Value of neutrophil-to-platelet ratio, immature granulocyte-to-lymphocyte ratio, red blood cell distribution width-to-lymphocyte ratio in differentiating complicated acute appendicitis

Kubat, Mehmet; Şengül, Serkan

doi:10.14744/tjtes.2022.30434

Cited by 3 publications

(6 citation statements)

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“…18 Neutrophil-toplatelet ratio (NPR) was found beneficial in differentiating between complicated or uncomplicated acute appendicitis. 19 Platelet activation also plays a role in the worsening coagulation disorders in systemic inflammatory reactions, and lymphopenia could reflect the immunosuppressive status in severe infections. Therefore, a high platelet-tolymphocyte ratio (PLR) is a promising biomarker for predicting sepsis severity.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, the neutrophil‐to‐lymphocyte ratio (NLR) could predict severity and death in patients with SJS/TEN 18 . Neutrophil‐to‐platelet ratio (NPR) was found beneficial in differentiating between complicated or uncomplicated acute appendicitis 19 . Platelet activation also plays a role in the worsening coagulation disorders in systemic inflammatory reactions, and lymphopenia could reflect the immunosuppressive status in severe infections.…”

Section: Introductionmentioning

confidence: 99%

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Key factors predicting the in‐hospital mortality of patients with severe cutaneous adverse reactions in Thailand

Chuenboonngarm

Puaratanaarunkon

Washrawirul

et al. 2023

Acad Dermatol Venereol

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BackgroundAt present, no predictive models are available to determine the probability of in‐hospital mortality rates (HMRs) in all phenotypes of severe cutaneous adverse reactions (SCARs).ObjectivesOur study explored whether simple clinical and laboratory assessments could help predict the HMRs in any phenotypes of SCAR patients.MethodsFactors influencing HMRs in 195 adults diagnosed with different SCAR phenotypes were identified, and their optimal cut‐offs were determined by Youden's index. Predictive equations for HMRs for all SCAR patients and Stevens‐Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) patients were determined using the exact logistic regression models.ResultsAcute generalized exanthematous pustulosis (AGEP) patients were significantly older, with a short time from drug exposure to reaction, and higher neutrophil count compared to SJS/TEN and drug reaction with eosinophilia and systemic symptoms (DRESS, p < 0.001). Peripheral blood eosinophilia, atypical lymphocytosis and elevated liver transaminase enzymes were significantly higher in DRESS. SJS/TEN phenotype, age ≥ 71.5 years, neutrophil‐to‐lymphocyte ratio ≥ 4.08 (high NLR) and systemic infection were factors predicting in‐hospital mortality in all SCAR subjects. The ALLSCAR model developed from these factors demonstrated high‐diagnostic accuracy for predicting HMRs in all SCAR phenotypes (area under the receiver‐operator curve (AUC) = 0.95). The risk of in‐hospital death was significantly increased in SCAR patients with high NLR after adjusting for systemic infection. The model derived from high NLR, systemic infection and age yielded higher accuracy than SCORTEN (AUC = 0.77) for predicting the HMRs in SJS/TEN patients (AUC = 0.97).ConclusionsBeing older, having systemic infection, having a high NLR and SJS/TEN phenotype increases ALLSCAR scores, which in turn increases the risk of in‐hospital mortality. These basic clinical and laboratory parameters can easily be obtained in any hospital setting. Despite its simple approach, further validation of the model is warranted.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Key factors predicting the in‐hospital mortality of patients with severe cutaneous adverse reactions in Thailand

Chuenboonngarm

Puaratanaarunkon

Washrawirul

et al. 2023

Acad Dermatol Venereol

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“…Immature granulocytes were reported to be higher in peripheral blood mainly in diseases such as sepsis, acute infections, and acute appendicitis [15,16]. Immature granulocytes include metamyelocytes, myelocytes, and promyelocytes; they are precursors of neutrophils and they indicate increased bone marrow activity [17].…”

Section: Discussionmentioning

confidence: 99%

“…The immature/mature granulocyte ratio was reported to increase in some hematological and autoimmune diseases and be an important bioindicator [17,18]. Moreover, it was stated that it can be defined as both early diagnosis and prognosis bioindicator in sepsis and surgical diseases such as acute pancreatitis and acute appendicitis [15,19]. However, in the literature, there is no study examining this parameter in relation to headaches.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory and infectious parameters in tension-type headache

Yilmaz

2023

Health Sci. Q.

