Validity of an adaptation of the Framingham cardiovascular risk function: the VERIFICA study

Marrugat, Jaume; Subirana, Isaac; Comín, E.; Cabezas, Carmen; Vila, Joan; Elosúa, Roberto; Nam, Byung Ho; Ramos, Rafel; Sala, Joan; Solanas, Pascual; Cordón, Ferrán; Badía, Joan Gené; D’Agostino, Ralph B.

doi:10.1136/jech.2005.038505

Cited by 271 publications

(137 citation statements)

References 30 publications

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“…The consumption of other substances (hashish, alcohol, cocaine, heroin and methadone) was provided by the patient. The Regicor scale [12] (Framingham scale adapted to the Spanish population) was used to identify CV risk. In phase 2, pharmacological treatment was assessed and the use of bupropion, varenicline and/or NRT was considered.…”

Section: Methodsmentioning

confidence: 99%

Smoking cessation in HIV patients: rate of success and associated factors

et al. 2009

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Smoking is the modifiable cardiovascular (CV) risk factor that contributes most to causing premature CV disease. Prevalence of smoking in patients with HIV infection is double that of the general population. ObjectivesTo determine the rate of patients succeeding in quitting smoking after 12 months, factors associated with this success, and the characteristics of tobacco consumption and nicotine dependence. MethodsLongitudinal descriptive study. Three hundred and sixty-eight HIV-infected patients were interviewed. Smokers in Prochaska's stage of action began a programme to quit smoking. We registered the variables related to tobacco consumption and the level of success of cessation. Results 63.9% of the patients were active smokers and 14% of them began the cessation programme. Average motivation for cessation was 7.8 AE 1.4 (Richmond) and nicotine dependence rate 5.5 AE 3.0 (Fagerströ m). After 1 year, 25% had quit smoking. Those patients who stopped smoking presented a higher motivation level (8.8 AE 1.3 vs. 7.5 AE 1.5, P 5 0.048). Cessation significantly reduced their CV risk at 12 months {2.5 [interquartile range (IQR) 2.0-5.2] vs. 1.7 [IQR 1.0-3.5], P 5 0.026}. ConclusionsThe prevalence of smokers in our population of HIV-infected patients was 63.9%. Only 14% began a smoking cessation programme. Twelve months after a programme to quit smoking, cessation rate was 25%; this was influenced mostly by the level of motivation of the patient.

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Section: Methodsmentioning

confidence: 99%

Smoking cessation in HIV patients: rate of success and associated factors

et al. 2009

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“…REGICOR is the Framingham model calibrated for the Spanish population (7)(8)(9). To calculate this scale of cardiovascular risk data on age, sex, tobacco consumption, systolic and diastolic blood pressure, cholesterol, HDL cholesterol, and diabetes are needed.…”

Section: Measurements and Calculationsmentioning

confidence: 99%

Relationship between blood glucose levels and cardiovascular risk in the Spanish Mediterranean population

Manzanero¹,

López-González²,

García-Agudo³

et al. 2017

Turk J Med Sci

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Background/aim: Diabetes is associated with an increased prevalence of cardiovascular disease. Impaired fasting glucose (IFG) is an intermediate clinical situation between normal glucose levels and type 2 diabetes. The aim of this study is to determine how fasting glucose concentrations affect different cardiovascular risk scales. Materials and methods:A descriptive study was conducted with 59,041 Mediterranean Spanish workers. IFG was determined using the American Diabetes Association (ADA) and the World Health Organization (WHO) criteria. Different indicators of cardiovascular risk were analyzed: body mass index, waist circumference, waist-to-height ratio, blood pressure, lipid parameters, atherogenic indices, metabolic syndrome, and various scales of cardiovascular risk such as REGICOR, DORICA, SCORE, Heart Age, and Vascular Age.Results: All cardiovascular scales showed statistically significant differences between the IFG group and the normal glucose group. In all cases, values were worse in the IFG group; furthermore, men exhibited more unfavorable levels of cardiovascular risk factors than women. Higher odds ratio values were present in employees with metabolic syndrome according to ATP III criteria (9.42, 95% CI: 8.56-10.37 using WHO criteria and 9.25, 95% CI: 8.67-9.87 using ADA criteria).Conclusions: IFG increases cardiovascular risk whether using classical scales (REGICOR, SCORE, and metabolic syndrome) or other less studied scales (atherogenic indices, Heart Age, and Vascular Age).

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“…42,43,44 Moreover, the differences between observed and expected risk levels could be significant within some risk percentiles, 45 especially when unvalidated local risk estimation systems are used. 46,47,48 For example, the differences on the expected average risk for a sample of Koreans subjects using the Framingham score (7.65%) and the "local" Korea score (1.67%) is substantial. 48 Recalibration of the Framingham score for the Spanish population showed that the levels of absolute total CVR should be different in Spain.…”

mentioning

confidence: 99%

“…48 Recalibration of the Framingham score for the Spanish population showed that the levels of absolute total CVR should be different in Spain. 47 The predictive value of the risk models is affected by the presence of factors that are usually not included in the CVR models, such as low physical activity, obesity, being of low socioeconomic status and other psychological factors, pre-DM, a family history of premature CVD, or increased triglycerides, fibrinogen, apolipoprotein B, lipoprotein(a) levels and high-sensitivity Creactive protein. 9 In addition, it is important to point out that there are no validated tables for most low and middle income countries, where over three quarters of deaths from CVD occur.…”

mentioning

confidence: 99%

Clinical Perspective on Antihypertensive Drug Treatment in Adults With Grade 1 Hypertension and Low-to-Moderate Cardiovascular Risk: An International Expert Consultation

Salinas¹,

Coca

Olsen

et al. 2017

Current Problems in Cardiology

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Validity of an adaptation of the Framingham cardiovascular risk function: the VERIFICA study

Abstract: The Framingham function adapted to local population characteristics accurately and reliably predicted the 5-year CHD risk for patients aged 35-74 years, in contrast with the original function, which consistently overestimated the actual risk.

Cited by 271 publications

References 30 publications

Smoking cessation in HIV patients: rate of success and associated factors

Smoking cessation in HIV patients: rate of success and associated factors

Relationship between blood glucose levels and cardiovascular risk in the Spanish Mediterranean population

Clinical Perspective on Antihypertensive Drug Treatment in Adults With Grade 1 Hypertension and Low-to-Moderate Cardiovascular Risk: An International Expert Consultation

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