Validity of Midday Total Testosterone Levels in Older Men with Erectile Dysfunction

Welliver, Robert C.; Wiser, Herbert J.; Brannigan, Robert E.; Feia, Kendall; Monga, Manoj; Köhler, Tobias

doi:10.1016/j.juro.2014.01.085

Cited by 17 publications

(4 citation statements)

References 19 publications

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“…Fasted blood samples were collected on days 0, 14, 42, and 56 between 06:00 h and 09:00 h to limit the potential confounding effects of circadian rhythm on total testosterone in young men [17]. Blood samples were analysed for total testosterone, follicle-stimulating hormone, estradiol, sex hormone-binding globulin, luteinising hormone, insulin, cortisol, and prostate-specific antigen (Siemens Immulite 2000, Llanberis, UK).…”

Section: Methodsmentioning

confidence: 99%

Effects of testosterone supplementation on body composition and lower-body muscle function during severe exercise- and diet-induced energy deficit: A proof-of-concept, single centre, randomised, double-blind, controlled trial

et al. 2019

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Background Severe energy deficits during military operations, produced by significant increases in exercise and limited dietary intake, result in conditions that degrade lean body mass and lower-body muscle function, which may be mediated by concomitant reductions in circulating testosterone. Methods We conducted a three-phase, proof-of-concept, single centre, randomised, double-blind, placebo-controlled trial ( CinicalTrials.gov , NCT02734238 ) of non-obese men: 14-d run-in, free-living, eucaloric diet phase; 28-d live-in, 55% exercise- and diet-induced energy deficit phase with (200 mg testosterone enanthate per week, Testosterone, n = 24) or without (Placebo, n = 26) exogenous testosterone; and 14-d recovery, free-living, ad libitum diet phase. Body composition was the primary end point; secondary endpoints included lower-body muscle function and health-related biomarkers. Findings Following energy deficit, lean body mass increased in Testosterone and remained stable in Placebo, such that lean body mass significantly differed between groups [mean difference between groups (95% CI), 2.5 kg (3.3, 1.6); P < .0001]. Fat mass decreased similarly in both treatment groups [0.2 (−0.4, 0.7), P = 1]. Change in lean body mass was associated with change in total testosterone (r = 0.71, P < .0001). Supplemental testosterone had no effect on lower-body muscle function or health-related biomarkers. Interpretation Findings suggest that supplemental testosterone may increase lean body mass during short-term severe energy deficit in non-obese, young men, but it does not appear to attenuate lower-body functional decline. Funding Collaborative Research to Optimize Warfighter Nutrition projects I and II, Joint Program Committee-5, funded by the US Department of Defence.

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Section: Methodsmentioning

confidence: 99%

Effects of testosterone supplementation on body composition and lower-body muscle function during severe exercise- and diet-induced energy deficit: A proof-of-concept, single centre, randomised, double-blind, controlled trial

et al. 2019

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“…The timing of the blood draw is important in younger men, whose testosterone levels have diurnal variation, with levels peaking early in the morning [33], but younger men were not included in this study. In older men (>45 years of age) such as most of those in our study, however, the diurnal effect on testosterone appears to be much less significant [34][35][36]. It should also be noted that the men in the UPOD study were all outpatients who were being tested for hypogonadism.…”

Section: Discussionmentioning

confidence: 53%

Association of low testosterone with changes in non-cardiovascular biomarkers in adult men

