Validity of Point-of-Care Testing with Mission Plus Hemoglobin in Detecting Anemia

Ahmad, Noor Ani; Awaluddin, S. Maria; Samad, Rahama; Kassim, Noraida Mohd; Yusoff, Muslimah Mohd; Razak, Mohd Aznuddin Abdul; Chan, Ying Ying; Sahril, Norhafizah

doi:10.21103/article5(2)_mme1

Cited by 33 publications

(10 citation statements)

References 11 publications

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“…Anaemia was defined as Hb level lower than 11.0 g/dl (Hb < 11.0 g/dl) in pregnant women [2] and Hb level lower than 10.0 g/dl in postpartum mothers (Hb < 10.0 g/dl) [3]. Capillary blood sampling from the finger was used because it provides a reliable and suitable alternative for sampling blood in the clinical and field settings [22][23][24].…”

Section: Methodsmentioning

confidence: 99%

Prevalence and associated risk factors of anaemia among women attending antenatal and post-natal clinics at a public health facility in Ghana

et al. 2019

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Background: Anaemia among pregnant women and post-partum mothers is a public health challenge in Ghana, especially in the Volta Region. While literature abounds on anaemia among pregnant women, the same cannot be said for anaemia among post-partum mothers in the region. This study, therefore, examined the prevalence and associated risk factors of anaemia among women attending antenatal care and post-natal care. Methods: This descriptive cross-sectional survey recruited 409 pregnant women and 194 post-natal mothers attending antenatal and post-natal care, at the Hohoe Municipal Hospital. Background characteristics were collected using a semistructured questionnaire, blood samples were analysed for the presence of anaemia and malaria parasitaemia and folders were reviewed for estimated blood loss. Results: We found the prevalence of anaemia among pregnant women and post-partum mothers to be 33 and 16% respectively. Higher malaria parasitaemia (2%) was found in pregnant women compared with postpartum mothers (1%). We found that 4% of post-partum mothers had abnormal blood loss (301mls-500mls) whereas 5% of them had postpartum haemorrhage (>500mls) during child birth. A univariate logistics regression of anaemia status on some risk factors in pregnant women showed no significant association between anaemia and any of the risk factors. Among post-partum mothers, only mothers' age was statistically significant in the univariate analysis [COR = 0.27 (95% CI:0.103, 0.72);0.008]. Mothers aged 20-29 were 73% less likely to be anaemic. Conclusion: The prevalence of anaemia among pregnant women found in this study points to a situation of moderate public health problem according to WHO cutoff values for the public health significance of anaemia. Strategies should therefore be put in place to encourage thorough health education and promotion programmes among both pregnant and post-partum women.

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Section: Methodsmentioning

confidence: 99%

Prevalence and associated risk factors of anaemia among women attending antenatal and post-natal clinics at a public health facility in Ghana

et al. 2019

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“…Given these challenges, the development and implementation of inexpensive and accurate point‐of‐care assays are urgently needed in limited‐resource settings in order to rapidly, easily, and inexpensively diagnose life‐threatening conditions such as severe anemia. There have been several novel, inexpensive assays for the diagnosis of anemia recently developed , including the one described here, but none has become widely available in resource‐poor locations where severe anemia is prevalent and where low‐cost POC technology would have the highest impact. Although the tremendous global burden of anemia has been recently documented and described through the Global Burden of Diseases Study , the political and philanthropic recognition of non‐infectious causes of anemia (primarily inherited hemoglobinopathies and iron deficiency) remains low.…”

Section: Discussionmentioning

confidence: 99%

“…Overall, the Hemocue system is rapid, easy‐to‐use, and accurate means to measure hemoglobin, but the cost of the disposable cuvettes, although less expensive than more advanced hematology analyzers, is likely still too expensive for widespread use in the clinical setting of limited‐resource‐poor countries. The currently described assay is one among several other recently developed POC assays that have the potential to improve the diagnosis of severe anemia in resource‐limited settings where anemia is common and life‐threatening.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the recognition by WHO that a low‐cost, inexpensive, and reliable measure of hemoglobin is urgently needed, such an assay has yet to reach the countries where the need is the greatest . Recently, with significant advancements in biotechnology and bioengineering, several point‐of‐care (POC) assays for the measurement of hemoglobin concentration have been developed , but none have become widely utilized in resource‐poor settings where they are most urgently needed.…”

