Vanadium(V) Complexes with Bromo-Substituted Hydrazones: Synthesis, Characterization, X-ray Crystal Structures and Antimicrobial Activity

Abstract

Two new V V complexes with the bromo-substituted hydrazones N'-(3-bromo-2-hydroxybenzylidene)-3-hydroxy-4-methoxybenzohydrazide (H 2 L 1), N'-(3-bromo-2-hydroxybenzylidene)-3,5-dimethoxybenzohydrazide (H 2 L 2), [VOL 1 (OCH 3)(CH 3 OH)] (1) and [VOL 2 (OCH 3)(CH 3 OH)] (2), were synthesized and structurally characterized by IR, UV-Vis and 1 H NMR spectroscopy, as well as single-crystal X-ray determination. The V atom in the mononuclear complexes are six-coordinated in octahedral geometry. The free hydrazones and the complexes were studied on their antibacterial activity on S. aureus, B. subtilis, E. coli and P. fluorescence, and antifungal activity on C. albicans and A. niger. The bromo groups of the hydrazone ligands may increase their antibacterial activity.

Syntheses, Characterization, Crystal Structures and Antimicrobial Activity of Schiff Base Copper(II) Complexes Derived from 2-Bromo-6-((2-(isopropylamino) ethylimino)methyl)phenol

“…5 Recently, our research group has re-ported some Schiff base complexes with biological properties. 6 In pursuit of new Schiff base complexes with potential antimicrobial property, in this work, three new copper(II) complexes, [Cu(LH) 2 ]Br 2 (1), [Cu(LH) 2 ]NCS 2 (2), and [Cu(LH) 2 ](NO 3 ) 2 (3), where LH is the zwitterionic form of 2-bromo-6-((2-(isopropylamino)ethylimino) methyl)phenol (HL), and their antimicrobial activities are present.…”