Surface functionalization of chitosan as a coating material for orthopaedic applications: A comprehensive review

Kumari, Suman; Tiyyagura, Hanuma Reddy; Pottathara, Yasir Beeran; Sadasivuni, Kishor Kumar; Ponnamma, Deepalekshmi; Douglas, Timothy E.L.; Skirtach, André G.; Mohan, M.

doi:10.1016/j.carbpol.2020.117487

Cited by 69 publications

(28 citation statements)

References 156 publications

(126 reference statements)

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“…In future work, the developed here nanofibrillar structures can be functionalized by different essential functional components, for example, pectins, [ 88,89 ] chitosan, [ 90 ] gentamicin, [ 91 ] which can be used to regulate environment and antibacterial properties. [ 92,93 ] Alternatively, nanoparticle functionalization of the surfaces would enable remote release capabilities, [ 94 ] while functionalization with anisotropic structure would permit mechanical properties control.…”

Section: Resultsmentioning

confidence: 99%

Nanofibrillar Hydrogels by Temperature Driven Self‐Assembly: New Structures for Cell Growth and Their Biological and Medical Implications

Abalymov

Santos

Meeren

et al. 2021

Adv Materials Inter

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Nanofibrillar structures are of importance in biomedicine, including lung, cardiovascular, liver, skin, neuroscience research, and tissue engineering. Developing advanced materials and interfaces should contribute to uncovering the mechanisms of diseases aiming to find cure. The similarity between the extracellular matrix (ECM) of soft tissue and hydrogels, characterized by a high water‐content viscoelastic polymeric fiber, has stimulated the development of hydrogels for biomedical applications. However, most hydrogels have a meshy structure resulting in poor cell adhesion properties. Here, fabrication of gellan gum (GG) hydrogels arranged by thermally driven self‐assembly into a network of nanofibers is reported. Mechanical properties of such nanofibrillar hydrogels are analyzed on micro‐ and macroscales. As a result, and in sharp contrast to commonly produced meshy GG hydrogels, the nanofiber‐based hydrogels facilitate the adherence and lead to proliferation of cells. This is assigned to microstructural rearrangements characterized by a changing density and pore size decrease, accompanied with a lower water content. Cell growth on such nanofibrillar structures is investigated for osteoblasts, which are chosen as a model system. The developed nanofibrous interfaces in this study are envisioned to be applicable for growing various types of cells and they should contribute to better understanding cell interactions with ECM.

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Section: Resultsmentioning

confidence: 99%

Nanofibrillar Hydrogels by Temperature Driven Self‐Assembly: New Structures for Cell Growth and Their Biological and Medical Implications

Abalymov

Santos

Meeren

et al. 2021

Adv Materials Inter

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“…A homogeneous liquid film is obtained and the subsequent solvent evaporation at room temperature (RT) results in the formation of the desired coating. To obtain films with specific thickness and properties, solution composition and concentration, solvent features (nature, polarity, solubility and volatility), immersion time, withdrawal speed and environmental humidity can be modified during the dip-coating process [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

et al. 2021

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To modulate the biofunctionality of implantable medical devices commonly used in clinical practice, their surface modification with bioactive polymeric coatings is an attractive and successful emerging strategy. Biodegradable coatings based on poly(lactic acid-co-glycolic acid), PLGA, represent versatile and safe candidates for surface modification of implantable biomaterials and devices, providing additional tunable ability for topical delivery of desired therapeutic agents. In the present study, Ibuprofen-loaded PLGA coatings (PLGA/IBUP) were obtained by using the dip-coating and drop-casting combined protocol. The composite materials demonstrated long-term drug release under biologically simulated dynamic conditions. Reversible swelling phenomena of polymeric coatings occurred in the first two weeks of testing, accompanied by the gradual matrix degradation and slow release of the therapeutic agent. Irreversible degradation of PLGA coatings occurred after one month, due to copolymer’s hydrolysis (evidenced by chemical and structural modifications). After 30 days of dynamic testing, the cumulative release of IBUP was ~250 µg/mL. Excellent cytocompatibility was revealed on human-derived macrophages, fibroblasts and keratinocytes. The results herein evidence the promising potential of PLGA/IBUP coatings to be used for surface modification of medical devices, such as metallic implants and wound dressings.

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“…110 Chitosan layers are stable, and depending on the concentration of chitosan, its molecular weight, the degree of deacetylation and application technique, they degrade at different rates, even allowing for long-term use. 111,112 Surface modification significantly influences the mechanical properties of the scaffolding. Three-dimensional, porous scaffolds made of polycaprolactam (PCL) were covered with layers of chitosan at various concentrations, from 1% to 3%.…”

Section: Chitosan As a Scaffold Surface Modifiermentioning

confidence: 99%

Biomimetic scaffolds based on chitosan in bone regeneration. A review.

Kołakowska

Gadomska‐Gajadhur

Ruśkowski³

2021

Preprint

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The article focuses on a polysaccharide of natural origin – chitosan and its application in tissue engineering. The preparation process and physicochemical properties of the saccharide are described. The degradation of chitosan and the properties influencing the process both outside and in living organism were examined. Four applications in bone tissue engineering can be distinguished: preparation of cell scaffolds exclusively from chitosan, from a chitosan composite or from a chitosan polyelectrolyte complex. The fourth way is to modify the surface of scaffolds made of other materials by covering them with a layer of chitosan. At the end of the article, the processes taking place after placing the implant inside the body are described, how the structure of chitosan affects the behaviour of bone cells in the adhesion process and life processes.

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Surface functionalization of chitosan as a coating material for orthopaedic applications: A comprehensive review

Cited by 69 publications

References 156 publications

Nanofibrillar Hydrogels by Temperature Driven Self‐Assembly: New Structures for Cell Growth and Their Biological and Medical Implications

Nanofibrillar Hydrogels by Temperature Driven Self‐Assembly: New Structures for Cell Growth and Their Biological and Medical Implications

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

Biomimetic scaffolds based on chitosan in bone regeneration. A review.

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