Value of spectral detector computed tomography for assessment of pancreatic lesions

Kayal, Nada El; Lennartz, Simon; Ekdawi, Sandra N.; Holz, Jasmin A.; Slebocki, Karin; Haneder, Stefan; Wybranski, Christian; Mohallel, Ahmed; Eid, Mohamed; Grüll, Holger; Persigehl, Thorsten; Borggrefe, Jan; Maintz, David; Heneweer, Carola

doi:10.1016/j.ejrad.2019.07.016

Cited by 20 publications

(16 citation statements)

References 37 publications

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“…MEI (+) was reconstructed at 40, 50, 60, 70, and 80 keV levels, as well as ID and Zeff series and IO images. No reconstructions at higher keV levels were performed, as previous studies have suggested that optimal keV levels range from 40 to 70 keV (9,17). ID images are materialspecific images calculated from two different energetic datasets (100% iodine concentration); when fused with regular grayscale conventional images, leading to IO images, the iodine concentration appears color-coded (50% iodine concentration).…”

Section: Dect Image Reconstructionmentioning

confidence: 99%

Subjective and Objective Assessment of Monoenergetic and Polyenergetic Images Acquired by Dual-Energy CT in Breast Cancer

et al. 2021

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Objective To objectively and subjectively assess and compare the characteristics of monoenergetic images [MEI (+)] and polyenergetic images (PEI) acquired by dual-energy CT (DECT) of patients with breast cancer. Materials and Methods This retrospective study evaluated the images and data of 42 patients with breast cancer who had undergone dual-phase contrast-enhanced DECT from June to September 2019. One standard PEI, five MEI (+) in 10-kiloelectron volt (keV) intervals (range, 40–80 keV), iodine density (ID) maps, iodine overlay images, and Z effective (Z eff ) maps were reconstructed. The contrast-to-noise ratio (CNR) and the signal-to-noise ratio (SNR) were calculated. Multiple quantitative parameters of the malignant breast lesions were compared between the arterial and the venous phase images. Two readers independently assessed lesion conspicuity and performed a morphology analysis. Results Low keV MEI (+) at 40–50 keV showed increased CNR and SNR breast lesion compared with PEI, especially in the venous phase ([CNR: 40 keV, 20.10; 50 keV, 14.45; vs. PEI, 7.27; p < 0.001], [SNR breast lesion : 40 keV, 21.01; 50 keV, 16.28; vs. PEI, 10.77; p < 0.001]). Multiple quantitative DECT parameters of malignant breast lesions were higher in the venous phase images than in the arterial phase images ( p < 0.001). MEI (+) at 40 keV, ID, and Z eff reconstructions yielded the highest Likert scores for lesion conspicuity. The conspicuity of the mass margin and the visual enhancement were significantly better in 40-keV MEI (+) than in the PEI ( p = 0.022, p = 0.033, respectively). Conclusion Compared with PEI, MEI (+) reconstructions at low keV in the venous phase acquired by DECT improved the objective and subjective assessment of lesion conspicuity in patients with malignant breast lesions. MEI (+) reconstruction acquired by DECT may be helpful for the preoperative evaluation of breast cancer.

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Section: Dect Image Reconstructionmentioning

confidence: 99%

Subjective and Objective Assessment of Monoenergetic and Polyenergetic Images Acquired by Dual-Energy CT in Breast Cancer

et al. 2021

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“…Subsequently, other authors have also shown improvements in image quality [50,51], lesion conspicuity [52][53][54], and evaluation of vascular involvement [55] using noiseoptimized lower energy (40-55 keV) monochromatic images and iodine maps [55,56].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Clinical Implementation of Dual-Energy CT for Gastrointestinal Imaging

Mileto

Ananthakrishnan

Morgan

et al. 2021

American Journal of Roentgenology

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The publication of this Accepted Manuscript is provided to give early visibility to the contents of the article, which will undergo additional copyediting, typesetting, and review before it is published in its final form. During the production process, errors may be discovered that could affect the content of the Accepted Manuscript. All legal disclaimers that apply to the journal pertain. The reader is cautioned to consult the definitive version of record before relying on the contents of this document.

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“…PDAC is usually hypovascular, if compared to normal parenchyma, due to the high percentage of associated desmoplasia and fibrosis (34). However, on CT, a significant proportion of focal lesions are slightly hypo-or isodense to the pancreatic parenchyma, making difficult their detection (35). For this reason, many studies have investigated the feasibility of virtual monoenergetic series and iodine maps, in terms of signal and CNR, in pancreatic cancer evaluation (35)(36)(37)(38)(39)(40)(41).…”

Section: Pancreasmentioning

confidence: 99%

“…However, on CT, a significant proportion of focal lesions are slightly hypo-or isodense to the pancreatic parenchyma, making difficult their detection (35). For this reason, many studies have investigated the feasibility of virtual monoenergetic series and iodine maps, in terms of signal and CNR, in pancreatic cancer evaluation (35)(36)(37)(38)(39)(40)(41). Bhosale et al (38), in 2015, compared CNR and signal to noise ratio (SNR) between DECT and 120 kVp CT images in pancreatic phase, in patients with PDAC.…”

Section: Pancreasmentioning

confidence: 99%

“…Subjective image quality was assessed using a 5-point Likert scale and 40-50 keV images were considered the best for evaluating PDAC. El Kayal et al (35), in 2019, analyzed 61 patients with pancreatic lesions of different origins, who underwent DECT scans in portal venous phase. The authors found that lesion conspicuity was significantly higher on monoenergetic images at 40 keV, iodine density and iodine overlay reconstructions.…”

Section: Pancreasmentioning

confidence: 99%

See 1 more Smart Citation

Dual energy CT in gland tumors: a comprehensive narrative review and differential diagnosis

Gentili¹,

Guerrini²,

Mazzei³

et al. 2020

Gland Surg

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Dual energy CT (DECT)with image acquisition at two different photon X-ray levels allows the characterization of a specific tissue or material/elements, the extrapolation of virtual unenhanced and monoenergetic images, and the quantification of iodine uptake; such special capabilities make the DECT the perfect technique to support oncological imaging for tumor detection and characterization and treatment monitoring, while concurrently reducing the dose of radiation and iodine and improving the metal artifact reduction. Even though its potential in the field of oncology has not been fully explored yet, DECT is already widely used today thanks to the availability of different CT technologies, such as dual-source, singlesource rapid-switching, single-source sequential, single-source twin-beam and dual-layer technologies.Moreover DECT technology represents the future of the imaging innovation and it is subject to ongoing development that increase according its clinical potentiality, in particular in the field of oncology. This review points out recent state-of-the-art in DECT applications in gland tumors, with special focus on its potential uses in the field of oncological imaging of endocrine and exocrine glands.

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Value of spectral detector computed tomography for assessment of pancreatic lesions

Cited by 20 publications

References 37 publications

Subjective and Objective Assessment of Monoenergetic and Polyenergetic Images Acquired by Dual-Energy CT in Breast Cancer

Subjective and Objective Assessment of Monoenergetic and Polyenergetic Images Acquired by Dual-Energy CT in Breast Cancer

Clinical Implementation of Dual-Energy CT for Gastrointestinal Imaging

Dual energy CT in gland tumors: a comprehensive narrative review and differential diagnosis

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