Value of fine needle aspiration biopsy in childhood rhabdomyosarcoma: Twenty‐six years of experience in Slovenia

Abstract

FNAB is a safe method, which enables us to establish the pre-treatment diagnosis of RMS, and to some extent even its type, without delay. In our study, FNAB successfully replaced surgical biopsy in 87% of RMS patients during the last 15 years. Neoadjuvant Cht was started immediately, surgery was delayed and more conservative. Consequently, the risk for treatment sequelae was considerably reduced.

Cyto‐histological correlations in primary, recurrent and metastatic rhabdomyosarcoma: The institut Curie's experience

“…A limited number of studies, including 250 cases, have attempted to characterize the cytologic morphology of RMS. [2][3][4][5][6][7][8][9][10][11][12][13][14][15]19 Cytologic diagnosis in RMS appears to be of great value for the diagnosis of malignancy. Pohar-Marinsek et al 9 and Frostad et al 6 reported 78-80% accuracy and 100% for ''malignant'' diagnosis.…”

“…Over the last two decades, the use of immunocytochemistry to identify muscular markers substantially improves the accuracy of diagnosis. 10,13 FNA material was successfully used in the ancillary techniques to detect the characteristic t(2;13)(q35;q14) chromosomal translocation and/or the gene fusion transcripts PAX-FKHR that are detected with an estimated prevalence of 80% in alveolar subtype RMS. 12,14,15,20,21 In our institution, tumors clinically to be sarcomas were initially sampled using FNA technique to provide immediate diagnosis and sufficient material for ancillary techniques.…”

“…[2][3][4][5][6][7][8][9][10][11][12][13][14][15] A few articles discuss the criteria of morphology related to specific, different RMS histological subtypes, especially in alveolar type RMS. [2][3][4][6][7][8][9]13 The Intergroup of Rhabdomyosarcoma Study 16 recommends the histological classification of RMS into three principal prognostic grades, i.e., superior, intermediate, and poor prognosis, the latter corresponding to alveolar subtype of RMS. For this reason, and in a search for the clinical usefulness of our extensive review, we have subdivided our cases into two main groups: alveolar and nonalveolar subtypes of RMS.…”

Ultrasound‐guided core needle biopsy for the diagnosis of rhabdomyosarcoma in childhood

“…Fine needle aspiration biopsy (FNAB) can be combined with immunocytochemistry in children to diagnose RMS. Pohar-Marinsek et al [19] reported a relatively large series of FNAB in which they were able to make an accurate diagnosis in 29 of 37 (78%) children with suspected RMS, and in 57 of 61 (93%) with recurrent or metastatic disease. At our institution, however, we prefer to use CNB, because it produces sufficient quality and quantity of material for essential conventional and molecular diagnostics, as well as collection of tissue for research.…”

Diagnostic Dilemmas in FNAC Cytology: Small Round Cell Tumours

“…Chemotherapy for RMS may be given before local treatment and prevent mutilating surgery and high-dose irradiation. FNAC can confirm the diagnosis and neoadjuvant treatment can start without delay [16].…”