What is the neutrophil/lymphocyte ratio in sarcoidosis?

Abstract

AIM: Information regarding the Neutrophil/Lymphocyte ratio (NLR) in sarcoidosis and the data from studies recommending its use as an indicator of infl ammation and in the differential diagnosis and prognosis, are limited. With this study, it was aimed to obtain data regarding the NLR level in the patients at the time of presentation to the hospital and to determine the characteristics of patients in whom the NLR value was > 2. RESULTS: During the study period, of the 3434 patients with the sub-diagnosis of D86, 1300 cases whose complete blood count values had been recorded at the time of presentation were included in the study. Of the cases, 40 % were pulmonary sarcoidosis, 7 % were pulmonary sarcoidosis with sarcoidosis of the lymph nodes, 8 % were lymph node sarcoidosis, 1 % were sarcoidosis, of other combined areas, and 40 % of the cases were sarcoidosis that were unspecifi ed. The F/M of the cases were 947/353, and the average age of the cases was 44. When the sarcoidosis groups were grouped into NLR < 2 (Group 1) and NLR ≥ 2 (Gorup 2), 27 % were Group 1, 73 % were Group 2, and a signifi cant correlation was found between the two groups. When the infl ammatory indicators were compared with NLR, the PLT/MPV was found to be statistically insignifi cant, and the ACE, ESR and CRP were found to be statistically signifi cant. CONCLUSION: The Neutrophil/Lymphocyte ratio in the complete blood count, which is an easy and cheap test, can be used as an indicator of infl ammation in Sarcoidosis. In clinical practice, wide-based studies comprising the activity and the staging in the prognosis of sarcoidosis are required (Tab. 2, Fig. 2, Ref. 26). Text in PDF www.elis.sk.

Prognostic value of inflammatory markers determined during diagnosis in patients with sarcoidosis: chronic versus remission

“…The NLR is novel prognostic, diagnostic marker for inflammatory diseases 11,13,14,23 . In the study by İliaz et al, the NLR was found to be supportive in differentiation between tuberculosis and sarcoidosis with the cutoff value of 2.55 13 .…”

“…Neutrophil to lymphocyte ratio (NLR) has been recently emerged as a cost-effective, potential inflammatory marker and found to be associated with the severity and prognosis of systemic inflammatory diseases, cancer, and respiratory and cardiac diseases. Although there are a limited number of studies, NLR was shown to be increased in patients with sarcoidosis as compared with the control group 4,5,13,14 .…”

“…Several clinical, physiological, and radiographic parameters were under investigation for objective disease-specific biomarkers that can predict the severity and prognosis of sarcoidosis 3,4,7,8 . Diagnostic and prognostic roles of inflammatory markers have been addressed by several studies in inflammatory and chronic respiratory diseases 4,5,[9][10][11][12][13][14] . Besides, limited data about serum inflammatory markers were available in the monitoring of patients with sarcoidosis 4,5,9,13,14 .…”

“…Diagnostic and prognostic roles of inflammatory markers have been addressed by several studies in inflammatory and chronic respiratory diseases 4,5,[9][10][11][12][13][14] . Besides, limited data about serum inflammatory markers were available in the monitoring of patients with sarcoidosis 4,5,9,13,14 .…”

Rheumatoid Arthritis and Collagen Vascular In inflammatory disease symptoms, inflammatory markers are different in the presence of respiratory system symptoms

“…The neutrophil/lymphocyte ratio (NLR), platelet count/mean platelet volume (PLT/MPV) ratio, and the platelet count/ lymphocyte ratio (PLR), which may be estimated from hemogram results, have been examined for their role in the diagnosis, treatment response, and severity of respiratory system diseases. NLR, PLR, and PLT/MPV values have been examined in chronic obstructive pulmonary disease (COPD) by investigators at this center, [11][12][13][14] as well as in sarcoidosis [15,16] and interstitial lung diseases. [17] Chronic inflammatory diseases with respiratory system involvement, such as RA and other CVD, are known to have similar symptoms and signs.…”