Value Addition to Chemical Compounds Through Biotransformation

Dalal, Kiran S.; Pendharkar, Girish B.; Dalal, Dipak S.; Chaudhari, Bhushan L.

doi:10.1007/978-981-16-5214-1_13

Cited by 3 publications

(4 citation statements)

References 171 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Analysis using CLEAN (contrastive learning-enabled enzyme annotation), which predicts enzyme function (Gregoire et al 2023), showed that one NTF-specific OG with the polysaccharide lyase family 8 domain is closely related to Hyl, a bacterial hyaluronate lyase (EC:4.2.2.1). Bacterial Hyl is an important virulence factor employed by Gram-positive bacteria to enhance their infectivity by degrading extracellular hyaluronate and chondroitin sulfate of animal hosts (Patil et al 2023). All NTF species encode two Hyl homologs, except for Dr. stenobrocha (one homolog).…”

Section: Resultsmentioning

confidence: 99%

The Genomes of Nematode-Trapping Fungi Provide Insights into the Origin and Diversification of Fungal Carnivorism

Fan,

Du,

Zhang

et al. 2024

Preprint

View full text Add to dashboard Cite

Nematode-trapping fungi (NTF), most of which belong to a monophyletic lineage in Ascomycota, cannibalize nematodes and other microscopic animals, raising questions regarding the types and mechanisms of genomic changes that enabled carnivorism and adaptation to the carbon-rich and nitrogen-poor environment created by the Permian-Triassic extinction event. Here, we conducted comparative genomic analyses of 21 NTF and 21 non-NTF to address these questions. Carnivorism-associated changes include expanded genes for nematode capture, infection, and consumption (e.g., adhesive proteins, CAP superfamily, eukaryotic aspartyl proteases, and serine-type peptidases). Although the link between secondary metabolite (SM) production and carnivorism remains unclear, we found that the numbers of SM gene clusters among NTF are significantly lower than those among non-NTF. Significantly expanded cellulose degradation gene families (GH5, GH7, AA9, and CBM1) and contracted genes for carbon-nitrogen hydrolases (enzymes that degrade organic nitrogen to ammonia) are likely associated with adaptation to the carbon-rich and nitrogen-poor environment. Through horizontal gene transfer events from bacteria, NTF acquired the Mur gene cluster (participating in synthesizing peptidoglycan of the bacterial cell wall) and Hyl (a virulence factor in animals). Disruption of MurE reduced NTF's ability to attract nematodes, supporting its role in carnivorism. This study provides new insights into how NTF evolved and diversified after the Permian-Triassic mass extinction event.

show abstract

Section: Resultsmentioning

confidence: 99%

The Genomes of Nematode-Trapping Fungi Provide Insights into the Origin and Diversification of Fungal Carnivorism

Fan,

Du,

Zhang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…[87] Incredibly high enantioselectivity was achieved when Lactobacillus paracasei BD101 was utilized as a whole-cell biocatalyst to produce (S)-6-chlorochroman-4ol. [88] To produce an enantiomerically pure product and full conversion, the asymmetric reduction requirements were improved. The optical purity of the (S)-6-chlorochroman-4-ol produced by this approach is the greatest reported in the literature, and this work is the first to demonstrate enantiopure synthesis of (S)-6-chlorochroman-4-ol utilizing a biocatalyst.…”

Section: Organometallic Catalysismentioning

confidence: 99%

“…Using morachalcone and the dienes B1/B2, this enzyme catalyzed the Diels‐Alder reaction to produce (+)‐artonin I and (+)‐dideoxyartonin I, which have enantiomeric excesses of 99 % and greater, respectively [87] . Incredibly high enantioselectivity was achieved when Lactobacillus paracasei BD101 was utilized as a whole‐cell biocatalyst to produce (S)‐6‐chlorochroman‐4‐ol [88] . To produce an enantiomerically pure product and full conversion, the asymmetric reduction requirements were improved.…”

Section: Biocatalysismentioning

confidence: 99%

Enantioselective Synthesis of Flavonoids and Their Diverse Applications in Nutrition, Health, and Medicine: A Mini Review

Qayyum,

Shahid,

Mansoor

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

Enantioselective synthesis, which yields one enantiomer in higher concentration or purity than the other, has transformed the production of flavonoids. Flavonoids, which are found in large quantities in nature and are known to exhibit a diverse array of physiological activities, are an ideal choice for enantioselective synthesis due to the significance of chirality in their therapeutic effects. Enantioselective synthesis is used in the medicinal, nutraceutical, and agrochemical sectors to produce flavonoids, which are useful in the development of novel therapeutics with improved effectiveness and fewer adverse reactions. The ability to obtain specific enantiomers of flavonoids facilitates the elucidation of biochemical strategies and the relationship between structure and activity, thereby providing avenues for tailored drug design and optimization. This review highlights the critical role that enantioselective synthesis plays in achieving the full potential of flavonoids for a variety of therapeutic and non‐therapeutic applications. It also discusses the challenges and prospects of enantioselective syntheses to create relevant classes of flavonoid monomers, emphasizing their applications in the field. The review focused on the synthetic methods for fabricating native flavonoids and their analogs, highlighting the critical role that enantioselective synthesis of flavonoids plays in maximizing their therapeutic potential for enhancing human health and wellbeing.

show abstract

“…In contrast to purified enzymes, whole-cell systems are easily prepared, cost-efficient, and highly tolerant to organic solvents, thus increasing operational stability and facilitating enzyme recovery and recyclability. 46,47 Therefore, we constructed an easily separated biphasic catalytic system based on whole-cell bio-oxidation. First, we constructed five coexpression strains (P12G, P11G, P21G, etc.)…”

Section: Construction and Optimization Of Bio-oxidation For 5kga Prep...mentioning

confidence: 99%

Chemo-enzymatic cascades producing 2,5-furandicarboxylic acid precursors viad-gluconate “barbell oxidation” and dehydration

Chen

Cai

Sha³

et al. 2023

Green Chem.

View full text Add to dashboard Cite

show abstract

Value Addition to Chemical Compounds Through Biotransformation

Cited by 3 publications

References 171 publications

The Genomes of Nematode-Trapping Fungi Provide Insights into the Origin and Diversification of Fungal Carnivorism

The Genomes of Nematode-Trapping Fungi Provide Insights into the Origin and Diversification of Fungal Carnivorism

Enantioselective Synthesis of Flavonoids and Their Diverse Applications in Nutrition, Health, and Medicine: A Mini Review

Chemo-enzymatic cascades producing 2,5-furandicarboxylic acid precursors viad-gluconate “barbell oxidation” and dehydration

Contact Info

Product

Resources

About