Female Reproductive Health – study of an egg donor population

Abstract

Objective Infertility is one of the most significant reproductive health issues addressed with medically assisted procreation. This study looked into a potential correlation between the number of mature oocytes harvested and donor biological characteristics in order to propose an anti-Müllerian hormone (AMH) cutoff level to optimize the selection of candidates for gamete donation. Methods The donors were healthy women included in the Public Gamete Bank between 2011 and 2021. Their results can be used as a national indicator of fertility. Results We found that women with higher AMH levels had more antral follicles and oocytes harvested. As age increased, the number of oocytes harvested decreased. The suggested AMH cutoff level for successful donation was 1.12 ng/mL. Conclusions The analysis of the reproductive health of Public Gamete Bank donors allows the standardization of AMH cutoff values at a national level, since the same laboratory techniques were employed consistently across medical centers. The study also allowed insight into the factors that compromise donation success. If adopted, a more rigorous selection of donor candidates would increase the success rate of egg donations.

Elevated Anti-Müllerian Hormone as a Prognostic Factor for Poor Outcomes of In Vitro Fertilization in Women with Polycystic Ovary Syndrome

“…The current study lays the groundwork to validate AMH levels as a prognostic factor for pregnancy after IVF in women with PCOS, as AMH levels below 3.7 ng/mL were found to be associated with better pregnancy outcomes. This range of AMH values (under 3.5 ng/mL) is found among healthy women and has been linked with good ovarian response to stimulation [27][28][29]. Although this seems to be transversal to PCOS, the relationship between baseline AMH levels and pregnancy outcomes in women with PCOS may not be as straightforward and requires further investigation.…”