Samoszuk¹,

Morgentaler

Groot

et al. 2019

Int J Impot Res

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Testosterone has effects on many organs and systems. The purpose of this study was to test the hypothesis that low testosterone is associated with changes in various non-cardiovascular biomarkers in men older than 40 who were tested for possible hypogonadism. We extracted data from 9939 outpatient men who were over 40 years old (median age 56) and who also had concurrent laboratory measurements of total testosterone and one or more biomarkers of interest: estradiol, uric acid, prostate-specific antigen (PSA), sex-hormone binding globulin (SHBG), luteinizing hormone, creatinine, bone alkaline phosphatase (BAP), creatine kinase, hemoglobin A1c, and 25-hydroxy-vitamin D, and body mass index (BMI). In a smaller exploratory study of 19 otherwise healthy men presenting for evaluation of possible hypogonadism, pre-albumin (a.k.a. transthyretin, a marker of anabolism) and testosterone were measured. Men with lower levels of testosterone had significantly (p < 0.001) lower mean levels of PSA, SHBG, luteinizing hormone, and estradiol. Overall, men with low levels of testosterone also had significantly (p < 0.001) higher mean levels of LDH and BAP, but these associations varied between men who were younger or older than 56 years. There was a moderate but statistically significant positive correlation (r = 0.63, p < 0.05) between testosterone levels and pre-albumin. These results confirm our hypothesis that testosterone deficiency is associated with a broad range of systemic changes demonstrable in hormonal and non-hormonal serum assays in men over 40 years old being tested for possible hypogonadism.

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“…Between 7-8 AM, 5cc of blood was taken from the study subjects, by laboratory expert in the power plant dispensary, after 8-10 h fasting to measure the levels of free testosterone, LH, and FSH. 49 Blood samples were immediately placed in ice boxes and transferred to the laboratory, and their serum was separated, and stored at −20°C until the collection of all samples. 50 Serum levels of free testosterone, LH, and FSH were determined by an ELISA method using the StatFax 2100 ELISA reader at 450 nm, according to the kit manufacturer's protocol.…”

Section: Measurement Of the Serum Level Of Reproductive Hormonesmentioning

confidence: 99%

Relationship between exposure to Extremely Low-Frequency (ELF) magnetic field and the level of some reproductive hormones among power plant workers

Suri

Dehghan

Sahlabadi

et al. 2020

Journal of Occupational Health

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Background and Aims: Today, human beings are exposed to the ELF magnetic field of electrical equipment and power lines, which can damage Leydig cells and alter the secretion of reproductive hormones. The purpose of this study was to investigate the relationship between exposure to ELF magnetic field and the level of some reproductive hormones in male power plant workers. Materials and Methods: The present cross-sectional study was carried out among all male employees of different units of the selected power plant around Tehran, Iran. All participants were asked to complete demographic data sheets and General Health questionnaire, on condition of consent and meeting the inclusion criteria. Timeweighted average (TWA) exposure to magnetic field of 122 men was measured by IEEE Std C95.3.1 method using TES 1393 Gauss meter. Based on the exposure level, subjects were divided into three groups. Serum Levels of Free Testosterone, Luteinizing Hormone (LH), and Follicle stimulating hormone (FSH) in participants were determined. Data analysis was performed using ANOVA, Kruskal-Wallis tests, and the relationships between variables were assessed by linear regression and correlation using SPSS v.25 software. Results: There was no significant statistical correlation between the level of ELF exposure and serum levels of free testosterone, LH, and FSH, (r = 0.158). Serum levels of LH decreased significantly with age and duration of work experience (P < .05, r = −.25, P = .005, r = −.203, P = .025). Conclusion: There was no relationship between exposure to magnetic field in power plants and reproductive hormone levels, although it is impossible to make definitive comments without using more accurate methods to estimate male fertility. K E Y W O R D S extremely low-frequency magnetic field, men's reproductive hormones, occupational exposure, power plant 2 of 10 | SURI et al.

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Validity of Midday Total Testosterone Levels in Older Men with Erectile Dysfunction

Cited by 17 publications

References 19 publications

Effects of testosterone supplementation on body composition and lower-body muscle function during severe exercise- and diet-induced energy deficit: A proof-of-concept, single centre, randomised, double-blind, controlled trial

Effects of testosterone supplementation on body composition and lower-body muscle function during severe exercise- and diet-induced energy deficit: A proof-of-concept, single centre, randomised, double-blind, controlled trial

Association of low testosterone with changes in non-cardiovascular biomarkers in adult men

Relationship between exposure to Extremely Low-Frequency (ELF) magnetic field and the level of some reproductive hormones among power plant workers

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