Reproductive Toxicity of Vanadyl Sulphate in Male Rats

Jain, Gourav; Pareek, Hemant; Sharma, Sameer; Bhardwaj, Mamta; Khajja, Balvant S.

doi:10.1248/jhs.53.137

Cited by 17 publications

(14 citation statements)

References 29 publications

(20 reference statements)

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“…Therefore, it might be suggested that impaired spermatogenesis further contributes to the declined level of sialic acid in the testes of exposed rats. The results are in accordance with previous researchers who also reported similar decline in sialic acid in testis due to the antiandrogenic or antispermatogenic impact of the metals (Chinoy et al, 2005;Jain et al, 2007). The level of sialic acid was significantly improved in ammonium molybdate treated rats after 60 days of treatment withdrawal probably due to restoration of androgen level.…”

Section: Discussionsupporting

confidence: 92%

Assessment of Molybdenum Induced Alteration in Oxidative Indices, Biochemical Parameters and Sperm Quality in Testis of Wistar Male Rats

Pandey¹,

Jain²

2015

Asian J. of Biochemistry

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The present study was carried out to investigate the effects of ammonium molybdate on lipid peroxidation, antioxidant, biochemical and semen parameters in male Wistar rats. Group I served as control while group II, III and IV received 50, 100 and 150 mg kgG for 60 days and thereafter left for recovery study for 60 days. The present study examined the effects of ammonium molybdate on serum testosterone, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) along with sperm parameters. Estimations were also made for marker biochemical and antioxidant parameters in testis. Ammonium molybdate treatment resulted in a dose dependent reduction in serum testosterone, FSH, LH, sperm count, motility and viability. The concentration of total protein and sialic acid as well as activities of acid phosphatase (ACP) and alkaline phosphatase (ALP) were decreased in a dose dependent manner while there was a significant increase in the glycogen and cholesterol level in testis. The level of Thiobarbituric Acid Reactive substance (TBARs) was increased while the activities of superoxide dismutase and concentration of glutathione and ascorboic acid was decreased significantly in testis of rats treated with ammonium molybdate. All the parameters showed significant improvement after 60 days of treatment withdrawal in highest dose group. The findings suggested that ammonium molybdate exerts a deleterious effect on testicular function by altering biochemical and antioxidant status of the testes.

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Section: Discussionsupporting

confidence: 92%

Assessment of Molybdenum Induced Alteration in Oxidative Indices, Biochemical Parameters and Sperm Quality in Testis of Wistar Male Rats

Pandey¹,

Jain²

2015

Asian J. of Biochemistry

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“…Considering the functional outcomes in other species with similar lesions, these findings suggest that GonaCon-treated EGS males were at least temporarily immunocontracepted. 3,8,13,15 For example, our findings are consistent with those in other animals, such as GonaCon-treated male white-tailed deer, in whom testes size was also reduced as a result of antiGnRH immunocontraception. 2,3 Male EGS normally undergo a semiannual cycle of testicular recrudescence and regression and occasionally skip entire breeding seasons.…”

Section: Discussionsupporting

confidence: 90%

Immunocontraception in Eastern Gray Squirrels (Sciurus carolinensis): Morphologic Changes in Reproductive Organs

