Vanadium (IV and V) Complexes of Reduced Schiff Bases Derived from the Reaction of Aromatic o‐Hydroxyaldehydes and Diamines Containing Carboxyl Groups

Abstract

The reduced Schiff bases of salicylaldehyde [and o-vanillin (o-van)

Thirty years through vanadium chemistry

“…7 both chloride ions are replaced by H 2 O and the aqueous [V(C 5 H 5 ) 2 ] 2+ binds to DNA, possibly to phosphate groups of nucleotides; thus its behavior differs from that of cisplatin [206]. In vivo vanadocene dichloride was active against several types of tumors and the limiting toxicity appeared to be the injury to liver cells (22)(23)(24)(25)(26)(27) and/or studied for other biological effects [84,163,185,[188][189][190][191][192]. [201,202,204,209]; additionally no transfer of V across the blood-barrier occurred and vanadium was not detected in the brain [202].…”

“…Taking into account their much higher intrinsic stability and much lower susceptibility toward hydrolysis, several publications were released either with characterization of metal complexes [153,[160][161][162][163][164] or using these very versatile ligands to prepare suitable complexes to prepare metal-based catalytic systems [163,[165][166][167][168][169][170][171][172].…”

Vanadium(IV) and ‐(V) Complexes of Reduced Schiff Bases Derived from Aromatic o‐Hydroxyaldehydes and Tyrosine Derivatives

“…However, these Schiff bases (SBs) may hydrolyse in solution, and in many cases it is not possible to characterize either the ligands or their complexes in the solid state. This instability can sometimes be overcome by reduction of the SB at the imine function to give an amine 31–35. A few reduced SBs of salicylaldehyde with amino acids have been isolated,32,33 and their [V V OL(hq)] complexes (Hhq = 8‐hydroxyquinoline) prepared and characterized 33…”