Value of neutrophil/lymphocyte ratio in the differential diagnosis of sarcoidosis and tuberculosis

Iliaz, Sinem; İliaz, Raim; Ortakoylu, Gonenc; Bahadır, Ayşe; Bagci, Belma Akbaba; Caglar, Emel

doi:10.4103/1817-1737.140135

Cited by 68 publications

(78 citation statements)

References 18 publications

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“…It can be easily calculated from a routine complete blood count and is determined by dividing the absolute neutrophil count by the number of lymphocytes. In a Turkish study that compared sarcoidosis and control groups, neutrophil count, NLR and CRP were significantly higher, and lymphocytes were significantly lower in the sarcoidosis group [20]. Additionally, Dirican et al [21] concluded that a higher NLR (≥2) was detected in patients with sarcoidosis and that this was more frequent in patients with extrapulmonary involvement.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of Age Distribution and Disease Presentation of 1269 Patients with Sarcoidosis

et al. 2017

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Objective: While the incidence of sarcoidosis peaks between 20 and 39 years, it is comparatively low in elderly subjects. We sought to determine whether there are age-dependent differences in the demographic and laboratory characteristics of patients with sarcoidosis. Materials and Methods: We retrospectively collected information from our database using the International Classification of Disease (ICD) diagnostic code D86 between 2008 and 2014. Patients were divided into three groups: 20-39 years old (Group 1), 40-59 years old (Group 2), and 60-80 years old (Group 3). Results: A total of 3988 patients with code of D86 were included in the study. After the exclusion of noneligible patients, the number of cases in Groups 1, 2, and 3 were 276, 641, and 352, respectively. The groups were compared according to demographic characteristics, ICD diagnostic codes, and laboratory parameters. The ratio of female patients was significantly higher in Group 3 than in Groups 1 and 2 (p=0.000). There was no difference in diagnostic codes of the ICD subgroups between groups (p=0.19). While the level of bloodurea nitrogen was significantly higher in Group 3 patients than in other groups (p=0.000), serum angiotensinconverting enzyme (ACE) values were found to be significantly low in Group 3 (p=0.010). The mean ACE values did not differ between females and males (50.8±39.3 and 59.1±45.5 mg/dL, respectively) (p=0.18). Conclusion:The majority of patients with sarcoidosis were female in all age groups and pulmonary sarcoidosis was the most common presentation of the disease. Elderly patients (≥60 years) with sarcoidosis had lower serum ACE levels than younger patients.

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Section: Discussionmentioning

confidence: 99%

“…The NLR has emerged as a new marker of inflammation [20,21]. It can be easily calculated from a routine complete blood count and is determined by dividing the absolute neutrophil count by the number of lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Age Distribution and Disease Presentation of 1269 Patients with Sarcoidosis

et al. 2017

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“…The NLR ratio was calculated by dividing the absolute neutrophil count by the abolute lymphocyte count (12,13).…”

Section: Datamentioning

confidence: 99%

“…The signifi cance of NLR in the diagnosis, follow-up and activity in sarcoidosis is not precisely known. However, there is a limited number of studies that recommend the utilization of Neutrophil/ Lymphocyte ratio in the differential diagnosis and determination of the prognosis (12,13).…”

Section: Introductıonmentioning

confidence: 99%

What is the neutrophil/lymphocyte ratio in sarcoidosis?

Güngör¹,

Aktürk²,

Yalçınsoy³

et al. 2016

BLL

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AIM: Information regarding the Neutrophil/Lymphocyte ratio (NLR) in sarcoidosis and the data from studies recommending its use as an indicator of infl ammation and in the differential diagnosis and prognosis, are limited. With this study, it was aimed to obtain data regarding the NLR level in the patients at the time of presentation to the hospital and to determine the characteristics of patients in whom the NLR value was > 2. RESULTS: During the study period, of the 3434 patients with the sub-diagnosis of D86, 1300 cases whose complete blood count values had been recorded at the time of presentation were included in the study. Of the cases, 40 % were pulmonary sarcoidosis, 7 % were pulmonary sarcoidosis with sarcoidosis of the lymph nodes, 8 % were lymph node sarcoidosis, 1 % were sarcoidosis, of other combined areas, and 40 % of the cases were sarcoidosis that were unspecifi ed. The F/M of the cases were 947/353, and the average age of the cases was 44. When the sarcoidosis groups were grouped into NLR < 2 (Group 1) and NLR ≥ 2 (Gorup 2), 27 % were Group 1, 73 % were Group 2, and a signifi cant correlation was found between the two groups. When the infl ammatory indicators were compared with NLR, the PLT/MPV was found to be statistically insignifi cant, and the ACE, ESR and CRP were found to be statistically signifi cant. CONCLUSION: The Neutrophil/Lymphocyte ratio in the complete blood count, which is an easy and cheap test, can be used as an indicator of infl ammation in Sarcoidosis. In clinical practice, wide-based studies comprising the activity and the staging in the prognosis of sarcoidosis are required (Tab. 2, Fig. 2, Ref. 26). Text in PDF www.elis.sk.