Pai¹,

Bruner²,

Schlafer³

et al. 2011

Journal of Zoo and Wildlife Medicine

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Eastern gray squirrels (EGS) (Sciurus carolinensis) damage trees through bark stripping or gnawing due to territorial marking or agonistic gnawing behavior in concert with higher densities. This study was conducted to determine the effects of a contraceptive vaccine on EGS and its reproductive organ histology. Free-ranging urban EGS were vaccinated with the immunocontraceptive GonaCon. All EGS were > or = 6 mo of age as determined by a combination of pelage characteristics and body weights. The vaccine was administered by injection at a dosage rate of 0.4 ml containing 400 microg of GnRH-mollusk protein conjugate i.m. in the thigh to 33 EGS (17 male [m], 16 female [f]) in trapping session 1 (TS1), 23 (14 m, 9 f) in trapping session 2 (TS2), and 11 (8 m, 3 f) in trapping session 3 (TS3). A sham injection containing 0.4 ml saline-AdjuVac was given as control to 22 EGS (16 m, 6 f) in TS1, 20 (12 m, 8 f) in TS2, and 8 (4 m, 4 f) in TS3. In the last trapping session (TS4), 35 EGS (16 treated, 19 control) were killed for necropsy to evaluate histologic changes in testes and ovaries. Treated EGS males had testicular, prostatic, and epididymal atrophy compared with control EGS males. The tubuli seminiferi and prostatic glandular lumen of treated EGS males were atrophic, and the epididymal lumen contained no sperm cells. No histologic changes were observed in treated EGS females; however, females likely were not collected when changes due to GonaCon would have been observed. There were no observable histologic differences in the pituitary gland of treated and control EGS. There were no statistically significant differences in either testosterone or progesterone concentrations between control and treated EGS. Although there were no serious side effects to the vaccine, six EGS developed injection site abscesses. GonaCon may be a potential tool for EGS population control.

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“…In particular, decreased reproductive performance of male rats and mice (mated with naïve females), was reported following oral exposure to vanadyl sulfate or sodium metavanadate, respectively, for 8–9 weeks [10], [11]. Weight changes in male reproductive-associated organs were not observed in the current studies, however more comprehensive assessment of effects on spermatogenesis would be needed to confirm whether or not vanadium has an impact on male reproductive performance.…”

Section: Discussionmentioning

confidence: 53%

“…Several studies in the literature, have reported effects of vanadium on developmental and reproductive endpoints following oral exposure [7], [10], [11], [21]. In particular, decreased reproductive performance of male rats and mice (mated with naïve females), was reported following oral exposure to vanadyl sulfate or sodium metavanadate, respectively, for 8–9 weeks [10], [11].…”

Section: Discussionmentioning

confidence: 99%

14-day toxicity studies of tetravalent and pentavalent vanadium compounds in Harlan Sprague Dawley rats and B6C3F1/N mice via drinking water exposure

et al. 2016

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BackgroundThe National Toxicology Program (NTP) performed short-term toxicity studies of tetra- and pentavalent vanadium compounds, vanadyl sulfate and sodium metavanadate, respectively. Due to widespread human exposure and a lack of chronic toxicity data, there is concern for human health following oral exposure to soluble vanadium compounds.ObjectivesTo compare the potency and toxicological profile of vanadyl sulfate and sodium metavanadate using a short-term in vivo toxicity assay.MethodsAdult male and female Harlan Sprague Dawley (HSD) rats and B6C3F1/N mice, 5 per group, were exposed to vanadyl sulfate or sodium metavanadate, via drinking water, at concentrations of 0, 125, 250, 500, 1000 or 2000 mg/L for 14 days. Water consumption, body weights and clinical observations were recorded throughout the study; organ weights were collected at study termination.ResultsLower water consumption, up to −80% at 2000 mg/L, was observed at most exposure concentrations for animals exposed to either vanadyl sulfate or sodium metavanadate and was accompanied by decreased body weights at the highest concentrations for both compounds. Animals in the 1000 and 2000 mg/L sodium metavanadate groups were removed early due to overt toxicity. Thinness was observed in high-dose animals exposed to either compound, while lethargy and abnormal gait were only observed in vanadate-exposed animals.ConclusionsBased on clinical observations and overt toxicity, sodium metavanadate appears to be more toxic than vanadyl sulfate. Differential toxicity cannot be explained by differences in total vanadium intake, based on water consumption, and may be due to differences in disposition or mechanism of toxicity.

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Reproductive Toxicity of Vanadyl Sulphate in Male Rats

Cited by 17 publications

References 29 publications

Assessment of Molybdenum Induced Alteration in Oxidative Indices, Biochemical Parameters and Sperm Quality in Testis of Wistar Male Rats

Assessment of Molybdenum Induced Alteration in Oxidative Indices, Biochemical Parameters and Sperm Quality in Testis of Wistar Male Rats

Immunocontraception in Eastern Gray Squirrels (Sciurus carolinensis): Morphologic Changes in Reproductive Organs

14-day toxicity studies of tetravalent and pentavalent vanadium compounds in Harlan Sprague Dawley rats and B6C3F1/N mice via drinking water exposure

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