Association of low testosterone with changes in non-cardiovascular biomarkers in adult men

Abstract

Testosterone has effects on many organs and systems. The purpose of this study was to test the hypothesis that low testosterone is associated with changes in various non-cardiovascular biomarkers in men older than 40 who were tested for possible hypogonadism. We extracted data from 9939 outpatient men who were over 40 years old (median age 56) and who also had concurrent laboratory measurements of total testosterone and one or more biomarkers of interest: estradiol, uric acid, prostate-specific antigen (PSA), sex-hormone binding globulin (SHBG), luteinizing hormone, creatinine, bone alkaline phosphatase (BAP), creatine kinase, hemoglobin A1c, and 25-hydroxy-vitamin D, and body mass index (BMI). In a smaller exploratory study of 19 otherwise healthy men presenting for evaluation of possible hypogonadism, pre-albumin (a.k.a. transthyretin, a marker of anabolism) and testosterone were measured. Men with lower levels of testosterone had significantly (p < 0.001) lower mean levels of PSA, SHBG, luteinizing hormone, and estradiol. Overall, men with low levels of testosterone also had significantly (p < 0.001) higher mean levels of LDH and BAP, but these associations varied between men who were younger or older than 56 years. There was a moderate but statistically significant positive correlation (r = 0.63, p < 0.05) between testosterone levels and pre-albumin. These results confirm our hypothesis that testosterone deficiency is associated with a broad range of systemic changes demonstrable in hormonal and non-hormonal serum assays in men over 40 years old being tested for possible hypogonadism.

Relationship between testosterone-estradiol ratio and some anthropometric and metabolic parameters among Nigerian men

“…There was a relationship between creatinine and the T/E2 ratio in our study. It is long believed that creatinine levels show an indirect measure of muscle mass [ 44 ], since an increase in muscle mass leads to the production of creatinine during muscle metabolism. Prior research has shown that testosterone levels in men correlate with creatinine levels [ 45 ], and it is suggestive that this correlation may be due to the stimulatory effect of testosterone on muscle mass.…”

Leveraging Nanomechanical Perturbations in Raman Spectro‐Immunoassays to Design a Versatile Serum Biomarker Detection Platform

“…Free thyroxine (T4) and testosterone with a molecular weight of 777 and 228 daltons were selected as a pair of model small molecules. While free T4, along with TSH, is an important biomarker for diagnosis of thyroid diseases and monitoring of therapeutical effects, [ 38 ] a low level of testosterone has been associated with variations in noncardiovascular biomarkers in above middle‐aged men [ 39 ] and even mortality based on most observational studies. [ 40 ] Owing to their small molecular weights, no appreciated SERS frequency shifts were observed after they were captured onto the antibody‐MBA conjugates‐functionalized gold nanopyramid array substrate ( Figure a,c).…”

Among Trauma Patients, Younger Men with Ventilator-Associated Pneumonia Have Worse Outcomes Compared to Older Men—An Exploratory Study

“…Testosterone has been shown to play a role in many organ systems, it is also known to decrease in older men [15] While gender differences in patients’ outcomes have been reported in patients who suffered from ruptured aortic aneurysms, traumatic head injury and Achilles tendon injury [16,17,18], large studies in trauma patients have not demonstrated a difference in outcome attributed to gender. Gannon et al, in a study of 22,332 trauma patients admitted to trauma centers in Pennsylvania over two years, found that female gender did not affect mortality when stratified for ISS and age, and Magnotti et al, in a retrospective analysis of trauma patients over ten years, found gender not to be associated with mortality [10,11].…”