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“…Some recent studies have shown that NLR and PLR have a diagnostic value in certain pathologies characterised by systemic or local inflammatory response, such as diabetes mellitus, coronary artery disease, ulcerative colitis, sarcoidosis, tuberculosis and inflammatory arthritis (5)(6)(7)(8)(9)(10) .…”

Section: Introductionmentioning

confidence: 99%

The Relation of Inflammatory Markers to Idiopathic Pericardial Effusion

Zencir¹

2017

Kosuyolu Heart Journal

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Introduction: With the growing evidence about the role of inflammation on cardiovascular disorders, studies have been focused on inflammatory markers for risk evaluation and disease activity monitoring. The aim of this study was to investigate whether inflammation has a role in idiopathic pericardial effusion (PE) and to reveal its correlation with the disease activity. Patients and Methods:The study population consisted of 107 patients with PE and 35 age-matched and sex-matched healthy volunteers. Each patient underwent a comprehensive clinical evaluation to identify the probable underlying systemic diseases or other potential causes for PE. Results:High-sensitivity C-reactive protein levels (hs-CRP), neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) (p< 0.001 for each) were significantly higher in the PE group than in healthy volunteers. The patients with PE were divided into three subgroups according to the amount of PE. hs-CRP, NLR and PLR significantly correlated with the amount of PE. In the multivariate logistic regression model NLR (OR 1.363, 95% CI 1.026-1.809; p= 0.033) and hs-CRP (OR 1.090, 95% CI 1.030-1.152; p= 0.003) remained as independent predictors of severe PE in patients who have PE.Conclusion: hs-CRP, NLR and PLR may be used for disease activity monitoring, treatment response evaluation and risk stratification of patients with PE.Key Words: High-sensitivity C-reactive protein; neutrophil/lymphocyte ratio; pericardial effusion; platelet/ lymphocyte ratio İdiyopatik Perikardiyal Efüzyon ile İnflamatuvar Belirteçler Arasındaki İlişki ÖZETGiriş: İnflamasyonun kardiyovasküler hastalıklardaki rolü hakkındaki kanıtların gittikçe artmasıyla, çalışma-lar inflamatuvar markerların hastalık aktivitesi ve risk değerlendirmesindeki rolüne odaklanmıştır. Bu çalış-manın amacı inflamatuvar belirteçlerin idiyopatik perikardiyal efüzyonla ile ilişkisini ve hastalık aktivitesi ile olan korelasyonu olup olmadığının incelenmesidir. Hastalar ve Yöntem:Çalışma popülasyonu perikardiyal efüzyonu olan 107 hasta ile yaş ve cinsiyet olarak benzer 35 sağlıklı gönüllülerden oluşmaktadır. Tüm hastalar perikardiyal efüzyonun etyolojisine yönelik kapsamlı bir klinik değerlendirmeye tabi tutulmuştur. Bulgular: Plevral efüzyonu grubunda, yüksek sensitif C-reaktif protein (Hs-CRP), nötrofil/lenfosit oranı (NLR) ve platelet/lenfosit oranı (PLR) (herbiri için p< 0.001), sağlıklı gönüllülerin grubuna göre anlamlı olarak daha yüksekti. Perikardiyal efüzyonu olan hastalar efüzyon miktarına göre 3 gruba bölündü. Hs-CRP, NLR ve PLR perikardiyal efüzyon miktarıyla korele bir şekilde artmaktadır. Çoklu analizde, NLR (OR 1.363, 95% CI 1.026-1.809; p= 0.033) ve Hs-CRP (OR 1.090, %95 CI 1.030-1.152; p= 0.003), perikardiyal efüzyo-nu olan hastalarda ciddi perikardiyal efüzyonun bağımsız bir prediktörleridir.Sonuç: Hs-CRP, NLR ve PLR perikardiyal efüzyonu olan hastalarda, hastalık aktivitesi, tedavi monitörizas-yonunda ve risk sınıflamasında kullanılabilir.Anahtar Kelimeler: Yüksek sensitif C-reaktif protein;

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Value of neutrophil/lymphocyte ratio in the differential diagnosis of sarcoidosis and tuberculosis

Cited by 68 publications

References 18 publications

Analysis of Age Distribution and Disease Presentation of 1269 Patients with Sarcoidosis

Analysis of Age Distribution and Disease Presentation of 1269 Patients with Sarcoidosis

What is the neutrophil/lymphocyte ratio in sarcoidosis?

The Relation of Inflammatory Markers to Idiopathic Pericardial Effusion

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