Validity, reliability and prevalence of four ‘clinical content’ subtypes of depression

Sharpley, Christopher F.; Bitsika, Vicki

doi:10.1016/j.bbr.2013.10.032

Cited by 27 publications

(19 citation statements)

References 56 publications

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“…Specifically, dysphoria mood, somatic symptoms, and cognitive symptoms were all moderately influenced by genetic factors (heritability ranged from 33 to 40%), but were less influenced by shared environmental factors. The three genetically influenced depression dimensions in our study were congruent with the three clinical content subtypes of depression (depressed mood, somatic depression, and cognitive depression) proposed by Sharpley and Bitsika (, ). Our findings were also partly in line with Jang et al.…”

Section: Discussionsupporting

confidence: 91%

“…Substantial evidence has supported the existence of subtypes of depression. For example, Sharpley and Bitsika (, ) suggested four clinical content subtypes of depression that supposedly possessed different neurobiological pathways: depressed mood, anhedonic depression, somatic depression, and cognitive depression. Psychometric investigation of depression scales has also supported the multidimensionality of depression.…”

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confidence: 99%

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Etiological heterogeneity of symptom dimensions of adolescent depression

Chen

Zhang

et al. 2014

PsyCh Journal

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The aim was to investigate the underlying factor structure of adolescent depression and etiological heterogeneity in the symptom dimensions of adolescent depression. The sample included 842 pairs of same-sex adolescent twins, among which 613 pairs were monozygotic twins and 229 pairs were dizygotic twins. The ages of the participants ranged from 11 to 17 years (M = 13.64, SD = 1.80). Adolescents' depressive symptoms were assessed using the self-reported Children's Depression Inventory. Exploratory and confirmatory factor analyses were used to explore the factor structure of youth depression and twin genetic analyses were employed to estimate genetic and environmental influences on the derived dimensions. Results showed that adolescent depression encompassed five correlated dimensions: dysphoria mood, somatic symptoms, study and externalizing problems, anhedonia symptoms, and cognitive symptoms. These five symptom dimensions had heterogeneous etiologies: Dysphoria mood, somatic symptoms, and cognitive symptoms were moderately heritable (heritability ranged from 33 to 40%), whereas study and externalizing problems, and anhedonia symptoms were mainly environmentally influenced with minimal genetic basis. Our findings supported the multidimensionality of adolescent depression and the etiological heterogeneity of these symptom dimensions.

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Section: Discussionsupporting

confidence: 91%

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confidence: 99%

Etiological heterogeneity of symptom dimensions of adolescent depression

Chen

Zhang

et al. 2014

PsyCh Journal

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“…By contrast, individual PCa patients' scores on the various symptoms, which comprise GAD and MDD, can be used as particular indicators of the severity of those symptoms, with specific treatment protocols following the patient's profile on those symptoms. In a recent review of MDD symptomatology, four distinct ‘clinical content’ subtypes of MDD were defined and described, and each was shown to have different underlying neurobiological pathways and treatment needs as well as discrete symptoms , and these four subtypes of depression have been shown to differ across PCa patients . Those depression subtypes might therefore form a basis on which to assess and diagnose depression in PCa patients, especially those receiving HT, and to form specific treatment plans on the basis of those diagnoses.…”

Section: Discussionmentioning

confidence: 99%

Differences in major depressive disorder and generalised anxiety disorder symptomatology between prostate cancer patients receiving hormone therapy and those who are not

et al. 2014

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Although these data confirm the association between HT and anxiety/depression, the range of GAD and MDD symptoms influenced is relatively restricted. Moreover, functional ability does not appear to be impaired by HT. These findings clarify the ways in which HT affects PCa patients and suggests that a simple total scale score for anxiety and depression may not be as helpful in designing treatment as consideration of the symptomatic profiles of PCa patients receiving HT.

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“…MDD is a heterogeneous disorder. However, due to our relatively small sample size, we could not evaluate differences among various MDD subtypes that described in the previous reports 10–14 .…”

Section: Discussionmentioning

confidence: 82%

“…For example, Parker has proposed that depression may have various forms 10 , and Ostergaard and colleagues 11 pointed out that MDD may present in 1497 different combinations of the symptoms that are used to define it 12 . Recent data which demonstrate the different neurobiological underpinnings, pathways and required treatments for at least four different “subtypes” of depression based upon separation of MDD symptoms into distinct categories according to symptom coherence 13, 14 . In other words, MDD is a heterogeneous disorder, which origins from various pathophysiology.…”

Section: Introductionmentioning

confidence: 99%

Voxel-based morphometric brain comparison between healthy subjects and major depressive disorder patients in Japanese with the s/s genotype of 5-HTTLPR

Igata

Kakeda

Watanabe

et al. 2017

Sci Rep

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Individuals with s/s genotype of serotonin transporter gene-linked promotor region (5-HTTLPR), which appear with a high frequency in Japanese, exhibit more diagnosable depression in relation to stressful life events than those with the s/l or l/l genotype. We prospectively investigated the brain volume changes in first-episode and medication naïve major depression disorder patients (MDD) with the s/s genotype in Japanese. We assessed the differences between 27 MDD with the s/s genotype and 44 healthy subjects (HS) with the same genotype using a whole-brain voxel-by-voxel statistical analysis of MRI. Gray matter volume in a brain region with significant clusters obtained via voxel-based morphometry analysis were measured and, as an exploratory analysis, evaluated for relationships to the subcategory scores (core, sleep, activity, psychic, somatic anxiety, delusion) of the Hamilton Depression Rating Scale (HAM-D) and the Social Readjustment Rating Scale (SRRS). The brain volume in the left insula lobe was significantly smaller in the MDD than in the HS. The left insula lobe volume correlated negatively with the “psychic” score of HAM-D and the SRRS. In a Japanese population with the s/s genotype, we found an atrophy of the insula in the MDD, which might be associated with “psychic” symptom and stress events.

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Validity, reliability and prevalence of four ‘clinical content’ subtypes of depression

Cited by 27 publications

References 56 publications

Etiological heterogeneity of symptom dimensions of adolescent depression

Etiological heterogeneity of symptom dimensions of adolescent depression

Differences in major depressive disorder and generalised anxiety disorder symptomatology between prostate cancer patients receiving hormone therapy and those who are not

Voxel-based morphometric brain comparison between healthy subjects and major depressive disorder patients in Japanese with the s/s genotype of 5-HTTLPR

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