Validity of retinal oxygen saturation analysis: Hyperspectral imaging in visible wavelength with fundus camera and liquid crystal wavelength tunable filter

Hirohara, Yoko; Okawa, Yoshihiro; Mihashi, Toshifumi; Yamaguchi, Tatsuo; Nakazawa, Naoki; Tsuruga, Y.; Aoki, Hiroyuki; Maeda, Naoyuki; Uchida, Ichirō; Fujikado, Takashi

doi:10.1007/bf02919416

Cited by 27 publications

(28 citation statements)

References 7 publications

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“…This can be overcome by using light at 410–430 nm where the amount of light absorbed is up to 10 times greater than in the green or near‐infrared region. For larger vessels in retinal images using 500 nm light typical intensity measurements have a standard deviation of 1–5% . Measurements on individual RBC using shorter wavelength 420 nm light have a typical standard deviation on individual measurements below 5% which is very similar to the 3–5% in the present study .…”

Section: Discussionsupporting

confidence: 83%

In Vivo Capillary Loop Hemoglobin Spectroscopy in Labial, Sublingual, and Periodontal Tissues

Townsend¹,

D’Aiuto

Deanfield³

2015

Microcirculation

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Section: Discussionsupporting

confidence: 83%

In Vivo Capillary Loop Hemoglobin Spectroscopy in Labial, Sublingual, and Periodontal Tissues

Townsend¹,

D’Aiuto

Deanfield³

2015

Microcirculation

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“…Recently, LCTF-based systems have received attention in various medical application [14,15,16]. Rapid nonmechanical filter adjustment makes LCTF best suited technology for clinical development, optical imaging and characterization of biological composition tissues [17,18,2].…”

Section: A Spectral Imaging In Medical Applicationsmentioning

confidence: 99%

A Portable System for On-Site Medical Spectral Imaging: Pre-Clinical Development and Early Evaluation

Bartczak

Iso-Mustajärvi

Vrzáková

et al. 2018

2018 IEEE 31st International Symposium on Computer-Based Medical Systems (CBMS)

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Imaging is an integral part of most operating room procedures and is used on a daily basis in the operating theater. Near real-time imaging during surgical procedures can significantly enhance the procedures by providing information about the anatomy and pathological conditions. So far, customizable spectral-imaging systems were only rarely investigated, developed and even less often installed in operational settings, especially microsurgery. In this paper we describe a design of portable imaging system for high throughput spectral characterization of ex vivo samples. The setup presented in this work was used for non-invasive collection of spectral signatures from a set of biological tissues.

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“…Spectral imaging is also potentially a useful tool for making reliable measurements of oxygen saturation in the human ocular fundus; however, a deeper understanding of light propagation from the illumination source through the various layers of the retina and to the detector is needed to enable these measurements to be made accurately. 7 Measured retinal-vessel oxygenation is affected by various parameters that are in general not accurately known such as hematocrit, retinal vessel profile and dimension (since the optical magnification is not well known), and the concentration and location of a range of retinal chromophores, in particular macular pigment and melanin. The recording of spectral retinal images at multiple wavelengths offers enhanced prospects for accurate oximetry in this relatively poorly characterized environment.…”

Section: Introductionmentioning

confidence: 99%

Light path-length distributions within the retina

et al. 2014

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Abstract. A Monte Carlo simulation of light propagation through the retina has been developed to understand the path-length distributions within the retinal vessel. For full-field illumination, the path-length distribution within the vessel comprises directly backscattered light and light that has passed once or twice through the vessel. The origins of these light path-length distributions can be better understood by investigating different combinations of single-point illumination and detection positions. Perhaps the most significant observation is that illumination at the edges of the vessel, rather than over the whole field of view, and detection directly above the vessel capture only the light that has taken a single pass through the vessel. This path-length distribution is tightly constrained around the diameter of the vessel and can potentially provide enhancements for oxygen saturation imaging. The method could be practically implemented using an offset-pinhole confocal imaging system or structured light illumination.

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Validity of retinal oxygen saturation analysis: Hyperspectral imaging in visible wavelength with fundus camera and liquid crystal wavelength tunable filter

Cited by 27 publications

References 7 publications

In Vivo Capillary Loop Hemoglobin Spectroscopy in Labial, Sublingual, and Periodontal Tissues

In Vivo Capillary Loop Hemoglobin Spectroscopy in Labial, Sublingual, and Periodontal Tissues

A Portable System for On-Site Medical Spectral Imaging: Pre-Clinical Development and Early Evaluation

Light path-length distributions within the retina

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