Value of 18F-FDG PET/CT in the Detection of Ovarian Malignancy

Park, Taegyu; Lee, Sinae; Park, Soyeon; Lee, Eunsub; Pahk, Kisoo; Rhee, Seunghong; Cho, Jaehyuk; Kim, Chulhan; Eo, Jae Seon; Choe, Jae Gol; Kim, Sungeun

doi:10.1007/s13139-014-0303-3

Cited by 13 publications

(9 citation statements)

References 28 publications

(25 reference statements)

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“…SUV is the radioactivity per unit volume (as a numerator) divided by the injected radioactivity per unit weight (as a denominator). [ 20 , 21 ] SUVmean represents the average radioactivity in the thyroid, and SUVmax reflects the maximum radioactivity in a single voxel within the thyroid. In the present study, SUVmean and SUVmax showed comparable accuracy with the %thyroid uptake in terms of differentiation of thyroid diseases (Fig.…”

Section: Discussionmentioning

confidence: 99%

Quantitative single-photon emission computed tomography/computed tomography for technetium pertechnetate thyroid uptake measurement

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Quantitative single-photon emission computed tomography/computed tomography for technetium pertechnetate thyroid uptake measurement

et al. 2016

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“…These studies included 604 cases. Four of these studies were excluded as we were unable to create two-by-two tables[ 2 20 21 22 ] and one was excluded as it involved staging of mixed gynecological malignancies. [ 8 ] Thus, we included 8 studies and total of 380 patients that were focused on staging OC.…”

Section: Evidence Synthesismentioning

confidence: 99%

Systematic review on the accuracy of positron emission tomography/computed tomography and positron emission tomography/magnetic resonance imaging in the management of ovarian cancer: Is functional information really needed?

et al. 2017

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Ovarian cancer (OC) often presents at an advanced stage with frequent relapses despite optimal treatment; thus, accurate staging and restaging are required for improving treatment outcomes and prognostication. Conventionally, staging of OC is performed using contrast-enhanced computed tomography (CT). Nevertheless, recent advances in the field of hybrid imaging have made positron emission tomography/CT (PET/CT) and PET/magnetic resonance imaging (PET/MRI) as emerging potential noninvasive imaging tools for improved management of OC. Several studies have championed the role of PET/CT for the detection of recurrence and prognostication of OC. We provide a systematic review and meta-analysis of the latest publications regarding the role of molecular imaging in the management of OC. We retrieved 57 original research articles with one article having overlap in both diagnosis and staging; 10 articles (734 patients) regarding the role of PET/CT in diagnosis of OC; 12 articles (604 patients) regarding staging of OC; 22 studies (1429 patients) for detection of recurrence; and 13 articles for prognostication and assessment of treatment response. We calculated pooled sensitivity and specificity of PET/CT performance in various aspects of imaging of OC. We also discussed the emerging role of PET/MRI in the management of OC. We aim to give the readers and objective overview on the role of molecular imaging in the management of OC.

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“…Many studies have been conducted to optimize the effective diagnosis and treatment of ovarian cancer. In a comparison study of 51 patients with peritoneal lesions arising from ovarian cancer, it was demonstrated that the obtained visual results of [ 18 F]FDG PET/CT in association with other semi-quantitative parameters were effective in the detection of ovarian cancer [ 56 ]. This result was based on the observed differentiation potency of [ 18 F]FDG PET/CT in malignant and benign lesions [ 56 ].…”

Section: Ovarian Cancermentioning

confidence: 99%

“…In a comparison study of 51 patients with peritoneal lesions arising from ovarian cancer, it was demonstrated that the obtained visual results of [ 18 F]FDG PET/CT in association with other semi-quantitative parameters were effective in the detection of ovarian cancer [ 56 ]. This result was based on the observed differentiation potency of [ 18 F]FDG PET/CT in malignant and benign lesions [ 56 ]. In another study, results showed that CA125 acted as a sensitive tumor marker of recurrent ovarian cancer in 175 patients with recurrent refractory ovarian cancer and increased carcinoma antigen 125 (CA125).…”

Section: Ovarian Cancermentioning

confidence: 99%

A Review of Nuclear Medicine Approaches in the Diagnosis and the Treatment of Gynecological Malignancies

Vahidfar

Farzanefar

Ahmadzadehfar

et al. 2022

Cancers

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Nuclear medicine is defined as the diagnosis and the treatment of disease using radiolabeled compounds known as radiopharmaceuticals. Single-photon emission computed tomography/computed tomography (SPECT/CT) and positron emission tomography/computer tomography (PET/CT) based radiopharmaceuticals have proven reliable in diagnostic imaging in nuclear medicine and cancer treatment. One of the most critical cancers that also relies on an early diagnosis is gynecological cancer. Given that approximately 25% of all cancers in developing countries are a subset of gynecological cancer, investigating this cancer subtype is of significant clinical worth, particularly in light of its high rate of mortality. With accurate identification of high grade distant abdominal endometrial cancer as well as extra abdominal metastases, 18F-Fluorodeoxyglucose ([18F]FDG) PET/CT imaging is considered a valuable step forward in the investigation of gynecological cancer. Considering these factors, [18F]FDG PET/CT imaging can assist in making management of patient therapy more feasible. In this literature review, we will provide a short overview of the role of nuclear medicine in the diagnosis of obstetric and gynecological cancers.

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Value of 18F-FDG PET/CT in the Detection of Ovarian Malignancy

Cited by 13 publications

References 28 publications

Quantitative single-photon emission computed tomography/computed tomography for technetium pertechnetate thyroid uptake measurement

Quantitative single-photon emission computed tomography/computed tomography for technetium pertechnetate thyroid uptake measurement

Systematic review on the accuracy of positron emission tomography/computed tomography and positron emission tomography/magnetic resonance imaging in the management of ovarian cancer: Is functional information really needed?

A Review of Nuclear Medicine Approaches in the Diagnosis and the Treatment of Gynecological Malignancies

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