Validation study of the Access antimüllerian hormone assay for the prediction of poor ovarian response to controlled ovarian stimulation

Baker, Valerie L.; Glassner, M.J.; Doody, Kevin J.; Schnell, Vicki L.; Gracia, Clarisa R.; Shin, Sanghyuk S.; Behera, Millie A.; Saint, Cécile Maria Le; Alper, Michael M.; Pavone, Mary Ellen; Zbella, Edward A.; Coddington, Charles C.; Marshall, Lorna; Feinberg, Ronald F.; Cooper, Amber R.; Straseski, Joely A.; Broyles, Dennis L.

doi:10.1016/j.fertnstert.2021.01.056

Cited by 8 publications

(2 citation statements)

References 20 publications

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“…AMH is involved in regulating early ovarian follicular growth and cyclic follicular selection 17 , 18 . Consistent with AMH being a strong correlate of oocyte yield, AMH has recently been proposed as a useful clinical marker for the prediction of both poor- and hyperresponses to ovarian stimulation 19 . Several authors have found a significant positive correlation between AMH concentrations and oocyte quality, fertilization rate and embryo morphology 20 – 22 .…”

Section: Discussionmentioning

confidence: 91%

A validated model for individualized prediction of pregnancy outcome in woman after fresh cycle of Day 5 single blastocyst transfer

Chen

Jiang

et al. 2023

Sci Rep

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The association between the embryo quality, clinical characteristics, miRNAs (secreted by blastocysts in the culture medium) and pregnancy outcomes has been well-established. Studies on prediction models for pregnancy outcome, using clinical characteristics and miRNA expression, are limited. We aimed to establish the prediction model for prediction of pregnancy outcome of woman after a fresh cycle of Day 5 single blastocyst transfer (Day 5 SBT) based on clinical data and miRNA expression. A total of 86 women, 50 with successful pregnancy and 36 with pregnancy failure after fresh cycle of Day 5 SBT, were enrolled in this study. All samples were divided into training set and test set (3:1). Based on clinical index statistics of enrolled population and miRNA expression, the prediction model was constructed, followed by validation of the prediction model. Four clinical indicators, female age, sperm DNA fragmentation index, anti-mullerian hormone, estradiol, can be used as independent predictors of pregnancy failure after fresh cycle of Day 5 SBT. Three miRNAs (hsa-miR-199a-3p, hsa-miR-199a-5p and hsa-miR-99a-5p) had a potential diagnostic value for pregnancy failure after Day 5 SBT. The predictive effect of model combining 4 clinical indicators and 3 miRNAs (area under the receiver operating characteristic curve, AUC = 0.853) was better than models combining single 4 clinical indicators (AUC = 0.755) or 3 miRNAs (AUC = 0.713). Based on 4 clinical indicators and 3 miRNAs, a novel model to predict pregnancy outcome in woman after fresh cycle of Day 5 SBT has been developed and validated. The predictive model may be valuable for clinicians to make the optimal clinical decision and patient selection.

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Section: Discussionmentioning

confidence: 91%

A validated model for individualized prediction of pregnancy outcome in woman after fresh cycle of Day 5 single blastocyst transfer

Chen

Jiang

et al. 2023

Sci Rep

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“…In the present study, an AMH cutoff level of 1.12 ng/mL was suggested, with levels above the cutoff value being correlated with successful donation. Baker et al . (2021 ) predicted a cutoff level of 0.93 ng/mL.…”

Section: Discussionmentioning

confidence: 99%

Female Reproductive Health – study of an egg donor population

Oliveira,

Barreiro,

Tomé

et al. 2023

JBRA

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Objective Infertility is one of the most significant reproductive health issues addressed with medically assisted procreation. This study looked into a potential correlation between the number of mature oocytes harvested and donor biological characteristics in order to propose an anti-Müllerian hormone (AMH) cutoff level to optimize the selection of candidates for gamete donation. Methods The donors were healthy women included in the Public Gamete Bank between 2011 and 2021. Their results can be used as a national indicator of fertility. Results We found that women with higher AMH levels had more antral follicles and oocytes harvested. As age increased, the number of oocytes harvested decreased. The suggested AMH cutoff level for successful donation was 1.12 ng/mL. Conclusions The analysis of the reproductive health of Public Gamete Bank donors allows the standardization of AMH cutoff values at a national level, since the same laboratory techniques were employed consistently across medical centers. The study also allowed insight into the factors that compromise donation success. If adopted, a more rigorous selection of donor candidates would increase the success rate of egg donations.

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Ovarian response determines the luteinizing hormone suppression threshold for patients following the gonadotrophin releasing hormone antagonist protocol: A retrospective cohort study

Li,

Zhou,

et al. 2024

Heliyon

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Validation study of the Access antimüllerian hormone assay for the prediction of poor ovarian response to controlled ovarian stimulation

Cited by 8 publications

References 20 publications

A validated model for individualized prediction of pregnancy outcome in woman after fresh cycle of Day 5 single blastocyst transfer

A validated model for individualized prediction of pregnancy outcome in woman after fresh cycle of Day 5 single blastocyst transfer

Female Reproductive Health – study of an egg donor population

Ovarian response determines the luteinizing hormone suppression threshold for patients following the gonadotrophin releasing hormone antagonist protocol: A retrospective cohort study

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