Syntheses, Characterization, Crystal Structures and Antimicrobial Activity of Schiff Base Copper(II) Complexes Derived from 2-Bromo-6-((2-(isopropylamino) ethylimino)methyl)phenol

Abstract

Three new copper(II) complexes, [Cu(LH)2]Br2 (1), [Cu(LH)2]NCS2 (2), and [Cu(LH)2](NO3)2 (3), where LH is the zwitterionic form of 2-bromo-6-((2-(isopropylamino)ethylimino)methyl)phenol (HL), were synthesized and characterized by elemental analysis, IR and UV-vis spectroscopy. The structures of the complexes were further confirmed by single crystal X-ray structure determination. All compounds are mononuclear copper(II) complexes. The Cu atoms in the complexes are coordinated by two imino N and two phenolate O atoms from two LH ligands, forming square planar coordination. The compounds were assayed for their antimicrobial activities.

Synthesis, Characterization, Anti-Glycation, and Anti-Oxidant Activities of Sulfanilamide Schiff Base Metal Chelates

“…12 Copper(II), zinc(II), vanadium(V) and oxidovanadium(V) metal complexes have been reported for their excellent antibacterial urease enzyme inhibition and catalytic properties. [13][14][15][16][17] According to the literature, sulfonamides have a variety of bioactivities, including antitumor, antimalarial, antimicrobial, antithyroid, antidiabetic, anti-HIV/AIDS, anti-parasitic, antiepileptic, and dihydropteroate synthetase inhibitors activities. [18][19][20][21] Sulfonamide metal chelates derivatives have also been reported for their anti-inflammatory, antidiabetic, anti-HIV, anticancer, anticarbonic anhydrase, diuretic, hypoglycemic, antithyroid, antimalarial, antitumor, anti-angiogenic, anti-tubercular, antibacterial, and antifungal activities.…”