Validity of the K-10 in detecting DSM-IV-defined depression and anxiety disorders among HIV-infected individuals

Abstract

It has been suggested that an HIV diagnosis may increase the likelihood of mental disorders among infected individuals and that the progression of HIV may be hastened by mental disorders like anxiety and depression. Therefore, a brief screening measure, with good sensitivity/specificity for psychiatric diagnoses that could be given to HIV-infected individuals would be useful. We assessed the validity of the K-10, using the MINI International Neuropsychiatric Interview as the gold standard, in a sample of 429 HIV-infected adults enrolled in HIV care and treatment services near Cape Town, South Africa. There was significant agreement between the K-10 and the MINI-defined depressive and anxiety disorders. A receiver operating characteristic (ROC) curve analysis indicated that the K-10 showed agreeable sensitivity and specificity in detecting depression (area under the ROC curve, 0.77), generalized anxiety disorder (0.78), and posttraumatic stress disorder (PTSD) (0.77). The K-10 may be a useful screening measure for detecting mood and anxiety disorders, including PTSD, in patients with HIV/AIDS.

Effect of Caregivers' Depression and Alcohol Use on Child Antiretroviral Adherence in South Africa

“…29 It is possible that this high prevalence was due to the cross-cultural use of the BDI1, however this tool has previously been validated in South Africa, and studies utilizing other tools have had similar findings. 25,[27][28][29][30][31][32][33] In contrast, reported problem drinking as measured by AUDIT was rare.…”

Validity of the patient health questionnaire-9 to screen for depression in a high-HIV burden primary healthcare clinic in Johannesburg, South Africa

“…A limited number of validation studies of depression screening tools have been conducted against diagnostic reference standards in sub-Saharan African settings, but these studies have varied in their choice of context, screening tool, and diagnostic measure, making the results difficult to apply to a PHC context. (Andersen et al, 2011, Akena et al, 2012a, Akena et al, 2012b, Pence et al, 2012, Chishinga et al, 2011, Monahan et al, 2009, Myer et al, 2008, Nakimuli-Mpungu et al, 2012b, Spies et al, 2009, Adewuya et al, 2006, Akena et al, 2013). In particular, the populations included in these studies, such as university students, household survey participants, pregnant or postnatal women, or HIV-infected patients, are not easily generalizable to a PHC population.…”

Mental Health Services in South Africa: Taking stock

“…19 Several studies indicate the ongoing need for culturally acceptable and evidence-based psychological treatment services for CMDs. 10 High rates of maternal depression 22,23 and depression in PLWHAs in South Africa [24][25][26] require that HIV and maternal health services integrate mental health into their care. There is also a need for referral pathways for trauma, which is highly predictive of CMDs.…”