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Although tension-type headache (TTH) is the most common primary headache in the world, much fewer studies on its pathophysiology have been carried out in comparison to other primary headaches. Inflammatory processes are important in the pathophysiology of both peripheral and central pain. Studies on the role of inflammatory markers in TTH patients are limited. Therefore, in this study, it was aimed to examine the role of inflammatory parameters in TTH. 199 TTH patients and 154 control participants were involved in this study. C-reactive protein (CRP) and high-density lipoprotein (HDL) levels and neutrophil/lymphocyte (NLR), platelet/lymphocyte (PLR), monocyte/lymphocyte (MLR), HDL/monocyte and Immature/Total granulocyte ratios in all patients reviewed retrospectively. CRP value and immature/total granulocyte ratio were found to be significantly higher in the patient group when compared to the control group. No difference was found between NLR, PLR, MLR, and HDL/Monocyte ratios. There was no difference in NLR, MLR, immature/mature granulocyte ratios, and CRP values between the genders in the patient group. Median values of PLR, HDL, and HDL / monocyte were found to be higher in males. The fact that there is no difference in most of the inflammatory parameters in TTH and there is a significant difference in the immature/total granulocyte ratio is a new finding on this subject. There is no other study in the literature examining the immature/total granulocyte ratio in headaches.

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“…In studies, many parameters such as WBC, CRP, delta neutrophil index (DNI), neutrophils, and NLR were compared with each other and evaluated in the distinction of CA and UCA. [15][16][17][18][19] A higher inflammatory response in CA cases causes higher inflamma- tory biomarkers to be detected in CA cases. The increase in circulating IG is a reaction of the blood marrow to bacterial infection.…”

Section: Discussionmentioning

confidence: 99%

The Role of Immature Granulocyte in Patients with Complex Appendicitis

Kalafat¹

2023

Comprehensive Med

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Objective:The most frequent cause of emergency abdominal surgeries is acute appendicitis (AA). Biomarkers are utilized by clinicians to aid in predicting acute or perforated appendicitis, which may influence treatment decisions. This study aims to examine the potential of immature granulocyte (IG), a robust marker of inflammatory response, in anticipating the occurrence of complications in patients with AA. Materials and Methods:This retrospective study covering 1 year was performed with patients who were operated on by general surgery with a preliminary diagnosis of AA. The study was conducted with a total of 470 patients, 303 of whom were uncomplicated and 167 were complicated, whose diagnosis was confirmed by pathology reports and met the inclusion criteria. White blood cell (WBC), C-reactive protein, neutrophil, platelet, red cell distribution width, IG numbers, and percentages of the patients were recorded in the study form.Results: Arean under the curve values of WBC, neutrophil, and IG numbers were 0.590, 0.588, and 0.559, respectively, and we found that they were statistically significant. Each unit increase in the number of IG increases the probability of complication in appendicitis cases approximately 3333 times. Conclusion:In this study, we have demonstrated that the probability of having a complicated appendicitis (CA) is higher in AA patients with higher IG levels when distinguishing between complicated and in CA. Together with physical examination, imaging studies, and other laboratory tests, IG values can assist clinicians in identifying high-risk AA patients in the emergency department.

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Value of neutrophil-to-platelet ratio, immature granulocyte-to-lymphocyte ratio, red blood cell distribution width-to-lymphocyte ratio in differentiating complicated acute appendicitis

Cited by 3 publications

References 0 publications

Key factors predicting the in‐hospital mortality of patients with severe cutaneous adverse reactions in Thailand

Key factors predicting the in‐hospital mortality of patients with severe cutaneous adverse reactions in Thailand

Inflammatory and infectious parameters in tension-type headache

The Role of Immature Granulocyte in Patients with Complex Appendicitis

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