Value of central vein sign in discriminating multiple sclerosis plaques from other white matter lesions

The “Central Vein Sign” on T2*-weighted Images as a Diagnostic Tool in Multiple Sclerosis: A Systematic Review and Meta-analysis using Individual Patient Data

“…8 (2018)NAWalton Centre and the National Hospital for Neurology and Neurosurgery, UKprospective1841.84:14Darwish EAF, et al . 9 (2018)NAAin Shams University, EgyptNA933 (26–45)2:7Gabr RE, et al . 10 (2018)NAUniversity of Texas Health Science Center at Houston, USAprospective1543 (26–62)6:9Gaitan MI, et al .…”

“…Twelve studies used a 3-Tesla scanner 6–10,12,15,16,18,19,21,24 , four studies used a 7-Tesla scanner 11,14,23,26 , three studies used a 1.5-Tesla scanner 17,22,25 , one study used either 7- or 3-Tesla scanners 13 , and one study used either 3- or 1.5-Tesla scanners 20 . All studies used T2*-based MRI sequences; eight studies used FLAIR and susceptibility-weighted imaging (SWI) 9,13–18,22 , five studies used FLAIR* 7,10,12,20,24 , four studies used T2*-weighted images 11,21,23,26 , three studies used SWI 6,19,25 , and one study used proton density-weighted imaging, T2-weighted imaging, and SWI 8 .…”

“…8 (2018)3 TAchieva, PhilipsPD, T2WI, SWI2 neuroradiologistsyesDarwish EAF, et al . 9 (2018)3 TMagnetom Skyra, SiemensFLAIR, SWI2 neuroradiologistsyesGabr RE, et al . 10 (2018)3 TIngenia, PhilipsFLAIR*1 neuroradiologistNAGaitan MI, et al .…”

“…Eleven original articles evaluated the incidence of central vein sign on T2*-weighted images of patients with non-MS 6–9,15–18,23,25,26 . The pooled incidence of central vein sign on T2*-weighted images was 33% (95% CI, 18–52%).…”

“…Twelve original articles evaluated the overall diagnostic performance of the central vein sign on T2*-weighted images for differentiating MS from other white matter lesions 6–9,12,14,15,20,21,23,24,26 . Four studies included patients with small vessel disease as a comparison group 6,7,21,26 , two studies included patients with NMOSD 8,23 , two studies included patients with CNS inflammatory vasculopathies 9,20 , two studies included healthy controls 12,14 , one study included non-MS white matter lesions 15 , and one study included patients with migraine who had been erroneously diagnosed with MS 24 .…”