Value and Perspectives of Proton Radiation Therapy for Limited Stage Prostate Cancer

Schulte, R.; Slater, Jerry D.; Rossi, Carl J.; Slater, James M.

doi:10.1007/pl00002302

Cited by 45 publications

(27 citation statements)

References 27 publications

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“…In radiation therapy major improvements have been made by the introduction of 3-D conformal therapy techniques especially for prostate cancer [9,12,20]. Many critical parameters have been examined e.g.…”

Section: Discussionmentioning

confidence: 99%

Computed Tomogram prior to Prostatectomy

Höcht

Wiegel²,

Bottke³

et al. 2002

Strahlentherapie und Onkologie

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Section: Discussionmentioning

confidence: 99%

Computed Tomogram prior to Prostatectomy

Höcht

Wiegel²,

Bottke³

et al. 2002

Strahlentherapie und Onkologie

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“…Details of fractionated proton radiation treatment technique and the delivery system employed at our institution have been published previously [24,25]. In brief, all patients underwent thin-cut CT scan of the brain, 512 ϫ 512 matrix, with intravenous contrast.…”

Section: Methodsmentioning

confidence: 99%

Conformal Proton Radiation Therapy for Pediatric Low-Grade Astrocytomas

Hug

Muenter

Archambeau

et al. 2002

Strahlentherapie und Onkologie

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156

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“…Table 4 shows Grade 2 or worse GI and GU morbidity rates after treatment for prostate cancer using modern RT techniques with conventional fractionation or hypofractionation, and C-ion RT has less risk, especially of developing rectal bleeding compared with other RT methods. 30,[42][43][44][45][46][47] These results show that the feasibility of further hypofractionated C-ion RT with 16 fractions is confirmed and that our assumption of RBE of carbon ions and the equivalent dose calculated by the L/Q model are possibly reasonable, even in the case of C-ion RT for prostate cancer, although follow-up times for 63.0 GyE/20 Fr and 57.6 GyE/16 Fr groups seem to be shorter than that for the 66 GyE/20 Fr group.…”

Section: Incidence Of Late Morbiditymentioning

confidence: 99%

Carbon‐ion radiation therapy for prostate cancer

Ishikawa

Tsuji²,

Kamada³

et al. 2012

Int J of Urology

104

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Abbreviations & Acronyms ADT = androgen deprivation therapy bNED = biological relapse free C-ion RT = carbon-ion radiotherapy CSS = cause-specific survival CT = computed tomography CTV = clinical target volume 3D-CRT = three-dimensional conformal radiation therapy DVH = dose-volume histogram Fr = fractions GHMC = Gunma Heavy Ion Medical Center GI = gastrointestinal GS = Gleason score GU = genitourinary Gy = gray GyE = gray equivalents HAMT = Highly Advanced Medical Technology HDR = high-dose-rate HIMAC = Heavy-Ion Medical Accelerator in Chiba IMRT = intensity modulated radiotherapy iPSA = initial serum prostate-specific antigen LET = linear energy transfer L/Q = linear-quadratic NIRS = National Institute of Radiological Sciences PSA = prostate-specific antigen PTV1 = initial planning target volume PTV2 = second planning target volume RBE = relative biological effectiveness RT = radiation therapy RTOG = Radiation Therapy Oncology Group SBRT = stereotactic body radiotherapy SOBP = spread-out Bragg peak UICC = Union for International Cancer Control Abstract: In 1994, carbon-ion radiotherapy was started at the National Institute of Radiological Sciences using the Heavy-Ion Medical Accelerator in Chiba. Between June 1995 and March 2000, two phase I/II dose escalation studies (protocols 9402 and 9703) of hypofractionated carbon-ion radiotherapy for both early-and advance-stage prostate cancer patients had been carried out to establish radiotherapy technique and to determine the optimal radiation dose. To validate the feasibility and efficacy of hypofractionated carbon-ion radiotherapy, a phase II study (9904) was initiated in April 2000 using the shrinking field technique and the recommended dose fractionation (66 gray equivalents in 20 fractions over 5 weeks) obtained from the phase I/II studies, and was successfully completed in October 2003. The data from 175 patients in the phase II study showed the importance of an appropriate use of androgen deprivation therapy according to tumor risk group. Since November 2003, carbon-ion radiotherapy for prostate cancer was approved as "Highly Advanced Medical Technology" from the Ministry of Health, Labor, and Welfare, and since then approximately 1100 patients have received carbon-ion radiotherapy as of July 2011. In this review, we introduce our steps thorough three clinical trials carried out at National Institute of Radiological Sciences, and show the updated data of carbon-ion radiotherapy obtained from approximately 1000 prostate cancer patients. In addition, our recent challenge and future direction will be also described.

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Value and Perspectives of Proton Radiation Therapy for Limited Stage Prostate Cancer

Abstract: Despite relatively short follow-up times it seems justified to conclude that proton beam irradiation of prostate cancer can improve bNED rates by 10% and decrease Grade 2 late effects by more than 10%. There were no Grade 3 and 4 late effects.

Cited by 45 publications

References 27 publications

Computed Tomogram prior to Prostatectomy

Computed Tomogram prior to Prostatectomy

Conformal Proton Radiation Therapy for Pediatric Low-Grade Astrocytomas

Carbon‐ion radiation therapy for prostate cancer

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