Valores de referência para exames laboratoriais de colesterol, hemoglobina glicosilada e creatinina da população adulta brasileira

Szwarcwald, Célia Landmann; Malta, Déborah Carvalho; Pereira, Cimar Azeredo; Figueiredo, André William; Almeida, Wanessa da Silva de; Machado, Ísis Eloah; Bacal, Nydia Strachman; Silva, Alanna Gomes da; Júnior, Jarbas Barbosa da Silva; Rosenfeld, Luiz Gastão

doi:10.1590/1980-549720190002.supl.2

Cited by 11 publications

(6 citation statements)

References 19 publications

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“…In turn, in the case of the LDL variable, it is important to highlight the association with the participants' gender. In Brazil, for example, there is data from comprehensive research that found women to be more vulnerable to higher levels for this marker (28) .…”

Section: At Higher Doses and Intervention Periods Researchersmentioning

confidence: 99%

Effectiveness of ginger in reducing metabolic levels in people with diabetes: a randomized clinical trial

Carvalho

Neto

Araújo

et al. 2020

Rev. Latino-Am. Enfermagem

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Objective: to evaluate the effectiveness of ginge (Zingiber officinale) in reducing blood sugar and lipid levels in people with type 2 diabetes. Method: a randomized and double-blind clinical trial conducted with people with type 2 diabetes in primary care facilities. The study included individuals aged between 20 and 80 years old, using oral antidiabetic drugs and with HbA1c levels between 6.0% and 10%. The participants were paired 1:1, allocated in two distinct groups, and randomized in blocks, based on their HbA1c levels. In the experimental group, the participants used 1.2g of ginger and, in the control group, 1.2g of placebo, daily for 90 days. The primary outcome was a reduction in fasting blood sugar and HbA1c, and the secondary outcome was a reduction in lipids and HOMA-IR. 103 individuals completed the study, 47 in the experimental group and 56 in the control group. Results: the participants in the experimental group showed a greater reduction in the blood glucose and total cholesterol values compared to the control group. Conclusion: the use of ginger can help in the treatment of people with diabetes, and data support the inclusion of this herbal drug in the clinical practice of nurses. RBR-2rt2wy

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Section: At Higher Doses and Intervention Periods Researchersmentioning

confidence: 99%

Effectiveness of ginger in reducing metabolic levels in people with diabetes: a randomized clinical trial

Carvalho

Neto

Araújo

et al. 2020

Rev. Latino-Am. Enfermagem

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“…Since liposomal amphotericin B is the formulation of choice for the treatment and secondary prophylaxis of VL in patients with AIDS and interacts with serum lipoproteins in vitro and in the rabbit model, influencing the drug tissue concentration [11], the hypothesis that human lipids might be involved with liposomal amphotericin B activity against Leishmania was investigated. All measured lipids were low in patients with AIDS and VL, regardless of whether they relapsed [25]. This profile is distinct from those of patients with VL or AIDS, taken separately.…”

Section: Discussionmentioning

confidence: 64%

Low Plasma Lipids are Associated with Relapsing and Lethal Visceral Leishmaniasis in HIV-Infected Patients

Silva,

Uliana,

Yasunaka

et al. 2024

Preprint

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Visceral leishmaniasis (VL) results from infection by the protozoa Leishmania infantum and L. donovani. HIV-coinfected patients may have a relapsing course of VL, even after secondary prophylaxis with amphotericin B. This study investigated whether host factors would explain the relapses. First, susceptibility to amphotericin B of L. infantum isolates was evaluated in vitro. Then, clinical data and the lipid profile of patients with relapsing and non-relapsing VL were assessed. Susceptibility to amphotericin B was similar between the isolates. CD4+ lymphocytes were reduced in both patients in the first episode and with relapsing VL. Still, the strongest blood cell associated with relapses was low total lymphocyte counts. Total plasma cholesterol, high-density lipoprotein, low-density lipoprotein, and, uniquely, triglycerides of the six individuals in the first episode and 23 with relapsing VL were lower in relapsing patients than those in the first episode. Deceased patients had extremely low, low-density lipoprotein. After CD4+ decrease, lymphocyte CD8+ reduction seem to be the final stage of the immunological failure. The lower lipid concentrations appear to be secondary to the depletion of fat stores by inflammation-induced cachexia provoked by the co-occurrence of both diseases, which can finally lead to death.

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“…According to Branco et al ( 17 ), the % of body fat between 28.8 and 35.7 is considered normal in the Brazilian population. ( 19 ) Reference values biochemical tests Szwarcwald et al ( 19 ). –: no reference value.…”

Section: Resultsmentioning

confidence: 99%

Association between the relative abundance of phyla actinobacteria, vitamin C consumption, and DNA methylation of genes linked to immune response pathways

Noronha,

Noma,

Fernandes Ferreira

et al. 2024

Front. Nutr.

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IntroductionThere is an emerging body of evidence that vitamin C consumption can modulate microbiota abundance and can also impact DNA methylation in the host, and this could be a link between diet, microbiota, and immune response. The objective of this study was to evaluate common CpG sites associated with both vitamin C and microbiota phyla abundance.MethodsSix healthy women participated in this cohort study. They were divided into two groups, according to the amount of vitamin C they ingested. Ingestion was evaluated using the 24-h recall method. The Illumina 450 k BeadChip was used to evaluate DNA methylation. Singular value decomposition analyses were used to evaluate the principal components of this dataset. Associations were evaluated using the differentially methylated position function from the Champ package for R Studio.Results and discussionThe group with higher vitamin C (HVC) ingestion also had a higher relative abundance of Actinobacteria. There was a positive correlation between those variables (r = 0.84, p = 0.01). The HVC group also had higher granulocytes, and regarding DNA methylation, there were 207 CpG sites commonly related to vitamin C ingestion and the relative abundance of Actinobacteria. From these sites, there were 13 sites hypomethylated and 103 hypermethylated. The hypomethylated targets involved the respective processes: immune function, glucose homeostasis, and general cellular metabolism. The hypermethylated sites were also enriched in immune function-related processes, and interestingly, more immune responses against pathogens were detected. These findings contribute to understanding the interaction between nutrients, microbiota, DNA methylation, and the immune response.

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Valores de referência para exames laboratoriais de colesterol, hemoglobina glicosilada e creatinina da população adulta brasileira

Cited by 11 publications

References 19 publications

Effectiveness of ginger in reducing metabolic levels in people with diabetes: a randomized clinical trial

Effectiveness of ginger in reducing metabolic levels in people with diabetes: a randomized clinical trial

Low Plasma Lipids are Associated with Relapsing and Lethal Visceral Leishmaniasis in HIV-Infected Patients

Association between the relative abundance of phyla actinobacteria, vitamin C consumption, and DNA methylation of genes linked to immune response pathways

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