Task related cerebral blood flow changes of patients with chronic fatigue syndrome: an arterial spin labeling study

Staud, Roland; Boissoneault, Jeff; Craggs, Jason G.; Lai, Song

doi:10.1080/21641846.2018.1453919

Cited by 20 publications

(35 citation statements)

References 53 publications

(77 reference statements)

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“…Three of the papers used the more stringent CCC criteria to classify ME/CFS patients [15,29,42]. The remaining five research papers used either of the two aforementioned criteria [11,13,20,33,62]. No papers utilised the IOM diagnostic criteria.…”

Section: Participant and Study Characteristicsmentioning

confidence: 99%

“…There were four different neuroimaging techniques used to assess neural changes in ME/ CFS compared with HCs. Out of the 55 studies: 16 studies utilised MRI [11,[13][14][15]20,[31][32][33][34][35][36]43,53,58,62,63], 17 used functional MRI (fMRI) [16,18,[21][22][23][24]26,34,[40][41][42][43]45,49,[49][50][51], five used PET scans [17,25,28,30,44] and 11 used EEG [12,27,29,38,39,[46][47][48]54,55]. The remaining studies used magnetic resonance spectrometry (MRS) [19,…”

Section: Participant and Study Characteristicsmentioning

confidence: 99%

“…Of the included studies, six investigated changes in cerebral blood flow (CBF) in ME/CFS patients compared with HCs [20,21,49,51,62]. Two of the studies reported significantly lower CBF in ME/CFS patients compared with HC [19,62].…”

Section: Literature Reporting Changes In Cerebral Blood Flowmentioning

confidence: 99%

“…Another study showed that there were significantly higher CBF levels when provided with a Paced Auditory Serial Addition Test (PASAT) cognitive task, this then decreased after three minutes. ME/CFS patients had significantly lower rCBF in superior temporal gyri (STG), precuneus and fusiform gyrus during recovery compared to HCs [20]. A single-photon emission computed tomography (SPECT) twin study found that there were no significant differences in rCBF values between a healthy twin and a twin discordant for ME/CFS [21].…”

Section: Literature Reporting Changes In Cerebral Blood Flowmentioning

confidence: 99%

“…Using ASL reported higher fatigue levels in both ME/CFS patients and HCs using PASAT which was accompanied by increased CBF which then progressively decreased after three minutes. During recovery, when compared with HCs, ME/CFS patients exhibited a significant decrease in rCBF in the superior temporal gyri (STG), precuneus and fusiform gyrus [20]. Another study reported a significant increase in the activation of occipito-parietal cortex, posterior cingulate gyrus and para-hippocampal gyrus in ME/CFS patients compared with HCs following being subjected to a fatigue inducing task [23].…”

Section: Literature Reporting Changes In Cognitive Functionmentioning

confidence: 99%

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A systematic review of neurological impairments in myalgic encephalomyelitis/ chronic fatigue syndrome using neuroimaging techniques

et al. 2020

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Background Myalgic encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) is a multi-system illness characterised by a diverse range of debilitating symptoms including autonomic and cognitive dysfunction. The pathomechanism remains elusive, however, neurological and cognitive aberrations are consistently described. This systematic review is the first to collect and appraise the literature related to the structural and functional neurological changes in ME/ CFS patients as measured by neuroimaging techniques and to investigate how these changes may influence onset, symptom presentation and severity of the illness. Methods A systematic search of databases Pubmed, Embase, MEDLINE (via EBSCOhost) and Web of Science (via Clarivate Analytics) was performed for articles dating between December 1994 and August 2019. Included publications report on neurological differences in ME/CFS patients compared with healthy controls identified using neuroimaging techniques such as magnetic resonance imaging, positron emission tomography and electroencephalography. Article selection was further refined based on specific inclusion and exclusion criteria. A quality assessment of included publications was completed using the Joanna Briggs Institute checklist. Results A total of 55 studies were included in this review. All papers assessed neurological or cognitive differences in adult ME/CFS patients compared with healthy controls using neuroimaging techniques. The outcomes from the articles include changes in gray and white matter volumes, cerebral blood flow, brain structure, sleep, EEG activity, functional connectivity

