Validity of apparent diffusion coefficient hyperpolarized 3He-MRI using MSCT and pulmonary function tests as references

Diaz, Sandra; Casselbrant, Ingrid; Piitulainen, Eeva; Magnusson, Peter; Peterson, Barry T.; Wollmer, Per; Leander, Peter; Ekberg, Olle; Åkeson, Per

doi:10.1016/j.ejrad.2008.04.013

Cited by 60 publications

(38 citation statements)

References 23 publications

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“…Whole-lung quantitative CT-derived emphysema showed a similar correlation with Tlco, providing evidence that hyperpolarized 129 Xe MR imaging-derived ADC measurements reflect emphysematous destruction of the pulmonary microstructure. The relationship between hyperpolarized gas MR imaging-derived ADC, quantitative CT-derived emphysema, and Tlco is established in patients with and patients without COPD (26,28), in keeping with our results.…”

Section: Discussionsupporting

confidence: 78%

“…A possible explanation may be that 129 Xe MR imaging provides regional measurements of lung function, imaging in 10 subjects with COPD and showed significant correlation between regions of decreased hyperpolarized 129 Xe MR imaging-derived ventilation with quantitative CT-derived emphysema but not quantitative CT-derived airway wall measurement. Significant correlation between hyperpolarized 3 He MR imaging-derived ADC and quantitative CT-derived emphysema has been similarly reported (26). The relationship between whole-lung hyperpolarized 129 Xe MR imaging-derived ADC and quantitative CT-derived emphysema in healthy volunteers and patients with COPD has also been demonstrated (27).…”

Section: Discussionmentioning

confidence: 67%

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Chronic Obstructive Pulmonary Disease: Lobar Analysis with Hyperpolarized ¹²⁹Xe MR Imaging

et al. 2017

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Purpose:To compare lobar ventilation and apparent diffusion coefficient (ADC) values obtained with hyperpolarized xenon 129 ( 129 Xe) magnetic resonance (MR) imaging to quantitative computed tomography (CT) metrics on a lobar basis and pulmonary function test (PFT) results on a wholelung basis in patients with chronic obstructive pulmonary disease (COPD). Materials andMethods:The study was approved by the National Research Ethics Service Committee; written informed consent was obtained from all patients. Results:Percentage ventilated volume and average ADC at lobar 129 Xe MR imaging showed correlation with percentage emphysema at lobar quantitative CT (r = 20.32, P , .001 and r = 0.75, P , .0001, respectively). The average ADC at whole-lung 129 Xe MR imaging showed moderate correlation with PFT results (percentage predicted transfer factor of the lung for carbon monoxide [Tlco]: r = 20.61, P , .005) and percentage predicted functional residual capacity (r = 0.47, P , .05). Whole-lung quantitative CT percentage emphysema also showed statistically significant correlation with percentage predicted Tlco (r = 20.65, P , .005). Conclusion:Lobar ventilation and ADC values obtained from hyperpolarized 129Xe MR imaging demonstrated correlation with quantitative CT percentage emphysema on a lobar basis and with PFT results on a whole-lung basis.q RSNA, 2016

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 67%

Chronic Obstructive Pulmonary Disease: Lobar Analysis with Hyperpolarized ¹²⁹Xe MR Imaging

et al. 2017

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“…Correlations between CT results and the 3 He apparent diffusion coefficient also have been observed ( 40,41 ). Both Diaz et al ( 40 ) and van Beek had mild disease and lacked the gross tissue destruction that reduces the gas exchange area suffi ciently to alter diffusion capacity of carbon monoxide.…”

Section: Thoracic Imagingmentioning

confidence: 66%

“…Both Diaz et al ( 40 ) and van Beek had mild disease and lacked the gross tissue destruction that reduces the gas exchange area suffi ciently to alter diffusion capacity of carbon monoxide. vol ume used.…”

Section: Thoracic Imagingmentioning

confidence: 99%

In Vivo Detection of Acinar Microstructural Changes in Early Emphysema with³He Lung Morphometry

