Valor preditivo da mieloperoxidase na identificação de pacientes de alto risco admitidos por dor torácica aguda

Esporcatte, Roberto; Rey, Helena Cramer Veiga; Rangel, Fod; Rocha, Ricardo Mourilhe; Filho, Hugo Tannus Furtado de Mendonça; Dohmann, Hans Fernando Rocha; Filho, Francisco Manes Albanesi

doi:10.1590/s0066-782x2007001800005

Cited by 8 publications

(2 citation statements)

References 26 publications

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“…Previous studies reported circulating concentrations of MPO protein to associate with atherosclerotic plaque instability (cardiovascular event risk), 30, 31 and plaque erosion. 32, 33 However, other studies showed no link between circulating MPO protein and cardiovascular risk.…”

Section: Discussionmentioning

confidence: 99%

Myeloperoxidase activity predicts atherosclerotic plaque disruption and atherothrombosis

Nadel,

Wang,

Saha

et al. 2023

Preprint

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BackgroundUnstable atherosclerotic plaque is characterized by increased myeloperoxidase (MPO) activity. As unstable plaque is vulnerable to disruption and ensuing thrombosis, we examined whether plaque MPO activity predicts atherothrombosis in a pre-clinical model and correlates with ruptured human atheroma.MethodsTo assess if plaque MPO activity predicts atherothrombosis, rabbits were subjected to aortic endothelial denudation, cholesterol feeding,in vivomagnetic resonance imaging (MRI) of MPO activity using MPO-Gd (gadolinium), followed by pharmacological triggering of atherothrombosis, histology, and MPO activity determined by liquid chromatography tandem mass spectrometry (LC-MSMS) by quantifying the MPO-specific product of hydroethidine, 2-chloroethidium. To correlate plaque MPO activity to ruptured human atheroma,ex vivodetermination of MPO activity by MPO-Gd retention in carotid endarterectomy (CEA) specimens was correlated within vivoMRI plaque phenotyping in patients, histology, and MPO activity determined by LC-MSMS.ResultsIn rabbits, pre-triggerin vivoMPO activity, validated by LC-MSMS and histology, was higher in thrombosis-prone than thrombosis-resistant plaques and lesion-free segments (R1 relaxation rate = 2.2 ± 0.4 versus 1.6 ± 0.2 and 1.5 ± 0.2 s-1, respectively, p<0.0001), and it predicted atherothrombosis. In CEA specimens, MPO-Gd retention was greater in histologic and MRI-graded American Heart Association (AHA) type VI than types III, IV and V plaques (ΔR1 relaxation rate from baseline = 48 ± 6 versus 16 ± 7, 17 ± 8 and 23 ± 8%, respectively, p<0.0001). This association was confirmed by comparing AHA grade to MPO activity determined by LC-MSMS (277 ± 338 versus 7 ± 6, 11 ± 12 and 42 ± 39 pmol 2-chloroethidium/mg protein for type VI versus type III-V plaques, respectively, p=0.0008).ConclusionsMPO activity is elevated in thrombosis-prone rabbit and ruptured human atheroma. Non-invasive molecular imaging of MPO activity predicts atherothrombosis, highlighting the potential of arterial MPO activity to detect vulnerable, destabilized atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Myeloperoxidase activity predicts atherosclerotic plaque disruption and atherothrombosis

Nadel,

Wang,

Saha

et al. 2023

Preprint

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“…Menezes Junior et al16 showed that the combined effect of optimized atrial stimulation and atenolol is more effective in controlling recurrent atrial fibrillation. Esporcatte et al17 showed that myeloperoxidase is highly effective in predicting high risk in patients with acute chest pain; Guerzoni et al18 found that the TT genotype of the methyl-N-tetrahydrofolate reductase gene associates with more serious cases of coronary obstruction. while Villacorta et al19 claim that C-reactive protein is an inflammatory marker with prognostic value in patients with decompensated heart failure.…”

Section: Cardiovascularmentioning

confidence: 99%

Recent Trends in Brazilian Medical Research. An Overview

Rocha-e-Silva¹

2009

Clinics

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This article reviews 69 original research articles published in 6 Brazilian Medical Journals recently incorporated into the Institute for Scientific Information Journal of Citation Reports, with a view of making them comprehensively available to the readership of CLINICS within a subject category division. We expect this review to increase the visibility of a wide specter of original Brazilian research which may otherwise remain relatively unseen by the interested readershi

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Cardiovascular Biomarker Assessment Across Glycemic Status

Tang

2015

Glucose Intake and Utilization in Pre-Diabetes and Diabetes

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Valor preditivo da mieloperoxidase na identificação de pacientes de alto risco admitidos por dor torácica aguda

Abstract: In patients with acute chest pain and no ST elevation, high MPO levels upon admission to the hospital are an important tool to predict in-hospital adverse events, with an odds ratio of eight for the diagnosis of AMI.

Cited by 8 publications

References 26 publications

Myeloperoxidase activity predicts atherosclerotic plaque disruption and atherothrombosis

Myeloperoxidase activity predicts atherosclerotic plaque disruption and atherothrombosis

Recent Trends in Brazilian Medical Research. An Overview

Cardiovascular Biomarker Assessment Across Glycemic Status

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