Validity of the finger tapping test in Parkinson’s disease, elderly and young healthy subjects: Is there a role for central fatigue?

Arias, Pablo; Robles-García, Verónica; Espinosa, Nelson; Corral, Yoanna; Cudeiro, Javier

doi:10.1016/j.clinph.2012.04.001

Cited by 56 publications

(69 citation statements)

References 36 publications

(44 reference statements)

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“…Similar abnormalities have been reported in individuals with fatigue related to multiple sclerosis [3,9], Parkinson’s disease [10,11], and cancer [12,13]. These brain regions are known to contribute to cognitive functioning, including working memory [14–19].…”

Section: Introductionsupporting

confidence: 54%

Task related cerebral blood flow changes of patients with chronic fatigue syndrome: an arterial spin labeling study

Staud

Boissoneault

Craggs

et al. 2018

Fatigue: Biomedicine, Health & Behavior

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Purpose One hallmark of chronic fatigue syndrome (ME/CFS) is task related worsening of fatigue. Global brain hypoperfusion, abnormal regional activation, and altered functional connectivity of brain areas associated with cognition and memory have been reported but remain controversial. Methods We enrolled 17 female participants fulfilling the CDC Criteria for ME/CFS and 16 matched healthy controls (HC). Using a 3T-Phillips Achieva MRI-scanner, pseudo-continuous arterial spin-labeling (pCASL), was used to study the dynamics of regional cerebral blood flow (rCBF) and their relationship to mental fatigue in ME/CFS patients and HC during a demanding cognitive task, i.e. modified Paced-Auditory-Serial-Addition-Testing (PASAT). Results ME/CFS subjects reported more fatigue than HC at baseline (p < .01). Global brain perfusion of ME/CFS and HC subjects was similar at rest. The PASAT resulted in significantly increased fatigue in ME/CFS participants and HC. Although not different between groups, overall CBF significantly increased over the first 3 min of the PASAT and then decreased thereafter. Regional CBF (rCBF) changes were significantly different between groups during the post-task recovery period. Whereas improvement of fatigue of ME/CFS subjects was associated with decreased rCBF in both superior temporal gyri (STG), precuneus, and fusiform gyrus, it was associated with increased rCBF in the same areas in HC. Conclusions Our results suggest that ME/CFS is associated with normal global CBF at rest and during a strenuous task (PASAT); however rCBF of several brain regions associated with memory, goal-oriented attention, and visual function was differentially associated with recovery from fatigue in ME/CFS patients and HC.

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Section: Introductionsupporting

confidence: 54%

Task related cerebral blood flow changes of patients with chronic fatigue syndrome: an arterial spin labeling study

Staud

Boissoneault

Craggs

et al. 2018

Fatigue: Biomedicine, Health & Behavior

View full text Add to dashboard Cite

show abstract

“…This common psychomotor test was used to detect alterations in rhythmic patterns due to aging and cognitive disorders (Arias, Robles-García, Espinosa, Corral, & Cudeiro, 2012; Reitan & Wolfson, 2008). Participants were asked to tap their index finger quickly using a digital tapping device for ten seconds.…”

Section: Methodsmentioning

confidence: 99%

Feasibility of a Home-Based Speed of Processing Training Program in Middle-Aged and Older Adults With HIV

Cody

Fazeli

Vance

2015

Journal of Neuroscience Nursing

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There has been much optimism over the positive impact of cART on life expectancy for people with HIV; however, those aging with HIV fear potential day-to-day challenges associated with the development of cognitive deficits. The presence of cognitive deficits has generated major safety concerns as it has been shown to impact driving, mobility, and employment. Given the efficacy of a computerized speed of processing training program administered in the laboratory to older adults and adults with HIV, this study was designed to determine the feasibility of a home-based speed of processing training program in improving cognitive function in middle-aged and older adults with HIV. In this within-subjects pre-post experimental design, twenty middle-aged and older adults (i.e., age 40+) with HIV were administered a brief neuropsychological assessment to gauge their baseline cognitive function before participating in a 10-hour home-based computerized cognitive remediation training program. In addition to self-reported cognitive gains, a six-week posttest indicated significant improvements on the Useful Field of View (UFOV®), a measure of speed of processing and possible transfer to the Timed Instrumental Activities of Daily Living test, a measure of everyday functioning. These findings show that speed of processing training can successfully improve cognitive function in this vulnerable population even when administered in remote settings such as the privacy of one's home.

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“…Movement variability is also critical for responding to permutations in the environment and producing on-line corrections [44,50,51]. On the other hand, pathologically increased movement variability has been characterized in many neurologic conditions, including Parkinson disease [52][53][54][55][56], stroke [39,57], dystonia [41,58], developmental coordination disorder [59,60], and cerebral palsy [61,62], to name a few.…”

Section: Introductionmentioning

confidence: 99%

Methods for Measuring Swallowing Pressure Variability Using High-Resolution Manometry

Jones

Meisner

Broadfoot

et al. 2018

Front. Appl. Math. Stat.

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Any movement performed repeatedly will be executed with inter-trial variability. Oropharyngeal swallowing is a complex sensorimotor action, and swallow-to-swallow variability can have consequences that impact swallowing safety. Our aim was to determine an appropriate method to measure swallowing pressure waveform variability. An ideal variability metric must be sensitive to known deviations in waveform amplitude, duration, and overall shape, without being biased by waveforms that have both positive and sub-atmospheric pressure profiles. Through systematic analysis of model waveforms, we found a coefficient of variability (CV) parameter on waveforms adjusted such that the overall mean was 0 to be best suited for swallowing pressure variability analysis. We then investigated pharyngeal swallowing pressure variability using high-resolution manometry data from healthy individuals to assess impacts of waveform alignment, pharyngeal region, and number of swallows investigated. The alignment that resulted in the lowest overall swallowing pressure variability was when the superior-most sensor in the upper esophageal sphincter (UES) reached half its maximum pressure. Pressures in the tongue base region of the pharynx were least variable and pressures in the hypopharynx region were most variable. Sets of 3-10 consecutive swallows had no overall difference in variability, but sets of two swallows resulted in significantly less variability than the other dataset sizes. This study identified variability in swallowing pressure waveform shape throughout the pharynx in healthy adults; we discuss implications for swallowing motor control.

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Validity of the finger tapping test in Parkinson’s disease, elderly and young healthy subjects: Is there a role for central fatigue?

Abstract: COMFORT mode is recommended in protocols including the FT for evaluating rhythm formation.

Cited by 56 publications

References 36 publications

Task related cerebral blood flow changes of patients with chronic fatigue syndrome: an arterial spin labeling study

Task related cerebral blood flow changes of patients with chronic fatigue syndrome: an arterial spin labeling study

Feasibility of a Home-Based Speed of Processing Training Program in Middle-Aged and Older Adults With HIV

Methods for Measuring Swallowing Pressure Variability Using High-Resolution Manometry

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