Cellulose-based AM material applications and the limitations with future developments are also reviewed.

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“…CA is a polymer that is easily soluble in common organic solvents, such as acetone, acetic acid, N,N-dimethylacetamide, and their mixtures, low-cost derivative of cellulose with excellent biocompatibility, high water adsorption capacities, good mechanical stability, non-toxicity, and can be efficiently processed into membranes, films, and fibers from either solutions or melts [21,[24][25][26][27][28]. Electrospinning allows for the production of CA-based nanomeshes with an intricate and complex architecture that can be functionalized with active biomolecules to address the specific demands of acute and chronic wounds via simple, reproducible and cost effective approaches [29][30][31]. The nanocellulose is another cellulose based material that has gathered much interest in the last few decades, for prospective biomedical field.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing

et al. 2020

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Wound healing requires careful, directed, and effective therapies to prevent infections and accelerate tissue regeneration. In light of these demands, active biomolecules with antibacterial properties and/or healing capacities have been functionalized onto nanostructured polymeric dressings and their synergistic effect examined. In this work, various antibiotics, nanoparticles, and natural extract-derived products that were used in association with electrospun nanocomposites containing cellulose, cellulose acetate and different types of nanocellulose (cellulose nanocrystals, cellulose nanofibrils, and bacterial cellulose) have been reviewed. Renewable, natural-origin compounds are gaining more relevance each day as potential alternatives to synthetic materials, since the former undesirable footprints in biomedicine, the environment, and the ecosystems are reaching concerning levels. Therefore, cellulose and its derivatives have been the object of numerous biomedical studies, in which their biocompatibility, biodegradability, and, most importantly, sustainability and abundance, have been determinant. A complete overview of the recently produced cellulose-containing nanofibrous meshes for wound healing applications was provided. Moreover, the current challenges that are faced by cellulose acetate- and nanocellulose-containing wound dressing formulations, processed by electrospinning, were also enumerated.

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New method to produce poly(vinyl alcohol)/cellulose acetate films with improved antibacterial action

Cited by 15 publications

References 18 publications

Activity of Specialized Biomolecules against Gram-Positive and Gram-Negative Bacteria

Activity of Specialized Biomolecules against Gram-Positive and Gram-Negative Bacteria

Extending Cellulose-Based Polymers Application in Additive Manufacturing Technology: A Review of Recent Approaches

Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing

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