2008
DOI: 10.1590/s0034-72992008000600007
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Valor prognóstico da correlação imunoistoquímica do Ki-67 e p53 em carcinomas epidermóides da laringe

Abstract: Prognost ic histological factors may contribute to determine the evolution of this neoplasia. Aim: To correlate p53 and Ki-67 immunohistochemical expression with age, histological degree, lymph node involvement and pathological staging in patients with laryngeal epidermoid carcinomas. Methods:We assessed thirty consecutive cases of laryngeal epidermoid carcinomas submitted to immunohistochemistry to check the expression of p53 e Ki-67 antibodies. Results: Mean age was of 56.2 years and the immunoexpression of … Show more

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Cited by 7 publications
(11 citation statements)
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“…In this study, there was a strong direct correlation between the mean tumor volume and tumor malignancy grade, ie, the lesions classified as high grade showed the highest rates of tumor growth when compared with the low-grade ones, showing that morphologically undifferentiated cells are genetically unstable and easily escape from cell cycle control mechanisms, with a tendency to have high cell proliferation rates, in agreement with other studies 16,17 . The Ki-67 immunoreactivity relates to evidence of cell proliferation, so that it is expressed in all cell cycle phases but G0, in which cells are quiescent 18 .…”
Section: Discussionsupporting
confidence: 92%
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“…In this study, there was a strong direct correlation between the mean tumor volume and tumor malignancy grade, ie, the lesions classified as high grade showed the highest rates of tumor growth when compared with the low-grade ones, showing that morphologically undifferentiated cells are genetically unstable and easily escape from cell cycle control mechanisms, with a tendency to have high cell proliferation rates, in agreement with other studies 16,17 . The Ki-67 immunoreactivity relates to evidence of cell proliferation, so that it is expressed in all cell cycle phases but G0, in which cells are quiescent 18 .…”
Section: Discussionsupporting
confidence: 92%
“…However, it is interesting to note that in several studies the Ki-67 presents a tendency to strong direct correlation with the lesion malignancy degree, being valuable as a prognostic predictor 17,18 . The p16 INK4a tumor suppressor gene, encoding the p16 protein, is inactivated by hypermethylation in several types of malignancies, including oral squamous cell carcinoma, constituting a crucial event in the early stages of malignant transformation of the affected tissue.…”
Section: Discussionmentioning
confidence: 99%
“…The sample of subjects enrolled in this study was constituted by male patients from 46 to 71 years of age, mean age of 59.3 years, in agreement with the literature that indicates a higher predominance of male patients (1,3) .…”
Section: Discussionmentioning
confidence: 67%
“…Larynx cancer is considered the most common head and neck malignant neoplasm, mainly occurring in male individuals, with an incidence of 130.000 new cases a year in the world (1) . It's main symptom is dysphonia, once the glottis region is generally more affected, followed by the supraglottis and subglottis regions (2) .…”
Section: Introductionmentioning
confidence: 99%
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