Relationship between blood glucose levels and cardiovascular risk in the Spanish Mediterranean population

Abstract

Background/aim: Diabetes is associated with an increased prevalence of cardiovascular disease. Impaired fasting glucose (IFG) is an intermediate clinical situation between normal glucose levels and type 2 diabetes. The aim of this study is to determine how fasting glucose concentrations affect different cardiovascular risk scales. Materials and methods:A descriptive study was conducted with 59,041 Mediterranean Spanish workers. IFG was determined using the American Diabetes Association (ADA) and the World Health Organization (WHO) criteria. Different indicators of cardiovascular risk were analyzed: body mass index, waist circumference, waist-to-height ratio, blood pressure, lipid parameters, atherogenic indices, metabolic syndrome, and various scales of cardiovascular risk such as REGICOR, DORICA, SCORE, Heart Age, and Vascular Age.Results: All cardiovascular scales showed statistically significant differences between the IFG group and the normal glucose group. In all cases, values were worse in the IFG group; furthermore, men exhibited more unfavorable levels of cardiovascular risk factors than women. Higher odds ratio values were present in employees with metabolic syndrome according to ATP III criteria (9.42, 95% CI: 8.56-10.37 using WHO criteria and 9.25, 95% CI: 8.67-9.87 using ADA criteria).Conclusions: IFG increases cardiovascular risk whether using classical scales (REGICOR, SCORE, and metabolic syndrome) or other less studied scales (atherogenic indices, Heart Age, and Vascular Age).

Development of a Predictive Model of Cardiovascular Risk in a Male Population from the Peruvian Amazon

“…In addition, based on the previous experience of other authors with Mediterranean populations from Spain [22], we related the items that compose the FINDRISC test and its cutoff points with factors that predispose the presence or increase in CR. It was highly significant when the test scores were grouped dichotomously between high and low risk to be related to HT, T2DM, obesity, and CR.…”

Factors correlated with targeted prevention for prediabetes classified by impaired fasting glucose, impaired glucose tolerance, and elevated HbA1c: A population-based longitudinal study

“…We found that hypertension was correlated with increased risk for prediabetes, which was consistent with previous studies ( 14 , 45 ). For the aspect of dyslipidemia, a Spanish study reported the association of TC, LDL-c, and TG with IFG ( 48 ). A study of Mexican-Americans detected that HDL-c and TG were related to prediabetes, and no associations were found in TC and LDL-c ( 43 ).…”

Prediabétesz és kardiovaszkuláris kockázat

“…), így erre is fokozott figyelemmel kell lenni. López-Gonzalez és munkatársai például azt találták, hogy az általuk vizsgált közel 60 000 spanyol munkás között azok, akiknél IFG igazolódott nagyobb volt a különböző CV-rizikóbecslő rendszerrel (REGICOR, SCORE) számított CV kockázata a normoglykaemiásokhoz képest (17), Martinez-Larrad és munkatársai pedig IGT esetében bizonyították ezt egy közel 4000 fős, véletlenszerűen kiválasztott kohortban (18). Kérdés, hogy az inzulinrezisztenciának milyen szerepe van az ateroszklerózis és így a fokozott CV-kockázat kialakulásában.…”