Vanadium salts versus diabetes: An overview

Mishra, SK; Kumar, Ashok; Chaturvedi, R. K.; Sn, Pandeya

doi:10.4103/0975-8453.75073

Cited by 6 publications

(6 citation statements)

References 4 publications

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“…Vanadium salts such as sodium orthovanadate mimic several of the metabolic and growth promoting effects of insulin (Mishra et al, 2010;Kumar et al, 2012c). Vanadium is considered as a potential antidiabetic element but it is highly toxic when given in excessive dose to animals and humans (Ghareeb and Hussen, 2008).…”

Section: Introductionmentioning

confidence: 99%

Sodium Orthovanadate and Trigonella Foenum Graecum Prevents Neuronal Parameters Decline and Impaired Glucose Homeostasis in Alloxan Diabetic Rats

Kumar¹,

Taha²,

Kumar³

et al. 2015

Prague Med. Rep.

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Kumar P.; Taha A.; Kumar N.; Kumar V.; Baquer N. Z. Report / Vol. 116 (2015) 122) Prague Medical Key words: Alloxan diabetes -Monoamine oxidase (MAO) -Ca2+ ATPaseAcetylcholinesterase (AChE) -Neurolipofuscin -Sodium orthovanadate (SOV) -Trigonella foenum graecum seed powder (TSP) Abstract: Hyperglycemia is the most important contributor in the onset and progress of diabetic complications mainly by producing oxidative stress. The present study was carried out to observe, the antihyperglycemic effect of sodium orthovanadate (SOV) and Trigonella foenum graecum seed powder (TSP) administration on blood glucose and insulin levels, membrane linked enzymes (monoamine oxidase, acetylcholinesterase, Ca 2+ ATPase), intracellular calcium (Ca 2+ ) levels, lipid peroxidation, membrane fluidity and neurolipofuscin accumulation in brain of the alloxan induced diabetic rats and to see whether the treatment with SOV and TSP was capable of reversing the diabetic effects. Diabetes was induced by administration of alloxan monohydrate (15 mg/100 g body weight) and rats were treated with 2 IU insulin, 0.6 mg/ml SOV, 5% TSP in the diet and a combination of 0.2 mg/ml SOV and 5% TSP separately for three weeks. Diabetic rats showed hyperglycemia with almost four fold high blood glucose levels. Activities of acetylcholinesterase and Ca 2+ ATPase decreased in diabetic rat brain. Diabetic rats exhibited an increased level of intracellular Ca 2+ levels, lipid peroxidation, 123)Prague Medical Report / Vol. 116 (2015) No. 2, p. 122-138 neurolipofuscin accumulations and monoamine oxidase activity. Treatment of diabetic rats with insulin, TSP, SOV and a combined therapy of lower dose of SOV with TSP revived normoglycemia and restored the altered level of membrane bound enzymes, lipid peroxidation and neurolipofuscin accumulation. Our results showed that lower doses of SOV (0.2 mg/ml) could be used in combination with TSP in normalization of altered metabolic parameters and membrane linked enzymes without any harmful side effect.

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Section: Introductionmentioning

confidence: 99%

Sodium Orthovanadate and Trigonella Foenum Graecum Prevents Neuronal Parameters Decline and Impaired Glucose Homeostasis in Alloxan Diabetic Rats

Kumar¹,

Taha²,

Kumar³

et al. 2015

Prague Med. Rep.

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“…However, the average diet provides about 6-20mcg of vanadium per day. 9 Mishra et al, 10 reported that vanadium can activate the tyrosine kinase and glycogen synthase activity of insulin receptors in adipocytes. 10 Vanadium can also increase the concentration of fructose 2, 6-biphosphate which can activate glycolysis in hepatocytes.…”

Section: Introductionmentioning

confidence: 99%

“…9 Mishra et al, 10 reported that vanadium can activate the tyrosine kinase and glycogen synthase activity of insulin receptors in adipocytes. 10 Vanadium can also increase the concentration of fructose 2, 6-biphosphate which can activate glycolysis in hepatocytes. Vanadium salts mimic several of the effects of insulin which include metabolic and growth promoting factors, and have also been shown to stimulate glycogen synthesis in muscles.…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Diet and Vanadyl Sulfate Supplementation on Blood Glucose levels of Diabetics: Review of Current Human Data and Recommendations for Further Study

Shepherd¹

2015

MOJPH

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“…For the same reason, despite of pleiotropic actions, vanadium is not much recommended for any disease or condition. Now there is reconsideration of the compound for use in diabetes mellitus which requires further exploration [5].…”

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confidence: 99%