Thirty years through vanadium chemistry

Pessoa, João Costa

doi:10.1016/j.jinorgbio.2015.03.004

Cited by 124 publications

(34 citation statements)

References 260 publications

(392 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Namely, at pH 7.4 there are almost no [V IV O(acac) + ] or [V IV O(acac) 2 ] species in solution. At these low [V IV O(acac) 2 ] concentrations most of V IV O 2+ is in the form of [(VO) 2 (OH) 5 ‐ ] and [VO(OH) 3 ‐ ] …”

Section: Resultsmentioning

confidence: 99%

“…The binding constants of [V IV O(apoHTF)] and [(V IV O) 2 (apoHTF)] are from , are valid at pH 7.4. The formation constants for the system V IV O 2+ +acac are from and the hydrolytic constants for V IV O 2+ from . (a) Distribution of species containing V IV O, (b) Distribution of species containing apoHTF.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the transport of vanadium compounds in blood in vivo, most studies agree that these are predominantly transported bound to serum proteins, particularly HTF . More recently the uptake of V‐species by red blood cells (RBCs) and its possible role was highlighted, but at the low total vanadium concentrations expected in vivo in the blood following oral administration of V antidiabetics, most probably significantly less than ca.…”

Section: Introductionmentioning

confidence: 90%

“…Regarding the transporto fv anadium compounds in blood in vivo, most studies agree that these are predominantly transported bound to serum proteins,p articularly HTF. [24][25][26][27][28][29][30][31][32] More recently the uptake of V-species by red blood cells (RBCs) and its possible role was highlighted, [33][34][35] but at the low total vanadium concentrations expected in vivo in the blood following oral administration of Va ntidiabetics, most probably significantly less than ca. 20 mm even upon oral treatment with aV C, [30,36] HTF appears to be the main vanadium transporter and RBCs possibly play some role in the pharmacokinetics of these compounds and in providing ar educing effect, eventually allowing the formation of V III ,w hich may strongly bind to HTF.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Interaction of [V^IVO(acac)₂] with Human Serum Transferrin and Albumin

Correia

Chorna

Cavaco

et al. 2017

Chemistry An Asian Journal

View full text Add to dashboard Cite

[VO(acac) ] is a remarkable vanadium compound and has potential as a therapeutic drug. It is important to clarify how it is transported in blood, but the reports addressing its binding to serum proteins have been contradictory. We use several spectroscopic and mass spectrometric techniques (ESI and MALDI-TOF), small-angle X-ray scattering and size exclusion chromatography (SEC) to characterize solutions containing [VO(acac) ] and either human serum apotransferrin (apoHTF) or albumin (HSA). DFT and modeling protein calculations are carried out to disclose the type of binding to apoHTF. The measured circular dichroism spectra, SEC and MALDI-TOF data clearly prove that at least two VO-acac moieties may bind to apoHTF, most probably forming [V O(acac)(apoHTF)] complexes with residues of the HTF binding sites. No indication of binding of [VO(acac) ] to HSA is obtained. We conclude that V O-acac species may be transported in blood by transferrin. At very low complex concentrations speciation calculations suggest that [(VO)(apoHTF)] species form.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Interaction of [V^IVO(acac)₂] with Human Serum Transferrin and Albumin

Correia

Chorna

Cavaco

et al. 2017

Chemistry An Asian Journal

View full text Add to dashboard Cite

show abstract

“…Vanadium against certain viruses, bacteria, parasites, and fungi. Based on available literature data[26,33,39,45,[124][125][126][127][128][129][130][131][132][133][134][135][136][137].…”

mentioning

confidence: 99%