Value of Electrodiagnostic Assessment in Nonsyndromic Microcephaly

Lo, Atchaneeyasakul; Trinavarat, Adisak; Wanumkarng, N; P, Samsen; Thanasombatsakul, Nualanong

doi:10.1177/112067210301300807

Cited by 1 publication

(1 citation statement)

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“…It has been documented in the past[18] that microcephaly leads to more than 40% reduction in VEP amplitude. The small head size might be a possible cause of reduced VEP amplitudes found in microcephalic children of the present study.…”

Section: Discussionmentioning

confidence: 99%

Neurophysiologic findings in children with spastic cerebral palsy

Kothari

Singh

et al. 2010

J Pediatr Neurosci

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Context:Cerebral palsy (CP) is a heterogeneous group of permanent, non-progressive motor disorders of movement and posture caused by chronic brain injuries. It is the most common cause of physical disability in childhood; spastic cerebral palsy being the most prevalent of its various forms. There is scanty information about the neurophysiologic investigations in children diagnosed as having spastic CP.Aims:The aim of the study was to investigate the relationship between abnormal VEP and BAEP findings with different clinical parameters in children with spastic cerebral palsy.Materials and Methods:Fifteen children with spastic CP in the age range 4 months to 10 years participated in this study. Evaluation of VEPs, brainstem evoked potentials (BAEPs) were performed in all study patients as well as 35 healthy children as controls. The study was conducted after obtaining ethics committee approval and informed consent of parents.Statistical Analysis Used:Significance of difference in the mean values of different parameters in different groups was assessed by Student’s “t” test and the P value <0.05 was considered to be significant. All the values were expressed as mean ± 1 Std. Deviation.Results:A significant difference was found in the VEP latencies and amplitude between the subjects with CP and controls. Striking BAEP abnormalities in CP patients include prolongation of absolute latency of wave V, interpeak latencies of III-V and lowered I-V ratio. Abnormal VEPs and BAEPs in children with bilateral spastic cerebral palsy demonstrated a correlation with the presence of moderate to severe developmental delay.Conclusions:The differences in VEPs and BAEPs were determined between CP children and healthy children. The abnormalities found are probably linked to the neurological deficits present in cases of cerebral palsy.

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Section: Discussionmentioning

confidence: 99%