Values and Preferences on the Use of Oral Pre-exposure Prophylaxis (PrEP) for HIV Prevention Among Multiple Populations: A Systematic Review of the Literature

Koechlin, Florence; Fonner, Virginia A.; Dalglish, Sarah L; O’Reilly, Kevin; Baggaley, Rachel; Grant, Robert M.; Rodolph, Michelle; Hodges-Mameletzis, Ioannis; Kennedy, Caitlin E.

doi:10.1007/s10461-016-1627-z

Cited by 167 publications

(130 citation statements)

References 73 publications

(68 reference statements)

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“…Finally, the PrEP users who participated in our study identified an important role for peer support in initiating and continuing PrEP use and expressed significant enthusiasm for sharing their own experiences. This finding adds to previous research demonstrating that peer support or approval can facilitate PrEP uptake (Hannaford et al, 2018;Koechlin et al, 2017). While peer-to-peer or patient navigation interventions are recommended for promoting retention in HIV care, more research is needed to explore how similar interventions may be used to support PrEP use.…”

Section: Discussionsupporting

confidence: 51%

“Little Tablets of Gold”: An Examination of the Psychological and Social Dimensions of PrEP Among LGBTQ Communities

Sun

Anderson

Toevs

et al. 2019

AIDS Education and Prevention

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There are significant psychological, social, and cultural dimensions to the HIV epidemic in the United States, especially among lesbian, gay, bisexual, transgender, and queer (LGBTQ) communities. Biomedical HIV treatment has been shown to impact these dimensions. However, there is little understanding of the real-world psychosocial and sociocultural effects of the latest biomedical HIV prevention strategy, HIV pre-exposure prophylaxis (PrEP). This study explored the psychosocial and sociocultural dimensions of PrEP use among LGBTQ adults. We interviewed 23 LGBTQ adults who were current or former users of PrEP. Results included that PrEP users' experiences were shaped by multiple forms of stigma. Participants were highly motivated to challenge PrEP stigma and to support PrEP use among other community members.Lastly, participants described positive impacts on their individual well-being and their sexual partnerships. Findings suggest that PrEP has significant impacts beyond biomedical outcomes for both the individuals who use PrEP and their communities.

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Section: Discussionsupporting

confidence: 51%

“Little Tablets of Gold”: An Examination of the Psychological and Social Dimensions of PrEP Among LGBTQ Communities

Sun

Anderson

Toevs

et al. 2019

AIDS Education and Prevention

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“…Additionally, three other papers noted that risk behaviour did not change over time among participants actually using PrEP including migrant workers and female partners, MSM, FSW and serodiscordant couples [36,42,43]. It should also be noted that two systematic reviews also have shown no significant changes in behaviour among PrEP users [1,17].…”

Section: Realities and Compensationmentioning

confidence: 99%

Understanding user perspectives of and preferences for oral PrEPforHIVprevention in the context of intervention scale‐up: a synthesis of evidence from sub‐Saharan Africa

2019

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Introduction Oral pre‐exposure prophylaxis (Pr EP ) for HIV prevention has been proven to significantly reduce new HIV infections yet scale‐up has been slow. As contexts continue to adjust to make space for Pr EP , it is crucial to understand the perspectives and experiences of potential end‐users. In order to inform Pr EP and demand creation interventions, this paper examines personal perspectives on adopting and using Pr EP among HIV at‐risk populations in sub‐Saharan Africa. Methods Using the principles of a scoping review in July 2018, we explored the extent, range, and nature of published literature regarding Pr EP uptake and use among; men who have sex with men, HIV serodiscordant couples, adolescent girls and young women, pregnant and breastfeeding women, women partners of migrant workers; and people who use drugs. Steps included: identification of the research question; identification of relevant studies; study selection; charting the data; and collation – summarizing and reporting results. PubMed and PsycInfo were searched for papers relating to Pr EP uptake and use in sub‐Saharan Africa. Resulting papers were reviewed with data extracted and compiled in Excel for analysis. A broad content analysis was conducted and organized into high‐level themes. Results and discussion Thirty‐five papers were included in this review. There was little opposition in general to oral Pr EP ; however, there were significant nuances in its broader acceptability, applicability, and usability. We identified five themes within which these are discussed. These relate to balancing complexities of personal empowerment and stigma; navigating complex risk environments; influences of relationships and partners; efficacy and side effects; and practicalities of use. This body of research suggests that while product attributes and the logistics of Pr EP delivery and use are important topics, it is vital to consider stigma, the interactions of Pr EP use with relationships, and the need for broader understanding of ARV s for prevention versus treatment. Conclusions Planning for, programming and promoting the adoption of oral Pr EP necessitates a deeper understanding of end‐user priorities in order to ensure successful interventions. This review illustrates the nuances facilitating or deterring Pr EP use that may affect the larger effort of Pr EP scale‐up.

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“…A systematic review described strong interest and support for PrEP use among many younger populations at risk of HIV infection including adolescent girls and young women, youth who identify as transgender, and, to a lesser extent, youth who inject drugs [26]. Two recent mixed-method studies of MSM, one in Kenya and one in the UK, found that younger men were more willing than older MSM to take daily oral PrEP [27, 28].…”

Section: Other Considerations Regarding Prep For Youthmentioning

confidence: 99%

HIV preexposure prophylaxis for adolescents and young adults

Allen

Gordon

Krakower

et al. 2017

Current Opinion in Pediatrics

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STRUCTURED ABSTRACT Purpose of review This review describes the evidence for HIV pre-exposure prophylaxis (PrEP) with daily combined tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) in adolescents and young adults. Current recommendations are described, as are the unique medical, socioeconomic, and legal considerations regarding the use of PrEP for youth. Recent findings PrEP with daily oral TDF-FTC has been shown to help prevent new HIV infection among adults at substantial risk. Evidence suggests a protective benefit of PrEP for youth at risk for HIV, although low adherence is emerging as a barrier to effective use. Summary Effective use of antiretrovirals for PrEP represents a seminal development in HIV prevention efforts. Improving access and adherence to PrEP for youth has the potential to substantially reduce the incidence of HIV in this population.

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Values and Preferences on the Use of Oral Pre-exposure Prophylaxis (PrEP) for HIV Prevention Among Multiple Populations: A Systematic Review of the Literature

Cited by 167 publications

References 73 publications

“Little Tablets of Gold”: An Examination of the Psychological and Social Dimensions of PrEP Among LGBTQ Communities

“Little Tablets of Gold”: An Examination of the Psychological and Social Dimensions of PrEP Among LGBTQ Communities

Understanding user perspectives of and preferences for oral PrEPforHIVprevention in the context of intervention scale‐up: a synthesis of evidence from sub‐Saharan Africa

HIV preexposure prophylaxis for adolescents and young adults

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