Conformal Proton Radiation Therapy for Pediatric Low-Grade Astrocytomas

Hug, Eugen B.; Muenter, Marc W.; Archambeau, John O.; DeVries, Alexander; Liwnicz, Boleslaw H.; Loredo, Lilia N.; Grove, Roger; Slater, Jerry D.

doi:10.1007/s00066-002-0874-2

Cited by 156 publications

(69 citation statements)

References 28 publications

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“…(The dose distribution for a child with medulloblastomas undergoing craniospinal irradiation with protons is shown in Figure 2.) LLU investigators reported a reduction in acute toxicity with the treatment of three children with medulloblastoma treated with craniospinal irradiation using the proton beam technique (Yuh et al, 2004). Loma Linda investigators also evaluated proton beam irradiation in the treatment of paediatric patients with intracranial low-grade astrocytoma (Hug et al, 2002a). Between 1991 and 1997, 27 patients underwent fractionated proton radiation therapy for progression of recurrent low-grade astrocytoma.…”

Section: Paediatric Malignanciesmentioning

confidence: 99%

Proton beam therapy

et al. 2005

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Conventional radiation therapy directs photons (X-rays) and electrons at tumours with the intent of eradicating the neoplastic tissue while preserving adjacent normal tissue. Radiation-induced damage to healthy tissue and second malignancies are always a concern, however, when administering radiation. Proton beam radiotherapy, one form of charged particle therapy, allows for excellent dose distributions, with the added benefit of no exit dose. These characteristics make this form of radiotherapy an excellent choice for the treatment of tumours located next to critical structures such as the spinal cord, eyes, and brain, as well as for paediatric malignancies.

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Section: Paediatric Malignanciesmentioning

confidence: 99%

Proton beam therapy

et al. 2005

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“…In small series, it has been found to be well tolerated; however, it is not widely available to patients and has not proven to be superior to standard techniques. 27,65 Current recommendations state that children younger than 7 years of age should receive chemotherapy as first-line treatment. Children between the ages of 7 and 10 years fit into a gray zone of patients who may or may not warrant radiation therapy, and patients older than 10 years should be treated with [45][46][47][48][49][50] Gy in fractions of 160-200 cGy each.…”

Section: Radiotherapy For Opgsmentioning

confidence: 99%

Optic pathway gliomas: a review

Binning

Liu

Kestle

et al. 2007

FOC

169

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✓Optic pathway gliomas represent approximately 3–5% of childhood intracranial tumors. They usually occur in children during the first decade of life and are seen in 11–30% of patients with neurofibromatosis Type 1 (NF1). Although these tumors are typically low-grade gliomas, the clinical course and natural history are highly variable, making treatment paradigms difficult. Overall, however, they are often indolent tumors that can be observed over time for progression without initial treatment, especially in patients with NF1. Chemotherapy is the first-line treatment for progressive tumors, and radiation therapy is reserved for patients with progressive disease who are older than 5–7 years. Surgery is reserved for large tumors causing mass effect or hydrocephalus and tumors confined to the orbit or unilateral optic nerve.

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“…Hug et al [14] evaluated the safety and efficacy of proton therapy for 27 patients with progressive or recurrent intracranial LGG, treated between 1991 and 1997 at Loma Linda University Medical Center. Fifteen patients had diencephalic tumors, seven had cerebral and cerebellar hemispheres tumors and in five the tumor was located in the brainstem.…”

Section: Low-grade Gliomasmentioning

confidence: 99%

Proton Radiotherapy for Childhood Tumors: an Overview of Early Clinical Results

MacDonald¹

2013

J Nucl Med Radiat Ther

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Radiation therapy (RT) is an important part of a multidisciplinary treatment for many pediatric tumors and has been integral to the improvement in disease control seen over the past few decades. However, long-term survivors experience late morbidity related to RT. Proton radiation therapy is an emerging type of radiotherapy that can mitigate the incidence of acute and late side effects by minimizing the dose of radiation to normal tissues with a significant reduction of integral dose compared with photons. Furthermore, true clinical advantages are now being measured and published in the medical literature, showing both excellent disease control rates and reduction of late effects. The purpose of this review is to summarize the early clinical outcomes after proton radiotherapy in childhood available in the literature.

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Conformal Proton Radiation Therapy for Pediatric Low-Grade Astrocytomas

Cited by 156 publications

References 28 publications

Proton beam therapy

Proton beam therapy

Optic pathway gliomas: a review

Proton Radiotherapy for Childhood Tumors: an Overview of Early Clinical Results

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