Angeborene Herzfehler und erworbene Herzklappenfehler in der Schwangerschaft

Abstract

With respect to anticoagulation during pregnancy, there is an ongoing debate about the potential risk and benefit of phenprocoumon, standard heparins, and low molecular heparins. Withdrawal of any anticoagulation results in the most favorable fetal outcome, oral anticoagulation throughout pregnancy in the best prognosis for the mother. An individual approach by an experienced center taking all therapeutic options into account is probably the best strategy.

Electrically-Induced Ventricular Fibrillation Alters Cardiovascular Function and Expression of Apoptotic and Autophagic Proteins in Rat Hearts

“…The present investigation addresses this issue by examination of electrically-induced VF on cardiac function, magnitude of infarct zone extent, and expression of proteins that are clinical and/or objective laboratory biomarkers for normal, versus disrupted heart function, necrosis, apoptosis, and autophagy. It has previously been demonstrated that alterations in the principle cardiac functions, including aortic flow (AF), coronary flow (CF), cardiac output (CO), stroke volume (SV), and heart rate (HR) correlate with occurrence of arrhythmias in ways that clearly demonstrate common underlying regulatory processes for both cardiac functions and arrhythmogenesis [17,18,19]. Nevertheless, it is presently unknown whether various pathologic processes, which result in disruption of physiological heart function and contributing cellular processes, such as apoptosis and autophagy, may be promoted by the occurrence of arrhythmias.…”