Objective To evaluate the burden of residual disease in patients with axial SpondyloArthritis (axSpA) or Psoriatic Arthritis (PsA) who achieved low disease activity status. Methods We used baseline data from a clinic registry of SpA in a tertiary hospital in Singapore. For axSpA, LDA was defined as ASDAS-ESR <2.1 or BASDAI <3/10. For PsA, LDA was defined by achieving 5/7 cut-offs in the Minimal Disease Activity (MDA) or clinical Disease Activity index for Psoriatic Arthritis (cDAPSA) ≤13. Results From 262 cases of axSpA (21% women; mean ± standard deviation (SD) age 42 ± 14 years), 33% and 43% of patients achieved ASDAS-ESR and BASDAI LDA states respectively. While from 142 cases of PsA (49% women; mean ± SD age 51 ± 14 years), 35% and 63% achieved MDA and cDAPSA LDA, respectively. Both axSpA and PsA patients with LDA had pain scores range from 14.0 to 21.4/100 and fatigue scores from 3.1 to 3.6/10. Substantial burden in physical disability and mental wellbeing were observed with low physical and mental component summary of SF-36. AxSpa patients in BASDAI LDA had higher ESR and lower disability than those in ASDAS-ESR LDA. cDAPSA classified nearly twice as many PsA patients into LDA than MDA. Compared to PsA patients in MDA LDA, PsA patients in cDAPSA LDA had higher active joint counts, dactylitis, enthesitis, pain scores and patient global assessment (PtGA) Conclusion Despite being in LDA, patients with axSpA and PsA experienced substantial residual burden in pain, fatigue, poorer functional health and mental well-being.