Validity and Reliability of the Turkish Version of the Nuss Questionnaire Modified for Adults

Bahadir, A. Tugba; Kuru, Pinar; Afacan, Ceyda; Ermerak, Nezih Onur; Bostancı, Korkut; Yüksel, Mustafa

doi:10.5090/kjtcs.2015.48.2.112

Cited by 12 publications

(12 citation statements)

References 16 publications

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“…Fluorescence resonance energy transfer (FRET) is a distance‐dependent interaction in which excitation energy is transferred non‐radiatively from the donor molecule to the acceptor molecule . The efficiency of FRET is dependent on the extent of spectral overlap of the emission spectrum of the donor with the absorption spectrum of the acceptor, the relative orientation of the donor and acceptor transition dipoles, and the distance between the donor and acceptor molecules . What's more, FRET is an important technique to investigate a variety of biological phenomena such as fluorescence quenching .…”

Section: Resultsmentioning

confidence: 99%

“…The efficiency of FRET is dependent on the extent of spectral overlap of the emission spectrum of the donor with the absorption spectrum of the acceptor, the relative orientation of the donor and acceptor transition dipoles, and the distance between the donor and acceptor molecules . What's more, FRET is an important technique to investigate a variety of biological phenomena such as fluorescence quenching . According to Forster's non‐radiative energy transfer theory, the efficiency of energy transfer ( E ) between the donor and the acceptor can be determined by the following equation:

E = 1 - \frac{F}{F_{0}} = \frac{{R_{0}}^{6}}{{R_{0}}^{6} + {R_{0}}^{6}}

where E is the energy transfer efficiency between donor and acceptor, F 0 and F are the fluorescence intensities of donor in the absence or presence of acceptor molecule, r 0 is the distance between the donor and the acceptor, R 0 which defined as the critical distance at which the energy transfer efficiency is 50%, which can be calculated using the equation:

{R_{0}}^{6} = 8.79 \times 10^{- 25} \cdot k^{2} \cdot n^{- 4} \cdot normalΦ \cdot J ((),, λ)

where k 2 is the spatial orientation factor and k ' = 2/3, n is the refractive index for the medium and n = 1.336, Φ is the fluorescence quantum yield of the donor and Φ = 0.118 for BSA .…”

Section: Resultsmentioning

confidence: 99%

“…[40] The efficiency of FRET is dependent on the extent of spectral overlap of the emission spectrum of the donor with the absorption spectrum of the acceptor, the relative orientation of the donor and acceptor transition dipoles, and the distance between the donor and acceptor molecules. [41][42][43] What's more, FRET is an important technique to investigate a variety of biological phenomena such as fluorescence quenching. [41] According to Forster's non-radiative energy transfer theory, [44] the efficiency of energy transfer (E) between the donor and the acceptor can be determined by the following equation:…”

Section: Energy Transfer From Bsa To Five Compoundsmentioning

confidence: 99%

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Spectroscopic and molecular docking study on the structure–affinity relationship and mechanism in the interaction of genistein and its derivatives with bovine serum albumin

Guo

Shen

et al. 2017

Luminescence

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In this paper, the interaction of genistein (GEN) and its four derivatives (GEN1-4) with bovine serum albumin (BSA) were investigated by ultraviolet-visible absorption spectra, fluorescence, synchronous fluorescence, three-dimensional fluorescence spectroscopy, circular dichroism and molecular docking techniques. The experimental results showed that the intrinsic fluorescence of BSA was quenched by genisteins and was due to the formation of a genisteins-BSA complex. The quenching constant, binding constants, binding sites, intermolecular distances and thermodynamic properties were calculated at 298 K, 306 K and 310 K. Site marker competitive experiments indicated that the binding site of genisteins to BSA was mainly located in subdomain IIA. The conformational investigation showed that the presence of 0020 genisteins led to changes in the secondary structure of BSA and induced the slight unfolding of protein polypeptides, which confirmed some micro-environmental and conformational changes of BSA molecules. Furthermore, the binding affinity decreased in the order GEN1 > GEN > GEN4 > GEN3 > GEN2, which revealed that different type and position of substituents of genistein significantly influenced the affinity of compounds to BSA. The number of hydroxyl groups on the ring A was the most important factor because increasing the hydroxyl groups on ring A clearly enhanced the binding affinity. However, trifluoromethylation did not much affect the affinity, alkylation, esterification and difluoromethylation slightly enhanced the binding affinity. The results obtained herein will provide valuable information about the pharmacokinetics at a molecular level and be a useful guideline for the further design of much more suitable genistein derivatives.