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Section: Participant and Study Characteristicsmentioning

confidence: 99%

Section: Participant and Study Characteristicsmentioning

confidence: 99%

Section: Literature Reporting Changes In Cerebral Blood Flowmentioning

confidence: 99%

Section: Literature Reporting Changes In Cerebral Blood Flowmentioning

confidence: 99%

Section: Literature Reporting Changes In Cognitive Functionmentioning

confidence: 99%

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A systematic review of neurological impairments in myalgic encephalomyelitis/ chronic fatigue syndrome using neuroimaging techniques

et al. 2020

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Peripheral endothelial dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome

et al. 2020

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Aims Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex multisystem disease. Evidence for disturbed vascular regulation comes from various studies showing cerebral hypoperfusion and orthostatic intolerance. The peripheral endothelial dysfunction (ED) has not been sufficiently investigated in patients with ME/CFS. The aim of the present study was to examine peripheral endothelial function in patients with ME/CFS. Methods and results Thirty-five patients [median age 40 (range 18-70) years, mean body mass index 23.8 ± 4.2 kg/m 2 , 31% male] with ME/CFS were studied for peripheral endothelial function assessed by peripheral arterial tonometry (EndoPAT2000). Clinical diagnosis of ME/CFS was based on Canadian Criteria. Nine of these patients with elevated antibodies against β2-adrenergic receptor underwent immunoadsorption, and endothelial function was measured at baseline and 3, 6, and 12 months follow-up. ED was defined by reactive hyperaemia index ≤1.81. Twenty healthy subjects of similar age and body mass index were used as a control group. Peripheral ED was found in 18 of 35 patients (51%) with ME/CFS and in 4 healthy subjects (20%, P < 0.05). Patients with ED, in contrast to patients with normal endothelial function, reported more severe disease according to Bell score (31 ± 12 vs. 40 ± 16, P = 0.04), as well as more severe fatigue-related symptoms (8.62 ± 0.87 vs. 7.75 ± 1.40, P = 0.04) including a higher demand for breaks [9.0 (interquartile range 7.0-10.0) vs. 7.5 (interquartile range 6.0-9.25), P = 0.04]. Peripheral ED showed correlations with more severe immune-associated symptoms (r = À0.41, P = 0.026), such as sore throat (r = À0.38, P = 0.038) and painful lymph nodes (r = À0.37, P = 0.042), as well as more severe disease according to Bell score (r = 0.41, P = 0.008) and symptom score (r = À0.59, P = 0.005). There were no differences between the patient group with ED and the patient group with normal endothelial function regarding demographic, metabolic, and laboratory parameters. Further, there was no difference in soluble vascular cell adhesion molecule and soluble intercellular adhesion molecule levels. At baseline, peripheral ED was observed in six patients who underwent immunoadsorption. After 12 months, endothelial function had improved in five of these six patients (reactive hyperaemia index 1.58 ± 0.15 vs. 2.02 ± 0.46, P = 0.06). Conclusions Peripheral ED is frequent in patients with ME/CFS and associated with disease severity and severity of immune symptoms. As ED is a risk factor for cardiovascular disease, it is important to elucidate if peripheral ED is associated with increased cardiovascular morbidity and mortality in ME/CFS.

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Hypothalamus volumes in adolescent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): impact of self-reported fatigue and illness duration

et al. 2023

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Adolescent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex illness of unknown aetiology. Emerging theories suggest ME/CFS may reflect a progressive, aberrant state of homeostasis caused by disturbances within the hypothalamus, yet few studies have investigated this using magnetic resonance imaging in adolescents with ME/CFS. We conducted a volumetric analysis to investigate whether whole and regional hypothalamus volumes in adolescents with ME/CFS differed compared to healthy controls, and whether these volumes were associated with fatigue severity and illness duration. 48 adolescents (25 ME/CFS, 23 controls) were recruited. Lateralised whole and regional hypothalamus volumes, including the anterior–superior, superior tubular, posterior, anterior-inferior and inferior tubular subregions, were calculated from T1-weighted images. When controlling for age, sex and intracranial volume, Bayesian linear regression models revealed no evidence for differences in hypothalamus volumes between groups. However, in the ME/CFS group, a weak linear relationship between increased right anterior–superior volumes and fatigue severity was identified, which was absent in controls. In addition, Bayesian quantile regression revealed a likely-positive association between illness duration and right superior tubular volumes in the ME/CFS group. While these findings suggest overall comparability in regional and whole hypothalamus volumes between adolescents with ME/CFS and controls, preliminary evidence was identified to suggest greater fatigue severity and longer illness duration were associated with greater right anterior–superior and superior-tubular volumes, respectively. These regions contain the anterior and superior divisions of the paraventricular nucleus, involved in the neuroendocrine response to stress, suggesting involvement in ME/CFS pathophysiology. However, replication in a larger, longitudinal cohort is required.

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Task related cerebral blood flow changes of patients with chronic fatigue syndrome: an arterial spin labeling study

Cited by 20 publications

References 53 publications

A systematic review of neurological impairments in myalgic encephalomyelitis/ chronic fatigue syndrome using neuroimaging techniques

A systematic review of neurological impairments in myalgic encephalomyelitis/ chronic fatigue syndrome using neuroimaging techniques

Peripheral endothelial dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome

Hypothalamus volumes in adolescent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): impact of self-reported fatigue and illness duration

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