Validation of the Sift Technique for Trace Gas Analysis of Breath Using the Syringe Injection Technique

Španěl, Patrik; Cocker, John; Rajan, Bob; Smith, David

doi:10.1093/annhyg/41.3.373

Cited by 16 publications

(1 citation statement)

References 14 publications

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“…range for the Profile 3 SIFT-MS instrument have been validated for aromatic hydrocarbons 32 using analyte ion integration times of 1 min. However, in practice, much shorter integration times are often used, especially when analysing short duration breath exhalations and then a practical limit of quantification (for 30% precision) can be evaluated on the basis of Poisson statistics: 1 ppbv of the neutral compound being analysed is needed to generate 10 recorded analyte ions during 1 s. The absolute accuracy of SIFT-MS has been validated to be better than 10% 33,34 for several compounds without the need for external standards. Similar sensitivities to Profile 3 are also obtained using the Voice 200 c SIFT-MS instruments, 37,38 although much better detection sensitivities have been reported for atmospheric monitoring.…”

Section: The Physics and Ion Chemistry Underpinning The Selected Ion mentioning

confidence: 99%

Account: On the Features, Successes and Challenges of Selected Ion Flow Tube Mass Spectrometry

Španěl

Smith

2013

Eur J Mass Spectrom (Chichester)

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The major features of the selected ion flow tube mass spectrometry (SIFT-MS) analytical method that was conceived and designed for the analysis, in real time, of air obviating sample collections into bags or extraction by pre-concentration of trace compounds onto surfaces are reviewed. The unique analytical capabilities of SIFT-MS for ambient analysis are stressed that allow quantification of volatile organic and inorganic compounds directly from the measurement of physical parameters without the need for regular instrumental calibration using internal or external standards. Then, emphasis is placed on the challenging real-time accurate analysis of single exhalations of humid breath, which is now achieved and readily facilitates wider applications of SIFT-MS in other fields where trace gas analysis has value. The quality of the data obtained by SIFT-MS is illustrated by the quantification of some exhaled breath metabolites that are of immediate relevance to physiology and medicine, including that of hydrogen cyanide in the breath of patients with cystic fibrosis. The current status of SIFT-MS is revealed by a form of a strengths, weakness, opportunities and threats (SWOT) analysis intended to present an objective view of this analytical technique and the likely way forward towards its further development and application.

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