“…Among patients undergoing stress echocardiography, McCully et al [19] examined 1,325 patients with no known heart disease and a normal exercise echocardiogram during a mean follow-up of 2 years for a composite endpoint of all-cause mortality and cardiac events. The authors found that none of the traditional CAD risk factors were associated with a worse outcome However in the prior literature assessing the normal SPECT study and positive coronary angiography, those with 0-1 CAD risk factors had an excellent long-term prognosis, those with multiple risk factors had a worse prognosis and must be considered at being at intermediate risk[20][21][22][23][24][25][26]. When taken individually, only diabetes, smoking, and hypertension were associated with an increase in mortality, but family history and a history of hyperlipidemia were not.…”