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Section: Resultsmentioning

confidence: 99%

E = 1 - \frac{F}{F_{0}} = \frac{{R_{0}}^{6}}{{R_{0}}^{6} + {R_{0}}^{6}}

{R_{0}}^{6} = 8.79 \times 10^{- 25} \cdot k^{2} \cdot n^{- 4} \cdot normalΦ \cdot J ((),, λ)

where k 2 is the spatial orientation factor and k ' = 2/3, n is the refractive index for the medium and n = 1.336, Φ is the fluorescence quantum yield of the donor and Φ = 0.118 for BSA .…”

Section: Resultsmentioning

confidence: 99%

Section: Energy Transfer From Bsa To Five Compoundsmentioning

confidence: 99%

See 1 more Smart Citation

Spectroscopic and molecular docking study on the structure–affinity relationship and mechanism in the interaction of genistein and its derivatives with bovine serum albumin

Guo

Shen

et al. 2017

Luminescence

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“…In PE sternal and costal depression and in PC sternal and costal protrusion are prominent. Since pectus deformities may cause both physical and psychological problems, issues related to the quality of life of these patients are of particular concern (2)(3)(4)(5). Pectus deformities were found to be associated with decreased quality of life, low self-esteem, and increased psychosocial problems (3,(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Psychosocial functioning in pediatric patients with pectus excavatum and pectus carinatum

Bahadir¹,

Bektaşoğlu²,

Eser³

et al. 2017

Turk J Med Sci

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Background/aim: Pectus excavatum and pectus carinatum are the most commonly seen anterior chest wall deformities. Recent studies reveal that minimal invasive repair of pectus deformities improves the quality of life. Our aim is to assess the psychosocial functioning and sociodemographic characteristics of pediatric patients with pectus deformities and evaluate the differences between patients operated on with minimal invasive repair techniques and nonoperated patients.Materials and methods: Thirty-two patients with pectus deformities who were operated on 6 months or more before and 31 nonoperated patients participated in the study. The Children's Depression Inventory, Piers-Harris Children's Self-Concept Scale, Capa Social Phobia Scale for Children and Adolescents, Strengths and Difficulties Questionnaire -Self-Report Version (SDQ-SR), and State-Trait Anxiety Inventory for Children -Trait Version were completed by the patients. The SDQ-Parent Report Version (SDQ-PR) was completed by their parents.Results: There were no statistically significant differences between operated and nonoperated patient groups in terms of total scores on the psychiatric rating scales. Prosocial behavior subscale scores in SDQ-SR (P = 0.013) and SDQ-PR (P = 0.019) were lower in the operated group. Conclusion:Prosocial behavior levels were lower in the operated group. Further exploration of the psychosocial profile of pediatric patients with pectus deformities would better elucidate their needs in the course of their socioemotional development.

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“…2,3 Nevertheless, PE cases have mostly been a cosmetic defect including issues regarding body image which may significantly impact a person's quality of life, low self-esteem, and increased psychosocial problems with PE patients mostly complaining of chest pain, difficulty breathing, decreased cardiac output and decreased exercise capacity depending on its severity. [4][5][6][13][14][15][16][17] Morphological differences in pectus excavatum may result in different effects on pulmonary function as well as cardiac morphology and function. 5,6 Symptoms of untreated patients can progress with age, and it's recommended that the deformity is surgically treated in both young and adult patients.…”

Section: Introductionmentioning

confidence: 99%

Pectus excavactum-insights into its diagnosis and the current treatment options along with its clinical outcomes: two case reports

et al. 2018

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Pectus excavatum (PE) is a congenital sternal depression, one of the most frequent major congenital malformations of the chest wall. Generally, the malformation is not associated with functional disorders and often constitutes an aesthetic alteration with significant psychological distress. Nevertheless, the surgical repair of PE in childhood has been a well-established procedure with modified Ravitch repair (MRR) and minimally invasive repair (MIR) by Nuss been the two most popular methods of corrections. As a means of concealing the ugly skin scars caused by the MRR technique, the procedure was however highly modified with the use of bilateral inframammarian separated skin incisions. However, MIR has been a preferable technique due to its shorter operative time and minimal blood loss, but its postoperative complications have so far seemed to be its limiting factor whereas, extensive and combined deformities of the ventral chest wall are classically corrected using either MIR by Nuss and the MRR technique. Notwithstanding, Conservative treatment using alloplastic implants or vacuum bell to elevate the sternum in patients with mild PE defect is becoming a potential alternative and a means of preventing unnecessary surgical procedures mostly in mild funnel chest. Presented here is a case of PE surgical correction in a 12-year-old boy and an 11-year-old girl with pectus bar dislodgment. This article analyses the chain of events between both patients, reviews the literature on the subject and other currently available treatment options.

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Validity and Reliability of the Turkish Version of the Nuss Questionnaire Modified for Adults

Cited by 12 publications

References 16 publications

Spectroscopic and molecular docking study on the structure–affinity relationship and mechanism in the interaction of genistein and its derivatives with bovine serum albumin

Spectroscopic and molecular docking study on the structure–affinity relationship and mechanism in the interaction of genistein and its derivatives with bovine serum albumin

Psychosocial functioning in pediatric patients with pectus excavatum and pectus carinatum

Pectus excavactum-insights into its diagnosis and the current treatment options along with its clinical outcomes: two case reports

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