Section: Introductionmentioning

confidence: 99%

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An accurate and inexpensive color‐based assay for detecting severe anemia in a limited‐resource setting

et al. 2015

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Severe anemia is an important cause of morbidity and mortality among children in resource-poor settings, but laboratory diagnostics are often limited in these locations. To address this need, we developed a simple, inexpensive, and color-based point-of-care (POC) assay to detect severe anemia. The purpose of this study was to evaluate the accuracy of this novel POC assay to detect moderate and severe anemia in a limited-resource setting. The study was a cross-sectional study conducted on children with sickle cell anemia in Luanda, Angola. The hemoglobin concentrations obtained by the POC assay were compared to reference values measured by a calibrated automated hematology analyzer. A total of 86 samples were analyzed (mean hemoglobin concentration 6.6 g/dL). There was a strong correlation between the hemoglobin concentrations obtained by the POC assay and reference values obtained from an automated hematology analyzer (r=0.88, P<0.0001). The POC assay demonstrated excellent reproducibility (r=0.93, P<0.0001) and the reagents appeared to be durable in a tropical setting (r=0.93, P<0.0001). For the detection of severe anemia that may require blood transfusion (hemoglobin <5 g/dL), the POC assay had sensitivity of 88.9% and specificity of 98.7%. These data demonstrate that an inexpensive (<$0.25 USD) POC assay accurately estimates low hemoglobin concentrations and has the potential to become a transformational diagnostic tool for severe anemia in limited-resource settings.

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“…The examination was done by taking capillary blood samples which would be placed on a strip that would read hemoglobin levels automatically. The validity of hemoglobin measurements using this tool was 0.909 for measurements through capillary blood samples (Ahmad et al, 2015), while the reliability value for the Hb meter was 0.80 (Pawlowski et al, 2015). Pregnant women with hemoglobin levels of less than 11 g/dl were categorized as anemic (Silverberg, 2012).…”

Section: Methodsmentioning

confidence: 99%

The Implementation of Iron Supplementation and Antenatal Counseling for Iron Deficiency Anemia in Pregnancy

et al. 2019

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Anemia is one of the contributing conditions that cause maternal mortality in Indonesia. The Indonesian Ministry of Health try to reduce it through an antenatal care program conducted at public health center, with several indicators including iron supplementation and antenatal counseling. This study was conducted to find out the relationship between iron supplementation and antenatal counseling to iron deficiency anemia during pregnancy. This study was a correlative study with cross sectional approach carried out in February until June 2018. The population was 1,285 pregnant women with 102 samples recruited using purposive sampling technique. Blood hemoglobin levels were examined using Hb Meter. Data collection were carried out through guided interviews. Data analysis was done using Chi-Square Test. The implementation of iron supplementation and antenatal counseling was implemented comprehensively (51.0%; 64.7% respectively). This study showed that there was a relationship between iron supplementation and iron deficiency anemia (0.000) and there was no relationship between antenatal counseling and iron deficiency anemia (0.249). It is recommended to all antenatal providers to improve the service provided, especially the iron supplementation that accompanied by giving information through antenatal counseling, so the high maternal mortality rates due to iron deficiency anemia can be treated immediately.

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Validity of Point-of-Care Testing with Mission Plus Hemoglobin in Detecting Anemia

Cited by 33 publications

References 11 publications

Prevalence and associated risk factors of anaemia among women attending antenatal and post-natal clinics at a public health facility in Ghana

Prevalence and associated risk factors of anaemia among women attending antenatal and post-natal clinics at a public health facility in Ghana

An accurate and inexpensive color‐based assay for detecting severe anemia in a limited‐resource setting

The Implementation of Iron Supplementation and Antenatal Counseling for Iron Deficiency Anemia in Pregnancy

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