Value of napsin A and thyroid transcription factor-1 in the identification of primary lung adenocarcinoma

Zhang, Peng; Han, Yongtao; Huang, Ling; Li, Qiang; Ma, Dalie

doi:10.3892/ol_00000160

Cited by 29 publications

(25 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, we consider napsin A to be another suitable marker to specifically distinguish clear cell adenocarcinoma from other ovarian tumors with a relatively high sensitivity. Furthermore, because napsin A is an established marker for lung adenocarcinomas, [7][8][9][10][11][12][13] we assume that napsin A immunostaining will be easily applied to routine surgical pathology specimens in laboratories. In this study, we determined the criteria for positive napsin A immunostaining as 410% tumor area for differential diagnosis between histological subtypes of ovarian adenocarcinomas, and given that focal positivity is observed in those other than clear cell adenocarcinoma, careful interpretation is required when applying this method on small biopsy specimen.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] Napsin A has a role in processing pulmonary surfactant B protein produced by alveolar type II pneumocytes; 5,6 thus, it has been reported to be a good diagnostic marker for the confirmation of primary lung adenocarcinoma together with thyroid transcription factor 1 (TTF-1). [7][8][9][10][11][12][13] Expression of napsin A is also observed in the fetal kidney 14 and proximal tubules of the adult kidney, where it is most likely involved in protein catabolism. 15 In neoplasms other than lung cancer, napsin A expression is most frequently observed in papillary renal carcinoma (79%), followed by other subtypes of renal cell carcinoma and thyroid carcinoma.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Napsin A is a specific marker for ovarian clear cell adenocarcinoma

et al. 2015

View full text Add to dashboard Cite

Ovarian clear cell adenocarcinoma has a relatively poor prognosis among the ovarian cancer subtypes because of its high chemoresistance. Differential diagnosis of clear cell adenocarcinoma from other ovarian surface epithelial tumors is important for its treatment. Napsin A is a known diagnostic marker for lung adenocarcinoma, and expression of napsin A is reported in a certain portion of thyroid and renal carcinomas. However, napsin A expression in ovarian surface epithelial tumors has not previously been examined. In this study, immunohistochemical analysis revealed that in 71 of 86 ovarian clear cell adenocarcinoma patients (83%) and all of the 13 patients with ovarian clear cell adenofibroma, positive napsin A staining was evident. No expression was observed in 30 serous adenocarcinomas, 11 serous adenomas or borderline tumors, 19 endometrioid adenocarcinomas, 22 mucinous adenomas or borderline tumors, 10 mucinous adenocarcinomas, or 3 yolk sac tumors of the ovary. Furthermore, expression of napsin A was not observed in the normal surface epithelium of the ovary, epithelia of the fallopian tubes, squamous epithelium, endocervical epithelium, or the endometrium of the uterus. Therefore, we propose that napsin A is another sensitive and specific marker for distinguishing ovarian clear cell tumors (especially adenocarcinomas) from other ovarian tumors.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Napsin A is a specific marker for ovarian clear cell adenocarcinoma

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The differential expression of TTF-1 and napsin A in different studies may be caused by the quantity of tumor cells available for staining and a relatively small number of cases studied. Recently, Zhang et al (2010) reported that the sensitivity and specificity of napsin A for primary lung AC (84.9 and 93.8%, respectively) were higher than the sensitivity and specificity of TTF-1 (84.4 and 83.9%, respectively). Rossi et al (2009a) demonstrated TTF-1 reactivity in NSCLCs as LCCs and rare cases of SCCs.…”

Section: Discussionmentioning

confidence: 98%

The role of p63, thyroid transcription factor-1, and napsin A immunostaining in the subclassification of nonsmall cell lung carcinomas

Shafeek¹,

Mostafa²

2011

Egyptian Journal of Pathology

View full text Add to dashboard Cite

Background New developments in the treatment of primary lung cancer have necessitated further pathologic subclassification of nonsmall cell lung carcinomas (NSCLC). Certain therapeutic agents should not be used in squamous cell carcinoma or neoplasms with a dominant squamous component. The aim of this study was to identify the value of immunohistochemical markers p63, thyroid transcription factor-1, and napsin A (novel aspartic proteinase of the pepsin family) in the classification of NSCLC into squamous and nonsquamous subtypes. Thirty cases proved to be NSCLC were selected for this study. ResultsOut of 14 squamous cell carcinomas, 12 (85.7%) reacted with p63, whereas only one (7.1%) reacted with thyroid transcription factor (TTF)-1, showing a weak focal staining pattern, and none with napsin A. Out of the 12 adenocarcinomas, eight (66.7%) cases stained for TTF-1, 10 (83.3%) for napsin A, and only one (8.3%) for p63. Out of the four large cell carcinomas, only two (50%) cases reacted with TTF-1, and none with napsin A and p63.Comparing the two markers of lung adenocarcinoma, napsin A showed a higher sensitivity (83.3%) and specificity (100%) than TTF-1 (66.7 and 83.3% respectively). ConclusionThe current results indicate that the use of p63, TTF-1, and napsin A markers may be useful to subclassify NSCLC and to improve therapeutic selection of patients with lung cancer. Egypt J Pathol 31:62-67 c

show abstract

“…Rapid immunostaining is not so popular as HE staining because it requires unconventional antibody, but its method itself have been already established according to the literature; rapid immunostaining of touch imprint cytology for sentinel lymph nodes evaluation in breast cancer for example is in practice in some institutes [11] . By combining TTF-1 and napsin A immunohistochemical analysis is a very sensitive and highly specific method for differential diagnosis of primary and metastatic lung adenocarcinoma [12,13] . About metastatic adenocarcinoma from stomach, Matoso et al showed positive rate of TTF-1 is 1.8% (n = 110) [14] .…”

Section: Discussionmentioning

confidence: 99%

A quick-frozen section diagnosis of a lung tumor in a patient with a gastric cancer history

Yamashita

Funai

Kawase

et al. 2015

CRCP

View full text Add to dashboard Cite

Even in the era of genome-based medicine, daily practices of surgeons and pathologists are full of challenges in making the best management in the circumstances where limited information is available. In this anecdotal experience we'd like to present an instructive case of the patient with past history of distal gastrectomy for gastric cancer, who was pointed out having a synchronous tumorous lesion in the lung during the surveillance. Scrutinized pathological report of the past gastric cancer, staging based on the Japanese Classification Systems, was T2 without lymphatic permeation, and the attending pathologist who saw the intraoperative frozen section showing a mucinous adenocarcinoma had been preoccupied with the metastatic gastric adenocarcinoma and answered so to the surgical team during the operation. Partial resection of the lung is suitable for metastatic tumor, therefore no further procedure was performed. Actually, it was not the metastatic case retrospectively and he needed additional appropriate procedure; lobectomy. We expound the complexities of this case in the hindsight and extract a lesson to both surgeons and pathologists.

show abstract

Value of napsin A and thyroid transcription factor-1 in the identification of primary lung adenocarcinoma

Cited by 29 publications

References 20 publications

Napsin A is a specific marker for ovarian clear cell adenocarcinoma

Napsin A is a specific marker for ovarian clear cell adenocarcinoma

The role of p63, thyroid transcription factor-1, and napsin A immunostaining in the subclassification of nonsmall cell lung carcinomas

A quick-frozen section diagnosis of a lung tumor in a patient with a gastric cancer history

Contact Info

Product

Resources

About