Quirk

Lutey²,

Gierada³

et al. 2011

Radiology

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Purpose:To quantitatively characterize early emphysematous changes in the lung microstructure of current and former smokers with noninvasive helium 3 ( 3 He) lung morphometry and to compare these results with the clinical standards, pulmonary function testing (PFT) and low-dose computed tomography (CT). Materials and Methods:This study was approved by the local institutional review board, and all subjects provided informed consent. Thirty current and former smokers, each with a minimum 30-packyear smoking history and mild or no abnormalities at PFT, underwent 3He lung morphometry. This technique is based on diffusion MR imaging with hyperpolarized 3 He gas and yields quantitative localized in vivo measurements of acinar airway geometric parameters, such as airway radii, alveolar depth, and number of alveoli per unit lung volume. These measurements enable calculation of standard morphometric characteristics, such as mean linear intercept and surface-to-volume ratio. Results:Noninvasive 3 He lung morphometry was used to detect alterations in acinar structure in smokers with normal PFT fi ndings. When compared with smokers with the largest forced expiratory volume in 1 second (FEV 1 ) to forced vital capacity (FVC) ratio, those with chronic obstructive pulmonary disease had signifi cantly reduced alveolar depth (0.07 mm vs 0.13 mm) and enlarged acinar ducts (0.36 mm vs 0.3 mm). The mean alveolar geometry measurements in the healthiest subjects were in excellent quantitative agreement with literature values obtained by using invasive techniques (acinar duct radius, 0.3 mm; alveolar depth, 0.14 mm at 1 L above functional residual capacity).3 He lung morphometry depicted greater abnormalities than did PFT and CT. No adverse events were associated with inhalation of 3 He gas. Conclusion:3 He lung morphometry yields valuable noninvasive insight into early emphysematous changes in alveolar geometry with increased sensitivity compared with conventional techniques.

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“…This technique was first demonstrated by Chen et al [138] and has since been shown to assist in early disease detection [139], and monitoring of disease progression [140]. The HP 3 He-MRI ADC measures also correlate with histology [141] and computed tomography measures of emphysema and air trapping [142]. Wang et al [136] showed that asthmatic subjects had significantly increased short-range and long-range ADC times when compared to healthy controls.…”

Section: Apparent Diffusion Coefficientmentioning

confidence: 95%

Novel imaging approaches in adult asthma and their clinical potential

Hartley

Baldi

Brightling

et al. 2015

Expert Review of Clinical Immunology

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Currently, imaging in asthma is confined to chest radiography and CT. The emergence of new imaging techniques and tremendous improvement of existing imaging methods, primarily due to technological advancement, has completely changed its research and clinical prospects. In research, imaging in asthma is now being employed to provide quantitative assessment of morphology, function and pathogenic processes at the molecular level. The unique ability of imaging for non-invasive, repeated, quantitative, and in vivo assessment of structure and function in asthma could lead to identification of 'imaging biomarkers' with potential as outcome measures in future clinical trials. Emerging imaging techniques and their utility in the research and clinical setting is discussed in this review.

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Validity of apparent diffusion coefficient hyperpolarized 3He-MRI using MSCT and pulmonary function tests as references

Cited by 60 publications

References 23 publications

Chronic Obstructive Pulmonary Disease: Lobar Analysis with Hyperpolarized ¹²⁹Xe MR Imaging

Chronic Obstructive Pulmonary Disease: Lobar Analysis with Hyperpolarized ¹²⁹Xe MR Imaging

In Vivo Detection of Acinar Microstructural Changes in Early Emphysema with³He Lung Morphometry

Novel imaging approaches in adult asthma and their clinical potential

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Validity of apparent diffusion coefficient hyperpolarized 3He-MRI using MSCT and pulmonary function tests as references

Cited by 60 publications

References 23 publications

Chronic Obstructive Pulmonary Disease: Lobar Analysis with Hyperpolarized 129Xe MR Imaging

Chronic Obstructive Pulmonary Disease: Lobar Analysis with Hyperpolarized 129Xe MR Imaging

In Vivo Detection of Acinar Microstructural Changes in Early Emphysema with3He Lung Morphometry

Novel imaging approaches in adult asthma and their clinical potential

Contact Info

Product

Resources

About

Chronic Obstructive Pulmonary Disease: Lobar Analysis with Hyperpolarized ¹²⁹Xe MR Imaging

Chronic Obstructive Pulmonary Disease: Lobar Analysis with Hyperpolarized ¹²⁹Xe MR Imaging

In Vivo Detection of Acinar Microstructural Changes in Early Emphysema with³He Lung Morphometry