Value of Serum Growth Differentiation Factor 15 in diagnosis of Colorectal Cancer

Magneto-controlled electrochemical immunosensing platform to assess the senescence-associated GDF-15 marker in colorectal cancer

“…54,55 These results are perfectly in line with the valuable potential of GDF-15 for CRC detection and prognosis. 14,17,20,21,22,47,[56][57][58][59][60] Indeed, it has been reported that GDF-15 levels in serum gradually increase in the process of conversion from adenomatous polyps to colorectal carcinoma 14,59 and that CRC patients with an increased serum level of GDF-15 had a 2.09-fold higher risk of death 11 and worse cancer-specific survival (CSS). 21 In our results, this would correspond to the CRC plasma samples at advanced stages (1.85-fold higher GDF-15 plasma values than healthy individuals).…”