Vanadium inhibition of human parietal lobe ATPases

Janiszewska, Grażyna; Lachowicz, Lilla; Jaskólski, Dariusz J.; Gromadzińska, Ewa

doi:10.1016/0020-711x(94)90013-2

Cited by 11 publications

(4 citation statements)

References 21 publications

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“…20) Alternatively, the decline in sperm motil- ity might be due to oxidative stress or impairment of energy generating metabolic enzymes. [21][22][23] A sharp decline in fertility (50% negative) and litter size (p < 0.01) in vanadyl sulphate treated rats might be result of decreased sperm count, motility and alteration in biochemical milieu of genital organs. Similar results were obtained in other studies with vanadium compounds, which have reported an arrest of spermatogenic activity and decline in fertility.…”

Section: Resultsmentioning

confidence: 99%

Reproductive Toxicity of Vanadyl Sulphate in Male Rats

Jain

Pareek

Sharma

et al. 2007

JOURNAL OF HEALTH SCIENCE

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The reproductive functions were evaluated by epididymal sperm counts, motility, fertility rate, reproductive organ weights, biochemistry and histological examination of testes in vanadyl sulphate treated adult male Wistar rats. Oral administration of vanadyl sulphate (100 mg/kg b.wt./day) for 60 days caused a decrease ( p < 0.05) in the weights of testes and accessory reproductive organs. Cauda epididymal sperm analysis exhibited a significant decline in the number ( p < 0.01) and motility ( p < 0.001). Atrophy of seminiferous tubules was observed in histopathological examination. The diameter of seminiferous tubules and Leydig cells nuclei were reduced. Biochemical analysis of marker parameters indicated alteration in biochemical milieu of the genital organs. The mating tests with untreated females revealed a decrease in pregnancy rate and mean number of the pups delivered. As such present investigation indicate an adverse effect of vanadyl sulphate on male reproductive functions.

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Section: Resultsmentioning

confidence: 99%

Reproductive Toxicity of Vanadyl Sulphate in Male Rats

Jain

Pareek

Sharma

et al. 2007

JOURNAL OF HEALTH SCIENCE

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“…Vanadatlar 50 µM derişimde ATPaz'ın daha etkili bir inhibitörüyken vanadil çok düşük derişimde (10 nM) etkili bir inhibitördür (Ivancsits, et. al., 2002;Janiszewska, et. al., 1994).…”

Section: Vanadyumun Organizmalardaki Emilimi Ve Atılımıunclassified

Vanadium

Cevik¹

2014

AKU-J. Sci. Eng.

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Vanadyum, çok farklı yükseltgenme basamağında bulunan, kolay yükseltgenmeyen, korozyona dayanıklı bir geçiş elementidir. Sert ve işlenebilir çelik, seramik, yarı iletken üretimi gibi birçok endüstriyel alanda vanadyum veya bileşikleri kullanılır. Sülfürik asit ve birçok organik bileşiğin üretimi gibi birçok alanda bileşikleri katalizör görevi görür. Canlılarda hücre dışı vücut sıvılarında VO 3 1− , hücre içi vücut sıvılarında ise VO 2+ formunda bulunur. Akciğerlerde çözünebilen vanadyum bileşiklerinin iyi absorbe edilmesine karşın vanadyum tuzları mide ve bağırsakta kolay emilime uğramazlar. Vanadyum muhtemelen temel bir eser element olmasına karşın vanadyum eksikliğinden dolayı herhangi bir hastalık insanlarda tespit edilememiştir. Genel olarak vanadyum bileşiklerinin toksisitesi düşüktür. Vanadyum kanserojen değildir, ancak kanserojen olma olasılığı göz önüne alınmalıdır. Yiyecekler, canlılar için esas vanadyum kaynağıdır. Genellikle vücuttaki vanadyumun fazlasını ortadan kaldırmak için yapılan önlemler gereksizdir çünkü vücutta vanadyum fazla kalmaz. Yani tedaviler destekleyicidir. Askorbik asit ve şelat oluşturucu deferoksamin ve 4,5-dihidroksi-1,3-benzendisülfonik asit bileşikleri vanadyum zehirlenmesine karşı kullanılabilir.

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“…An important physiological role for vanadium was suggested by the finding that it mimics the action of insulin [5,6] as a antidiabetic agent [7]. Vanadium has also been showed to be a potent inhibitor of several phosphohydrolases, such as Na + K + -ATPase and Ca 2+ -ATPase, an activator of adenyl cyclase [8][9][10] and a potent anti-carcinogenic agent [11].…”

Section: Introductionmentioning

confidence: 99%

Dietary Vanadium Induces Decrease in Antioxidant Enzyme Activities and Oxidative Stress in the Spleens of Broilers

Cui¹,

Cui²,

Peng³

et al. 2012

Med Chem

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The purpose of this 42-day study was to evaluate the risk of oxidative stress in the spleens induced by dietary vanadium through determining changes in antioxidant enzymes and oxidation products. A total of 420 one-day-old avian broilers were divided into six groups. There were 70 broilers in each group. The broilers were fed on a cornsoybean basal diet as a control diet (vanadium 0.073 mg/kg) or the same diet amended to contain 5 mg/kg, 15 mg/kg, 30 mg/kg, 45 mg/kg and 60 mg/kg vanadium supplied as ammonium metavanadate (NH 4 VO 3). When compared with those of the control group, the splenic and serum vanadium contents were increased in the 15 mg/kg, 30 mg/kg, 45 mg/ kg and 60 mg/kg groups. Also, the splenic and serum superoxide dismutase (SOD) activities were greatly depressed in the 45 mg/kg and 60 mg/kg groups; the glutathione peroxidase (GSH-Px) activities and the ability to inhibit hydroxyl radical were markedly depressed in the 30 mg/kg, 45 mg/kg and 60 mg/kg groups; the malondialdehyde (MDA) content was significantly increased in the 30 mg/kg, 45 mg/kg and 60 mg/kg groups. At the same time, the splenic glutathione (GSH) content was significantly decreased in the 30 mg/kg, 45 mg/kg and 60 mg/kg groups, and the serum GSH content was significantly decreased in the 15 mg/kg, 30 mg/kg, 45 mg/kg and 60 mg/kg groups. Also, the splenic and serum glutathione (oxidized form, GSSG) content was significantly higher in the 30 mg/kg, 45 mg/kg and 60 mg/ kg groups than that in the control group. These results indicated that dietary vanadium in the range of 30~60 mg/kg caused substantial oxidative stress in the spleen, which then affected the antioxidant function; this may be possible pathway leading to spleen injure. At the same time, it was found that dietary vanadium in the range of 5-15 mg/kg was relatively safe for the spleens of young broilers..

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Vanadium inhibition of human parietal lobe ATPases

Cited by 11 publications

References 21 publications

Reproductive Toxicity of Vanadyl Sulphate in Male Rats

Reproductive Toxicity of Vanadyl Sulphate in Male Rats

Vanadium

Dietary Vanadium Induces Decrease in Antioxidant Enzyme Activities and Oxidative Stress in the Spleens of Broilers

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