Vancomycin during pregnancy: Does it cause hearing loss or nephrotoxicity in the infant?

Urinary Tract Infection and Bacteriuria in Pregnancy

“…Its use is associated with potential nephrotoxicity and ototoxicity, 76 although these effects have not been demonstrated in the few published reports of vancomycin use in pregnancy. 44,77,78 Because of the very limited evidence of vancomycin use in pregnancy, it should be used with caution only when no alternatives exist.…”

Anti-infectives

“…With 1 g of the glycopeptide antibiotic, vancomycin, administered intravenously, 12.7 mg/L were measured in the milk (Reyes 1989). Mathematically, such a concentration represents 5.8% of the maternal dose for an exclusively breastfed infant.…”

Angeborene Herzfehler und erworbene Herzklappenfehler in der Schwangerschaft

“…Aminoglykosid-Antibiotika bergen das potentielle Risiko einer Schädigung des fetalen Nervus vestibulocochlearis [16], während für Vancomycin bei Standarddosierung und "drug monitoring" kein erhöhtes fetales Risiko anzunehmen ist [54]. Chinolone sind während der Schwangerschaft kontraindiziert [16].…”