Vancomycin incorporated chitosan/gelatin coatings coupled with TiO2–SrHAP surface modified cp-titanium for osteomyelitis treatment

Nancy, D; Rajendran, N.

doi:10.1016/j.ijbiomac.2018.01.004

Cited by 33 publications

(4 citation statements)

References 40 publications

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“…6 . Emergency conditions, such as the sudden onset of inflammation, osteomyelitis, and unexpected viral attack, may arise with an imminent requirement for high concentrations of drugs [ 210 ]. Such critical situations can be addressed by employing stimuli-responsive drug delivery systems triggered by external conditions, such as magnetic, pH, radiofrequency (RF), temperature, ultrasound, ultraviolet (UV) light, or voltage-sensitive drug delivery systems.…”

Section: Potential Of Titanium Alloys For Regenerative Medicine and Nanomedicinementioning

confidence: 99%

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

et al. 2021

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Commercially pure titanium and titanium alloys have been among the most commonly used materials for biomedical applications since the 1950s. Due to the excellent mechanical tribological properties, corrosion resistance, biocompatibility, and antibacterial properties of titanium, it is getting much attention as a biomaterial for implants. Furthermore, titanium promotes osseointegration without any additional adhesives by physically bonding with the living bone at the implant site. These properties are crucial for producing high-strength metallic alloys for biomedical applications. Titanium alloys are manufactured into the three types of α, β, and α + β. The scientific and clinical understanding of titanium and its potential applications, especially in the biomedical field, are still in the early stages. This review aims to establish a credible platform for the current and future roles of titanium in biomedicine. We first explore the developmental history of titanium. Then, we review the recent advancement of the utility of titanium in diverse biomedical areas, its functional properties, mechanisms of biocompatibility, host tissue responses, and various relevant antimicrobial strategies. Future research will be directed toward advanced manufacturing technologies, such as powder-based additive manufacturing, electron beam melting and laser melting deposition, as well as analyzing the effects of alloying elements on the biocompatibility, corrosion resistance, and mechanical properties of titanium. Moreover, the role of titania nanotubes in regenerative medicine and nanomedicine applications, such as localized drug delivery system, immunomodulatory agents, antibacterial agents, and hemocompatibility, is investigated, and the paper concludes with the future outlook of titanium alloys as biomaterials. Graphic abstract

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Section: Potential Of Titanium Alloys For Regenerative Medicine and Nanomedicinementioning

confidence: 99%

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

et al. 2021

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“…Nancy et al reported that their pure titanium was electrophoretically modified using double-layer coatings consisting of TiO 2 -SrHAP as the first layer followed by vancomycin-incorporated chitosan/gelatin as the second layer; the two layers are attracted to one another through electrostatic force, and each layer has functional groups with different properties, achieving a composite performance. As Nancy et al concluded, one layer is used as a storage space for vancomycin, and the other layer is a “switch” that controls the release of drugs; a schematic representation of the step-by-step process involved in fabricating single- or double-layer coatings is shown in Figure 3 F [ 58 ]. This technique was similarly used in the reports of Ionita et al [ 65 ] and Zarghami et al [ 66 ].…”

Section: Antibacterial Effectsmentioning

confidence: 99%

“… ( A ) Experimental scheme of Zhang et al; reprinted with permission from [ 29 ]; copyright 2020 The Royal Society of Chemistry. ( B ) Intuitive structure of the designed material; reprinted with permission from [ 50 ]; copyright 2015 Martin B. Bezuidenhout et al ( C ) Top-view and cross-sectional SEM images of the material; reprinted with permission from [ 30 ]; copyright 2014 Elsevier B.V. ( D ) Representative topographical AFM images of chitosan and a drug-eluting composite coating; reprinted with permission from [ 30 ]; copyright 2014 Elsevier B.V. ( E ) Drug release curve of experimental and control groups; reprinted with permission from [ 30 ]; copyright 2014 Elsevier B.V. ( F ) Experimental scheme of Nancy et al; reprinted with permission from [ 58 ]; copyright 2018 Elsevier B.V. …”

Section: Figurementioning

confidence: 99%

Titanium Implants and Local Drug Delivery Systems Become Mutual Promoters in Orthopedic Clinics

Gao

Zhao

et al. 2021

Nanomaterials

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Titanium implants have always been regarded as one of the gold standard treatments for orthopedic applications, but they still face challenges such as pain, bacterial infections, insufficient osseointegration, immune rejection, and difficulty in personalizing treatment in the clinic. These challenges may lead to the patients having to undergo a painful second operation, along with increased economic burden, but the use of drugs is actively solving these problems. The use of systemic drug delivery systems through oral, intravenous, and intramuscular injection of various drugs with different pharmacological properties has effectively reduced the levels of inflammation, lowered the risk of endophytic bacterial infection, and regulated the progress of bone tumor cells, processing and regulating the balance of bone metabolism around the titanium implants. However, due to the limitations of systemic drug delivery systems—such as pharmacokinetics, and the characteristics of bone tissue in the event of different forms of trauma or disease—sometimes the expected effect cannot be achieved. Meanwhile, titanium implants loaded with drugs for local administration have gradually attracted the attention of many researchers. This article reviews the latest developments in local drug delivery systems in recent years, detailing how various types of drugs cooperate with titanium implants to enhance antibacterial, antitumor, and osseointegration effects. Additionally, we summarize the improved technology of titanium implants for drug loading and the control of drug release, along with molecular mechanisms of bone regeneration and vascularization. Finally, we lay out some future prospects in this field.

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“…Chitosan (CS) is a natural polysaccharide, used widely in biomedical implants, scaffolds, drug delivery systems, biosensors and other biomedical applications nowadays (Archana, Dutta, & Dutta, 2013;Boccaccini, Keim, Ma, Li, & Zhitomirsky, 2010;D & N, 2018;D'Almeida et al, 2017;Li et al, 2019;Tian et al, 2016). Its immense significance in biomedical applications is because of the biocompatibility, acceptable hemocompatibility, antibacterial properties, positive host response and sufficient mechanical strength (F Pishbin, Simchi, Ryan, & Boccaccini, 2011;Puppi, Chiellini, Piras, & Chiellini, 2010;Sadasivuni et al, 2020;Sencadas et al, 2012;Sutha, Kavitha, Karunakaran, & Rajendran, 2013).…”

Section: Introductionmentioning

confidence: 99%

Surface functionalization of chitosan as a coating material for orthopaedic applications: A comprehensive review

Kumari

Tiyyagura

Pottathara

et al. 2021

Carbohydrate Polymers

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Vancomycin incorporated chitosan/gelatin coatings coupled with TiO2–SrHAP surface modified cp-titanium for osteomyelitis treatment

Cited by 33 publications

References 40 publications

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

Titanium Implants and Local Drug Delivery Systems Become Mutual Promoters in Orthopedic Clinics

Surface functionalization of chitosan as a coating material for orthopaedic applications: A comprehensive review

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