Validation of the Ulcerative Colitis Colonoscopic Index of Severity and Its Correlation With Disease Activity Measures

Correlation between Ulcerative Colitis Endoscopic Index of Severity, Lichtiger Index and Fecal Calprotectin in Ulcerative Colitis Patients

“…The original and modified Baron scores and the Mayo score have been broadly used in the clinical practice and are easy to implement. However, recent studies [14,15,23] have demonstrated that the rate of agreement is only 27% for endoscopic remission [Baron score 0] and 37% for moderate activity [Baron 2]. Inter-observer disagreement has been reported for the severity of inflammation in UC [14].…”

“…Therefore, the development of new methods/ techniques for the assessment of severity is warranted. More recently, the UCEIS and the ulcerative colitis colonoscopic index of severity (UCCIS) were established to address the issue of low inter-observer agreement for endoscopic scores [14,15,23].…”

How Useful Are Blood and Stool Biomarkers for Detecting Subclinical Mucosal Inflammation in Ulcerative Colitis?

“…Recently, the ulcerative colitis endoscopic index of severity (UCEIS) and the ulcerative colitis colonoscopic index of severity (UCCIS), new indices for endoscopic grading of ulcerative colitis, were developed using current principles of index development and digital technology. These indices have also been validated in subsequent studies [9,10], although additional studies are needed to test the validity and usefulness of UCEIS and UCCIS in heterogeneous patient groups. Furthermore, considering the patchy distribution of inflammatory lesions in some patients with UC, total colonic evaluation using UCCIS may reflect more accurate assessment of the inflammatory burden of UC.…”

Endoscopy as a Prognostic Marker in Inflammatory Bowel Disease

“…We herein critically review the data which suggest that endoscopic lesions, their extent and their fate also have a prognostic value in inflammatory bowel disease (IBD). Studies have established elementary lesions observed in subjects with Crohn's disease (CD) and ulcerative colitis (UC), which of them are recognized with a reasonable interobserver agreement and which are associated with overall severity evaluated by experts [2,3,4,5]. At the present time, severity of CD takes into account the extent of lesions in the gastrointestinal tract, while for UC only the most severe lesions are considered and the extent of the disease is not part of the endoscopy severity indices [2,3,4,5].…”

“…Studies have established elementary lesions observed in subjects with Crohn's disease (CD) and ulcerative colitis (UC), which of them are recognized with a reasonable interobserver agreement and which are associated with overall severity evaluated by experts [2,3,4,5]. At the present time, severity of CD takes into account the extent of lesions in the gastrointestinal tract, while for UC only the most severe lesions are considered and the extent of the disease is not part of the endoscopy severity indices [2,3,4,5]. In CD, lesions with an acceptable interobserver agreement include ulcerated and non-ulcerated stenosis, deep ulceration, superficial ulceration, aphthoid ulceration, frankly swollen mucosa, frank erythema, healed ulceration and pseudopolyp [6].…”