Validity and reliability of the Ankylosing Spondylitis Disease Activity Score with C‐reactive protein (ASDAS‐CRP) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in patients with axial spondyloarthritis (axSpA) in Singapore

Kwan, Yu Heng; Tan, Jun; Phang, Jie Kie; Fong, Warren; Lim, Ka Keat; Koh, Hwee‐Ling; Lui, Nai Lee; Tan, Chuen Seng; Østbye, Truls; Thumboo, Julian; Leung, Ying Ying

doi:10.1111/1756-185x.13735

Cited by 24 publications

(16 citation statements)

References 26 publications

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“…The correlation coefficients between the BASDAI and ASDAS-CRP/ASDAS-ESR were 0.7203/0.7590 ( p < 0.0001, both), which were consistent with those reported in prior studies ( 7 , 16 – 18 ). Our data determined the disease activity state cut-offs for BASDAI at 2.1/2.0, 3.1/2.6, and 3.7/4.8 for inactive disease, low disease activity, high disease activity, and very high disease activity, while using ASDAS-CRP/ASCAS-ESR as references.…”

Section: Discussionsupporting

confidence: 90%

The BASDAI Cut-Off for Disease Activity Corresponding to the ASDAS Scores in a Taiwanese Cohort of Ankylosing Spondylitis

et al. 2022

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ObjectivesThe Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) has been widely utilized to evaluate disease activity in patients with ankylosing spondylitis (AS) by an arbitrary cut-off of ≥4 to indicate high disease activity and initiate biological therapy. The Ankylosing Spondylitis Disease Activity Score (ASDAS) is a new composite index to assess AS disease activity states that have been defined and validated. ASDAS ≥2.1 was selected as a criterion to start biological therapy. The purpose of this study was to estimate the corresponding BASDAI and ASDAS cut-off in a Taiwanese AS cohort.MethodsFrom November 2016 to October 2018, we assessed the ASDAS and the BASDAI regularly and recorded demographic data for 489 AS patients in Taichung Veterans General hospital (TCVGH) using an electronic patient-reported data system linked to electronic medical records. We used receiver operating characteristic curves with Youden's J statistic to determine the BASDAI values that correspond to ASDAS disease activity cut-offs (i.e., 1.3, 2.1, and 3.5).ResultsIn our population, the best trade-off BASDAI values corresponding to ASDAS -C-reactive protein (CRP) 1.3, 2.1, and 3.5 were 2.1, 3.1, and 3.7, respectively. The optimal BASDAI values corresponding to ASDAS-erythrocyte sedimentation rates 1.3, 2.1, and 3.5 were 2.0, 2.6, and 4.8, respectively.ConclusionWe propose a revised BASDAI cut-off based on our data, as BASDAI scores are commonly used globally. A more reasonable, lower BASDAI cut-off to initiate or change biological therapy will bring us closer to better decisions to treat AS patients.

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Section: Discussionsupporting

confidence: 90%

The BASDAI Cut-Off for Disease Activity Corresponding to the ASDAS Scores in a Taiwanese Cohort of Ankylosing Spondylitis

et al. 2022

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“…Patient-reported outcomes included the validated Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), pain score, patient global assessment (PtGA), Health Assessment Questionnaire-Disability Index (HAQ-DI), and the 36-item Short Form Health Survey (SF-36), all of which have been validated in the Asian context for patients with SpA 17,18,19,20,21 . The BASDAI consisted of 5 domains including fatigue, back pain, peripheral joint pain, enthesitis pain, and morning stiffness (severity and duration), collected on a 0-10 NRS, with 10 indicating worse severity; the mean of the 5 domains was scored.…”

Section: Methodsmentioning

confidence: 99%

Residual Disease Burden in Patients With Axial Spondyloarthritis and Psoriatic Arthritis Despite Low Disease Activity States in a Multiethnic Asian Population

et al. 2020

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Objective To evaluate the burden of residual disease in patients with axial SpondyloArthritis (axSpA) or Psoriatic Arthritis (PsA) who achieved low disease activity status. Methods We used baseline data from a clinic registry of SpA in a tertiary hospital in Singapore. For axSpA, LDA was defined as ASDAS-ESR <2.1 or BASDAI <3/10. For PsA, LDA was defined by achieving 5/7 cut-offs in the Minimal Disease Activity (MDA) or clinical Disease Activity index for Psoriatic Arthritis (cDAPSA) ≤13. Results From 262 cases of axSpA (21% women; mean ± standard deviation (SD) age 42 ± 14 years), 33% and 43% of patients achieved ASDAS-ESR and BASDAI LDA states respectively. While from 142 cases of PsA (49% women; mean ± SD age 51 ± 14 years), 35% and 63% achieved MDA and cDAPSA LDA, respectively. Both axSpA and PsA patients with LDA had pain scores range from 14.0 to 21.4/100 and fatigue scores from 3.1 to 3.6/10. Substantial burden in physical disability and mental wellbeing were observed with low physical and mental component summary of SF-36. AxSpa patients in BASDAI LDA had higher ESR and lower disability than those in ASDAS-ESR LDA. cDAPSA classified nearly twice as many PsA patients into LDA than MDA. Compared to PsA patients in MDA LDA, PsA patients in cDAPSA LDA had higher active joint counts, dactylitis, enthesitis, pain scores and patient global assessment (PtGA) Conclusion Despite being in LDA, patients with axSpA and PsA experienced substantial residual burden in pain, fatigue, poorer functional health and mental well-being.

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“…The BASDAI has construct validity in that it is correlated with the Ankylosing Spondylitis Quality of Life Index (ASQoL), the ASAS Health Index (ASAS HI), the Bath Ankylosing Spondylitis Function Index (BASFI), the Bath Ankylosing Spondylitis Global Score (BAS‐G), and others (35–42).…”

Section: Bath Ankylosing Spondylitis Disease Activity Index (Basdai)mentioning

confidence: 99%

“…Four of the items in the ASDAS are taken from the BASDAI, and these items in general have good reliability (19). A single‐center study has shown poor internal consistency (Cronbach’s α = 0.33) (40).…”

Section: Ankylosing Spondylitis Disease Activity Score (Asdas)mentioning

confidence: 99%

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Measuring Outcomes in Axial Spondyloarthritis

Ogdie

Duarte‐García

Hwang

et al. 2020

Arthritis Care & Research

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Validity and reliability of the Ankylosing Spondylitis Disease Activity Score with C‐reactive protein (ASDAS‐CRP) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in patients with axial spondyloarthritis (axSpA) in Singapore

Cited by 24 publications

References 26 publications

The BASDAI Cut-Off for Disease Activity Corresponding to the ASDAS Scores in a Taiwanese Cohort of Ankylosing Spondylitis

The BASDAI Cut-Off for Disease Activity Corresponding to the ASDAS Scores in a Taiwanese Cohort of Ankylosing Spondylitis

Residual Disease Burden in Patients With Axial Spondyloarthritis and Psoriatic Arthritis Despite Low Disease Activity States in a Multiethnic Asian Population

Measuring Outcomes in Axial Spondyloarthritis

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